Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0643 | 0.1103 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0643 | 0.1103 | 0.1103 |
Echinococcus multilocularis | acetylcholinesterase | 0.3803 | 0.7088 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0643 | 0.1103 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.3803 | 0.7088 | 0.7088 |
Loa Loa (eye worm) | hypothetical protein | 0.1129 | 0.2024 | 0.2576 |
Brugia malayi | hypothetical protein | 0.0643 | 0.1103 | 0.1103 |
Loa Loa (eye worm) | hypothetical protein | 0.3803 | 0.7088 | 0.9023 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0643 | 0.1103 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0643 | 0.1103 | 0.1404 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.0159 | 0.0202 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0643 | 0.1103 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.3803 | 0.7088 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0643 | 0.1103 | 0.1103 |
Onchocerca volvulus | 0.0643 | 0.1103 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0643 | 0.1103 | 0.1404 |
Onchocerca volvulus | 0.0643 | 0.1103 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0643 | 0.1103 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0643 | 0.1103 | 0.1404 |
Echinococcus granulosus | carboxylesterase 5A | 0.3803 | 0.7088 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0643 | 0.1103 | 0.1404 |
Loa Loa (eye worm) | hypothetical protein | 0.0643 | 0.1103 | 0.1404 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.0159 | 0.0159 |
Onchocerca volvulus | 0.0643 | 0.1103 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0643 | 0.1103 | 0.1404 |
Loa Loa (eye worm) | hypothetical protein | 0.4208 | 0.7856 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0643 | 0.1103 | 0.1404 |
Brugia malayi | Carboxylesterase family protein | 0.0643 | 0.1103 | 0.1103 |
Onchocerca volvulus | 0.0643 | 0.1103 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.3803 | 0.7088 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0643 | 0.1103 | 0.1404 |
Onchocerca volvulus | 0.0643 | 0.1103 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0643 | 0.1103 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.3803 | 0.7088 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.0159 | 0.0202 |
Schistosoma mansoni | alzheimer's disease beta-amyloid related | 0.1947 | 0.3574 | 0.4128 |
Loa Loa (eye worm) | hypothetical protein | 0.0643 | 0.1103 | 0.1404 |
Brugia malayi | Carboxylesterase family protein | 0.0643 | 0.1103 | 0.1103 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3803 | 0.7088 | 0.9023 |
Loa Loa (eye worm) | hypothetical protein | 0.2261 | 0.4168 | 0.5305 |
Brugia malayi | Carboxylesterase family protein | 0.3803 | 0.7088 | 0.7088 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3803 | 0.7088 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3803 | 0.7088 | 0.9023 |
Loa Loa (eye worm) | carboxylesterase | 0.3803 | 0.7088 | 0.9023 |
Echinococcus granulosus | acetylcholinesterase | 0.3803 | 0.7088 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.