Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0047 | 0.0933 | 0.043 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0047 | 0.0933 | 0.0933 |
Echinococcus multilocularis | dna polymerase eta | 0.0077 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.4939 | 0.4418 |
Echinococcus granulosus | dna polymerase kappa | 0.0047 | 0.0933 | 0.0933 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0047 | 0.0933 | 0.0933 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0047 | 0.0933 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0077 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.0933 | 0.043 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0047 | 0.0933 | 0.0933 |
Giardia lamblia | DINP protein human, muc B family | 0.0047 | 0.0933 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0047 | 0.0933 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0077 | 1 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0047 | 0.0933 | 0.0933 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.4939 | 0.4418 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0047 | 0.0933 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0077 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0077 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0047 | 0.0933 | 0.043 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0047 | 0.0933 | 0.0933 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.0933 | 0.043 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.4939 | 0.4939 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0047 | 0.0933 | 0.5 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0045 | 0.0525 | 0.5 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0047 | 0.0933 | 0.0933 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0047 | 0.0933 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.0933 | 0.043 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0047 | 0.0933 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0077 | 1 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0047 | 0.0933 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.4939 | 0.4939 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.0933 | 0.043 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 84.9214 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.