Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | twik family of potassium channels-related | 0.0145 | 0.0288 | 0.0288 |
Echinococcus multilocularis | TWiK family of potassium channels protein 7 | 0.0145 | 0.0288 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Trypanosoma cruzi | ion transport protein, putative | 0.0145 | 0.0288 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0145 | 0.0288 | 1 |
Onchocerca volvulus | Telomerase reverse transcriptase homolog | 0.0303 | 0.0769 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0145 | 0.0288 | 1 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0145 | 0.0288 | 0.0288 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Brugia malayi | Cache domain containing protein | 0.0373 | 0.0982 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0843 | 0.2413 | 0.2404 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Echinococcus multilocularis | twik family of potassium channels | 0.0145 | 0.0288 | 0.0275 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0145 | 0.0288 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0301 | 0.0288 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0145 | 0.0288 | 0.5 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.1853 | 0.5492 | 0.5486 |
Echinococcus multilocularis | twik family of potassium channels | 0.0145 | 0.0288 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0373 | 0.0982 | 0.0971 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0145 | 0.0288 | 0.5 |
Plasmodium falciparum | potassium channel | 0.0145 | 0.0288 | 1 |
Echinococcus multilocularis | potassium channel subfamily K 8 | 0.0145 | 0.0288 | 0.0275 |
Echinococcus granulosus | twik family of potassium channels | 0.0145 | 0.0288 | 0.0275 |
Mycobacterium ulcerans | transmembrane cation transporter | 0.0145 | 0.0288 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0145 | 0.0288 | 0.0288 |
Echinococcus granulosus | TWiK family of potassium channels protein 7 | 0.0145 | 0.0288 | 0.0275 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.0145 | 0.0288 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Schistosoma mansoni | hypothetical protein | 0.3333 | 1 | 1 |
Echinococcus multilocularis | calcium activated potassium channel variant | 0.0145 | 0.0288 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.1493 | 0.4396 | 0.4388 |
Schistosoma mansoni | calcium-activated potassium channel | 0.3333 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Schistosoma mansoni | amine GPCR | 0.0381 | 0.1005 | 0.1005 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.0288 | 0.0288 |
Echinococcus multilocularis | potassium channel subfamily K 8 | 0.0145 | 0.0288 | 0.0275 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0408 | 0.1087 | 0.1087 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0145 | 0.0288 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.134 | 0.3929 | 0.3921 |
Echinococcus granulosus | potassium channel subfamily K | 0.0145 | 0.0288 | 0.0275 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0145 | 0.0288 | 0.5 |
Loa Loa (eye worm) | S-phase kinase-associated protein 1A | 0.0145 | 0.0288 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Trypanosoma brucei | calcium-activated potassium channel, putative | 0.0145 | 0.0288 | 1 |
Loa Loa (eye worm) | TWK-28 protein | 0.0145 | 0.0288 | 0.0275 |
Leishmania major | calcium/potassium channel (CAKC), putative | 0.0145 | 0.0288 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Schistosoma mansoni | calcium-activated potassium channel | 0.2834 | 0.8479 | 0.8479 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Plasmodium vivax | potassium channel, putative | 0.0145 | 0.0288 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.3333 | 1 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.015 | 0.0301 | 0.0288 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Leishmania major | ion transport protein-like protein | 0.0145 | 0.0288 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Plasmodium falciparum | potassium channel | 0.0145 | 0.0288 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Loa Loa (eye worm) | TWK-7 protein | 0.0145 | 0.0288 | 0.0275 |
Trypanosoma cruzi | ion transport protein, putative | 0.0145 | 0.0288 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0145 | 0.0288 | 0.0288 |
Giardia lamblia | Hypothetical protein | 0.0145 | 0.0288 | 1 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0145 | 0.0288 | 0.0288 |
Mycobacterium tuberculosis | Possible transmembrane cation transporter | 0.0145 | 0.0288 | 0.5 |
Toxoplasma gondii | ion channel protein | 0.0145 | 0.0288 | 1 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0145 | 0.0288 | 0.0288 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Toxoplasma gondii | ion channel protein | 0.0145 | 0.0288 | 1 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0145 | 0.0288 | 0.0288 |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.0145 | 0.0288 | 1 |
Schistosoma mansoni | serine-rich repeat protein | 0.0435 | 0.1172 | 0.1172 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.0301 | 0.0288 |
Echinococcus granulosus | calcium activated potassium channel variant | 0.0145 | 0.0288 | 0.0275 |
Plasmodium vivax | potassium channel, putative | 0.0145 | 0.0288 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Loa Loa (eye worm) | potassium voltage-gated channel subfamily Q member 5 | 0.0145 | 0.0288 | 0.0275 |
Entamoeba histolytica | calcium-gated potassium channel protein, putative | 0.0145 | 0.0288 | 0.5 |
Echinococcus multilocularis | potassium channel subfamily K | 0.0145 | 0.0288 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Trypanosoma brucei | calcium/potassium channel (CAKC), putative | 0.0145 | 0.0288 | 1 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0808 | 0.2309 | 0.2309 |
Leishmania major | potassium channel subunit-like protein | 0.0145 | 0.0288 | 1 |
Echinococcus granulosus | potassium channel subfamily K 8 | 0.0145 | 0.0288 | 0.0275 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0145 | 0.0288 | 0.5 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0145 | 0.0288 | 0.0288 |
Trypanosoma cruzi | calcium-activated potassium channel, putative | 0.0145 | 0.0288 | 1 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.1853 | 0.5492 | 0.5486 |
Echinococcus granulosus | Two pore potassium channel protein sup 9 | 0.0145 | 0.0288 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Trypanosoma cruzi | calcium/potassium channel (CAKC), putative | 0.0145 | 0.0288 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Loa Loa (eye worm) | large conductance calcium-activated potassium channel alpha subunit ai | 0.0145 | 0.0288 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Schistosoma mansoni | hypothetical protein | 0.0435 | 0.1172 | 0.1172 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Echinococcus granulosus | twik family of potassium channels | 0.0145 | 0.0288 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0354 | 0.0923 | 0.0912 |
Echinococcus granulosus | potassium channel subfamily K 8 | 0.0145 | 0.0288 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.015 | 0.0301 | 0.0301 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0843 | 0.2413 | 0.2404 |
Mycobacterium ulcerans | ion transport protein | 0.0145 | 0.0288 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0145 | 0.0288 | 0.0288 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Schistosoma mansoni | twik family of potassium channels-related | 0.0145 | 0.0288 | 0.0288 |
Echinococcus multilocularis | serotonin receptor | 0.015 | 0.0301 | 0.0288 |
Brugia malayi | Telomerase reverse transcriptase | 0.022 | 0.0517 | 0.3299 |
Echinococcus multilocularis | serotonin receptor | 0.015 | 0.0301 | 0.0288 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Echinococcus multilocularis | Two pore potassium channel protein sup 9 | 0.0145 | 0.0288 | 0.0275 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0145 | 0.0288 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.3333 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0288 | 0.0275 |
Loa Loa (eye worm) | uncoordinated protein 58 | 0.0145 | 0.0288 | 0.0275 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.