Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0043 | 0.1284 | 0.0764 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0898 | 0.1666 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0142 | 0.5953 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1342 | 0.0845 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0898 | 0.1462 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0898 | 0.1666 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0087 | 0.3358 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0222 | 0.9733 | 0.9707 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0898 | 0.0857 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.1342 | 0.0845 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0898 | 0.1666 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0087 | 0.3358 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0087 | 0.3358 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0898 | 0.0857 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0898 | 0.0857 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1342 | 0.0845 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0898 | 0.0513 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0087 | 0.3358 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0087 | 0.3358 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.1342 | 0.1629 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0146 | 0.6146 | 1 |
Onchocerca volvulus | 0.0035 | 0.0898 | 0.5 | |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0.1116 | 0.5 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0039 | 0.1116 | 0.0739 |
Treponema pallidum | polypeptide deformylase (def) | 0.0228 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0228 | 1 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1342 | 0.0845 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1342 | 0.0877 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0043 | 0.1284 | 1 |
Onchocerca volvulus | 0.0035 | 0.0898 | 0.5 | |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0228 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0407 | 0.0662 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0146 | 0.6146 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0087 | 0.3358 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0043 | 0.1284 | 1 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0228 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.1342 | 0.0877 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.1342 | 0.0845 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0043 | 0.1284 | 0.0915 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0898 | 0.1462 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0043 | 0.1284 | 0.0915 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0898 | 0.1666 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0146 | 0.6146 | 1 |
Onchocerca volvulus | 0.0035 | 0.0898 | 0.5 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.1342 | 0.2183 |
Plasmodium falciparum | peptide deformylase | 0.0228 | 1 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.0228 | 1 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.0146 | 0.6146 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0898 | 0.1462 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0898 | 0.0857 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0898 | 0.0513 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0898 | 0.0857 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0043 | 0.1284 | 0.0915 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0039 | 0.1116 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.0228 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0898 | 0.0857 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0898 | 0.1462 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0898 | 0.0857 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0087 | 0.3358 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0228 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0898 | 0.0857 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.