Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0212 | 0.1918 | 0.3613 |
Plasmodium falciparum | peptidase, putative | 0.0056 | 0.027 | 1 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0056 | 0.027 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0212 | 0.1918 | 0.5 |
Toxoplasma gondii | acylaminoacyl-peptidase, putative | 0.0056 | 0.027 | 0.0508 |
Trypanosoma cruzi | oligopeptidase b | 0.0212 | 0.1918 | 0.3613 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0534 | 0.5308 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.0534 | 0.5308 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0056 | 0.027 | 0.0508 |
Loa Loa (eye worm) | hypothetical protein | 0.0534 | 0.5308 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0534 | 0.5308 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0534 | 0.5308 | 0.5178 |
Toxoplasma gondii | prolyl endopeptidase | 0.0534 | 0.5308 | 1 |
Trypanosoma brucei | Alpha/beta hydrolase domain-containing protein | 0.0056 | 0.027 | 0.0508 |
Toxoplasma gondii | hypothetical protein | 0.0056 | 0.027 | 0.0508 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0056 | 0.027 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0056 | 0.027 | 0.0508 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0056 | 0.027 | 0.0508 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0212 | 0.1918 | 0.3613 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0056 | 0.027 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0056 | 0.027 | 0.0508 |
Trypanosoma cruzi | oligopeptidase b | 0.0212 | 0.1918 | 0.3613 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0056 | 0.027 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0056 | 0.027 | 0.5 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0534 | 0.5308 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0056 | 0.027 | 0.0508 |
Echinococcus granulosus | prolyl endopeptidase | 0.0534 | 0.5308 | 1 |
Trypanosoma brucei | oligopeptidase b | 0.0212 | 0.1918 | 0.3613 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0056 | 0.027 | 0.0508 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0056 | 0.027 | 0.5 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0212 | 0.1918 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0056 | 0.027 | 0.0508 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0056 | 0.027 | 0.0508 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0534 | 0.5308 | 1 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0212 | 0.1918 | 0.3613 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0534 | 0.5308 | 1 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0056 | 0.027 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0056 | 0.027 | 0.0508 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.027 | 0.0508 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0056 | 0.027 | 0.0508 |
Leishmania major | oligopeptidase b | 0.0212 | 0.1918 | 0.3613 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0056 | 0.027 | 0.0508 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0056 | 0.027 | 0.0508 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.027 | 0.0508 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0056 | 0.027 | 0.0508 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0056 | 0.027 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0478 | 0.4718 | 1 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0212 | 0.1918 | 0.3613 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0056 | 0.027 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0056 | 0.027 | 1 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0212 | 0.1918 | 0.3613 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0056 | 0.027 | 0.0508 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0056 | 0.027 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0056 | 0.027 | 0.5 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0534 | 0.5308 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0019 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3489 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 84.9214 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.