TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 484.609 | Formula: C29H28N2O3S
H donors: 1 H acceptors: 3 LogP: 3.14 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OS(=O)(=O)c1ccc2c(c1)cccc2.CN1CCc2c(C1)c1ccccc1n2Cc1ccccc1
InChi: 1S/C19H20N2.C10H8O3S/c1-20-12-11-19-17(14-20)16-9-5-6-10-18(16)21(19)13-15-7-3-2-4-8-15;11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10/h2-10H,11-14H2,1H3;1-7H,(H,11,12,13)
InChiKey: YCDAPCCNEGKIRH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	parathyroid hormone 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	isocitrate dehydrogenase 1 (NADP+), soluble	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei gambiense	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium berghei	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	hypothetical protein	Get druggable targets OG5_127057	All targets in OG5_127057
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	ko:K04588 secretin receptor, putative	Get druggable targets OG5_139196	All targets in OG5_139196
Babesia bovis	isocitrate dehydrogenase, NADP-dependent family protein	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	Isocitrate dehydrogenase-like protein, related	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania mexicana	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania donovani	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania braziliensis	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	Isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	C terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Theileria parva	isocitrate dehydrogenase (NADP+), putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium knowlesi	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania infantum	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	N terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0024	0.0507	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0183	0.0183
Toxoplasma gondii	aminopeptidase N protein	0.0019	0.028	0.2999
Loa Loa (eye worm)	hypothetical protein	0.0019	0.028	0.028
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0036	0.101	0.4889
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0055	0.1874	0.219
Brugia malayi	Latrophilin receptor protein 2	0.0038	0.1118	0.1118
Echinococcus granulosus	glycoprotein Antigen 5	0.0016	0.0118	0.0138
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0019	0.0268	0.0314
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0019	0.028	0.0328
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0019	0.028	0.0573
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0066	0.2374	0.2374
Toxoplasma gondii	isocitrate dehydrogenase	0.0019	0.0268	0.2628
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0036	0.101	0.118
Schistosoma mansoni	cercarial elastase (S01 family)	0.0016	0.0118	0.0138
Trypanosoma brucei	Aminopeptidase M1, putative	0.0055	0.1874	1
Schistosoma mansoni	hypothetical protein	0.0038	0.1118	0.1306
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0118	0.0118
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0055	0.1874	0.219
Loa Loa (eye worm)	hypothetical protein	0.0019	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0118	0.0118
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0178	0.739	0.8635
Echinococcus granulosus	aminopeptidase N	0.0121	0.4821	0.5634
Toxoplasma gondii	kringle domain-containing protein	0.0024	0.0507	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0016	0.0118	0.0138
Trypanosoma brucei	Aminopeptidase M1, putative	0.0055	0.1874	1
Brugia malayi	Trypsin family protein	0.0016	0.0118	0.0118
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0019	0.0268	0.0314
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0019	0.028	0.0573
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0055	0.1874	1
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0019	0.028	0.0328
Schistosoma mansoni	integrin beta subunit	0.014	0.5648	0.66
Schistosoma mansoni	cercarial elastase (S01 family)	0.0016	0.0118	0.0138
Schistosoma mansoni	cercarial elastase (S01 family)	0.0016	0.0118	0.0138
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0071	0.2577	0.3011
Echinococcus granulosus	enteropeptidase	0.0016	0.0118	0.0138
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0019	0.028	0.0328
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0019	0.028	0.2999
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0055	0.1874	0.219
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1118	0.1118
Schistosoma mansoni	cercarial elastase (S01 family)	0.0016	0.0118	0.0138
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0019	0.028	0.0328
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0019	0.028	0.0573
Echinococcus multilocularis	GPCR, family 2	0.0038	0.1118	0.1306
Echinococcus granulosus	GPCR family 2	0.0038	0.1118	0.1306
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0268	0.0314
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0019	0.028	0.0328
Echinococcus multilocularis	Mastin	0.0016	0.0118	0.0138
Loa Loa (eye worm)	TK/ROR protein kinase	0.0024	0.0507	0.0507
Entamoeba histolytica	aminopeptidase, putative	0.0055	0.1874	1
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0017	0.0183	0.0214
Brugia malayi	hypothetical protein	0.0016	0.0118	0.0118
Schistosoma mansoni	hypothetical protein	0.0038	0.1118	0.1306
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0055	0.1874	1
Brugia malayi	Trypsin family protein	0.0016	0.0118	0.0118
Onchocerca volvulus		0.0016	0.0118	0.016
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0016	0.0118	0.0138
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0019	0.028	0.2999
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0118	0.0118
Schistosoma mansoni	cercarial elastase (S01 family)	0.0016	0.0118	0.0138
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0019	0.028	0.028
Echinococcus multilocularis	isocitrate dehydrogenase	0.0019	0.0268	0.0314
Brugia malayi	Trypsin family protein	0.0016	0.0118	0.0118
Trypanosoma cruzi	hypothetical protein, conserved	0.0024	0.0507	0.1912
Echinococcus granulosus	integrin beta 2	0.0176	0.7257	0.848
Brugia malayi	Protein kinase domain containing protein	0.0024	0.0507	0.0507
Onchocerca volvulus		0.0016	0.0118	0.016
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0036	0.1024	0.1024
Schistosoma mansoni	cercarial elastase (S01 family)	0.0016	0.0118	0.0138
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0055	0.1874	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0118	0.0138
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0019	0.0268	0.2628
Schistosoma mansoni	growth factor receptor-bound protein	0.0066	0.2374	0.2774
Plasmodium falciparum	cysteine repeat modular protein 1	0.0024	0.0507	1
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0019	0.0268	0.0503
Onchocerca volvulus		0.0163	0.6688	0.905
Brugia malayi	Kringle domain containing protein	0.0024	0.0507	0.0507
Schistosoma mansoni	hypothetical protein	0.0082	0.3093	0.3614
Echinococcus multilocularis	integrin beta 2	0.0176	0.7257	0.848
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0268	0.0503
Onchocerca volvulus		0.0016	0.0118	0.016
Echinococcus granulosus	Mastin	0.0016	0.0118	0.0138
Onchocerca volvulus		0.0024	0.0507	0.0686
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0055	0.1874	0.219
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0016	0.0118	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0036	0.101	0.101
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0268	0.0503
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0019	0.0268	1
Mycobacterium ulcerans	aminopeptidase N PepN	0.0055	0.1874	1
Loa Loa (eye worm)	TATA binding protein associated factor	0.0019	0.028	0.028
Mycobacterium ulcerans	aminopeptidase N PepN	0.0019	0.028	0.0924
Toxoplasma gondii	aminopeptidase N, putative	0.0019	0.028	0.2999
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0019	0.0268	0.2628
Schistosoma mansoni	hypothetical protein	0.0016	0.0118	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3093	0.3093
Brugia malayi	Kelch motif family protein	0.0036	0.1024	0.1024
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1024	0.1024
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0055	0.1874	1
Onchocerca volvulus		0.0016	0.0118	0.016
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0118	0.0118
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0019	0.028	0.0573
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0019	0.0268	0.0503
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0017	0.0183	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0178	0.739	0.739
Brugia malayi	TATA binding protein associated factor	0.0019	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0019	0.028	0.028
Brugia malayi	latrophilin 2 splice variant baaae	0.0082	0.3093	0.3093
Brugia malayi	Trypsin family protein	0.0178	0.739	0.739
Toxoplasma gondii	aminopeptidase n, putative	0.0019	0.028	0.2999
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0016	0.0118	0.0138
Onchocerca volvulus		0.0121	0.4821	0.6524
Echinococcus multilocularis	glycoprotein Antigen 5	0.0016	0.0118	0.0138
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0017	0.0183	0.0214
Echinococcus granulosus	tissue type plasminogen activator	0.0024	0.0507	0.0592
Loa Loa (eye worm)	hypothetical protein	0.012	0.4795	0.4795
Brugia malayi	hypothetical protein	0.0036	0.1024	0.1024
Trypanosoma cruzi	aminopeptidase, putative	0.0055	0.1874	1
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0019	0.028	0.2999
Echinococcus granulosus	transmembrane protease serine 3	0.0016	0.0118	0.0138
Brugia malayi	Trypsin-like protease protein 5	0.0016	0.0118	0.0118
Brugia malayi	hypothetical protein	0.0019	0.028	0.028
Schistosoma mansoni	cercarial elastase (S01 family)	0.0016	0.0118	0.0138
Trypanosoma brucei	aminopeptidase, putative	0.0019	0.028	0.0573
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0016	0.0118	0.0138
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0085	0.3227	0.3227
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0055	0.1874	1
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.0017	0.0183	0.5
Treponema pallidum	ATP-dependent RNA helicase	0.0017	0.0183	0.5
Schistosoma mansoni	cercarial elastase (S01 family)	0.0016	0.0118	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0118	0.0118
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0024	0.0507	1
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0019	0.0268	0.0268
Onchocerca volvulus		0.0178	0.739	1
Brugia malayi	Isocitrate dehydrogenase	0.0019	0.0268	0.0268
Onchocerca volvulus		0.0019	0.028	0.0379
Echinococcus multilocularis	aminopeptidase N	0.0121	0.4821	0.5634
Schistosoma mansoni	cercarial elastase (S01 family)	0.0016	0.0118	0.0138
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0055	0.1874	0.219
Echinococcus multilocularis	geminin	0.0205	0.8558	1
Echinococcus multilocularis	transmembrane protease serine 3	0.0016	0.0118	0.0138
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0016	0.0118	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0178	0.739	0.739
Schistosoma mansoni	hypothetical protein	0.0205	0.8558	1
Brugia malayi	isocitrate dehydrogenase	0.0019	0.0268	0.0268
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0017	0.0183	0.0248
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0016	0.0118	0.0138
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0066	0.2374	0.2774
Echinococcus multilocularis	enteropeptidase	0.0016	0.0118	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0036	0.101	0.101
Loa Loa (eye worm)	aminopeptidase N	0.0055	0.1874	0.1874
Brugia malayi	eukaryotic initiation factor 4A	0.0017	0.0183	0.0183
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0055	0.1874	1
Schistosoma mansoni	hypothetical protein	0.0205	0.8558	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3957	0.3957
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0507	0.0507
Echinococcus granulosus	growth factor receptor bound protein 2	0.0066	0.2374	0.2774
Leishmania major	hypothetical protein, conserved	0.0024	0.0507	0.1912
Loa Loa (eye worm)	hypothetical protein	0.0066	0.2363	0.2363
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0055	0.1874	0.219
Echinococcus granulosus	geminin	0.0205	0.8558	1
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0019	0.0268	0.0314
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0055	0.1874	0.219
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0016	0.0118	0.0138
Brugia malayi	Peptidase family M1 containing protein	0.0055	0.1874	0.1874
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0038	0.1118	0.1118
Loa Loa (eye worm)	trypsin family protein	0.0016	0.0118	0.0118
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0016	0.0118	0.0138
Echinococcus multilocularis	tissue type plasminogen activator	0.0024	0.0507	0.0592
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0019	0.028	0.0573
Schistosoma mansoni	family M1 non-peptidase homologue (M01 family)	0.0036	0.101	0.118
Brugia malayi	Sex muscle abnormal protein 5	0.0066	0.2374	0.2374
Brugia malayi	Peptidase family M1 containing protein	0.0019	0.028	0.028
Onchocerca volvulus		0.0016	0.0118	0.016
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0019	0.028	0.0573
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0019	0.028	0.0328
Schistosoma mansoni	growth factor receptor-bound protein	0.0066	0.2374	0.2774
Trypanosoma cruzi	aminopeptidase, putative	0.0019	0.028	0.0573
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0017	0.0183	0.0214
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0038	0.1118	0.1306
Schistosoma mansoni	hypothetical protein	0.0038	0.1118	0.1306
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0016	0.0118	0.0138
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0019	0.028	0.0573
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0038	0.1118	0.1118
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0019	0.028	0.2999
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0055	0.1874	0.219
Onchocerca volvulus		0.0055	0.1874	0.2537
Schistosoma mansoni	hypothetical protein	0.0038	0.1118	0.1306
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.018	0.7457	0.8713
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0268	0.0314
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.0268	0.0503
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0016	0.0118	0.0118
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0019	0.028	0.0328
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0017	0.0183	0.0214
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0017	0.0183	0.0214
Loa Loa (eye worm)	integrin beta-2	0.0237	1	1
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0055	0.1874	0.219
Brugia malayi	Calcitonin receptor-like protein seb-1	0.012	0.4795	0.4795
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0055	0.1874	0.219
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0268	0.0314
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.012	0.4795	0.4795
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0055	0.1874	0.219
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0038	0.1118	0.1306
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0038	0.1118	0.1306
Schistosoma mansoni	cercarial elastase (S01 family)	0.0016	0.0118	0.0138
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0055	0.1874	1
Brugia malayi	Peptidase family M1 containing protein	0.0121	0.4821	0.4821
Toxoplasma gondii	isocitrate dehydrogenase	0.0019	0.0268	0.2628
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0038	0.1118	0.1306
Brugia malayi	hypothetical protein	0.0055	0.1874	0.1874
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.012	0.4795	0.4795

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.1032 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1714118

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1484408