Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable peptidase | 0.1071 | 0.1112 | 0.5 |
Brugia malayi | hypothetical protein | 0.3472 | 0.43 | 0.43 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.7325 | 0.9416 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.1071 | 0.1112 | 0.5 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.1071 | 0.1112 | 0.1181 |
Brugia malayi | prolyl oligopeptidase family protein | 0.1071 | 0.1112 | 0.1112 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.1071 | 0.1112 | 0.1112 |
Trypanosoma brucei | Alpha/beta hydrolase domain-containing protein | 0.1071 | 0.1112 | 0.1181 |
Entamoeba histolytica | hypothetical protein, conserved | 0.1071 | 0.1112 | 0.5 |
Trypanosoma cruzi | prolyl endopeptidase | 0.1071 | 0.1112 | 0.1181 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.1071 | 0.1112 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.1071 | 0.1112 | 0.1112 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.7325 | 0.9416 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.1071 | 0.1112 | 0.5 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.1071 | 0.1112 | 0.1181 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.7325 | 0.9416 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1071 | 0.1112 | 0.1112 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.1071 | 0.1112 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.7325 | 0.9416 | 1 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.1071 | 0.1112 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3472 | 0.43 | 0.43 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1071 | 0.1112 | 0.1181 |
Trypanosoma brucei | oligopeptidase b | 0.1071 | 0.1112 | 0.1181 |
Loa Loa (eye worm) | hypothetical protein | 0.1071 | 0.1112 | 0.1112 |
Loa Loa (eye worm) | hypothetical protein | 0.3853 | 0.4806 | 0.4806 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.7325 | 0.9416 | 0.9343 |
Brugia malayi | prolyl oligopeptidase family protein | 0.1071 | 0.1112 | 0.1112 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.7325 | 0.9416 | 0.9343 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.4543 | 0.5722 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.7764 | 1 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.7325 | 0.9416 | 0.9343 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1071 | 0.1112 | 0.1181 |
Brugia malayi | prolyl oligopeptidase family protein | 0.7325 | 0.9416 | 0.9416 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.7764 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1071 | 0.1112 | 0.5 |
Trypanosoma brucei | prolyl endopeptidase | 0.1071 | 0.1112 | 0.1181 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.1071 | 0.1112 | 0.5 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.1071 | 0.1112 | 0.5 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.1071 | 0.1112 | 0.1181 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.1071 | 0.1112 | 0.1181 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.7764 | 1 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.1071 | 0.1112 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.1071 | 0.1112 | 0.5 |
Trypanosoma cruzi | oligopeptidase b | 0.1071 | 0.1112 | 0.1181 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.1071 | 0.1112 | 0.5 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.1071 | 0.1112 | 0.1181 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.7764 | 1 | 1 |
Plasmodium falciparum | peptidase, putative | 0.1071 | 0.1112 | 0.5 |
Leishmania major | oligopeptidase b | 0.1071 | 0.1112 | 0.1181 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.1071 | 0.1112 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.7325 | 0.9416 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.1071 | 0.1112 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.1071 | 0.1112 | 0.5 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.1071 | 0.1112 | 0.1181 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.7764 | 1 | 1 |
Trypanosoma cruzi | oligopeptidase b | 0.1071 | 0.1112 | 0.1181 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.