Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | programmed cell death protein 6 | 0.005 | 0 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.3429 | 1 | 1 |
Echinococcus granulosus | Calcium binding protein | 0.005 | 0 | 0.5 |
Echinococcus granulosus | calcyphosin protein | 0.005 | 0 | 0.5 |
Trypanosoma brucei | ferric reductase transmembrane protein, putative | 0.2147 | 0.6206 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1282 | 0.3646 | 0.3646 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.2147 | 0.6206 | 0.5 |
Trichomonas vaginalis | calcium binding protein, putative | 0.005 | 0 | 0.5 |
Giardia lamblia | Programmed cell death protein-like protein | 0.005 | 0 | 0.5 |
Plasmodium falciparum | centrin-4 | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | Calcium binding protein | 0.005 | 0 | 0.5 |
Toxoplasma gondii | calmodulin, putative | 0.005 | 0 | 0.5 |
Treponema pallidum | hypothetical protein | 0.0613 | 0.1667 | 0.5 |
Toxoplasma gondii | calcium binding protein precursor, putative | 0.005 | 0 | 0.5 |
Echinococcus granulosus | programmed cell death protein 6 | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | calcyphosin protein | 0.005 | 0 | 0.5 |
Trichomonas vaginalis | caltractin, putative | 0.005 | 0 | 0.5 |
Trichomonas vaginalis | caltractin, putative | 0.005 | 0 | 0.5 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.2147 | 0.6206 | 0.5 |
Leishmania major | ferric reductase, putative | 0.2147 | 0.6206 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.3429 | 1 | 1 |
Toxoplasma gondii | EF hand domain-containing protein | 0.005 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0613 | 0.1667 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 2 ug ml-1 | Antifungal activity against aspergillus fumigatus | ChEMBL. | 7629803 |
MIC (functional) | = 16 ug ml-1 | Antifungal activity against candida albicans | ChEMBL. | 7629803 |
MIC (functional) | = 16 ug ml-1 | Antifungal activity against candida albicans | ChEMBL. | 7629803 |
MIC (functional) | = 31 ug ml-1 | Antifungal activity against cryptococcus neoformans | ChEMBL. | 7629803 |
MIC (functional) | = 31 ug ml-1 | Antifungal activity against cryptococcus neoformans | ChEMBL. | 7629803 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.