Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0093 | 0.1788 | 0.1788 |
Leishmania major | cathepsin L-like protease | 0.0136 | 0.562 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0084 | 0.1023 | 0.1115 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0136 | 0.562 | 0.562 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0093 | 0.1788 | 0.1788 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0084 | 0.1023 | 0.1115 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0084 | 0.1023 | 1 |
Leishmania major | cathepsin L-like protease | 0.0136 | 0.562 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0093 | 0.1788 | 0.1788 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0136 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0136 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0084 | 0.1023 | 0.1023 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0136 | 0.562 | 0.562 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0136 | 0.562 | 0.562 |
Leishmania major | cysteine peptidase A (CPA) | 0.0136 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0136 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0136 | 0.562 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0136 | 0.562 | 0.562 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0136 | 0.562 | 0.5415 |
Onchocerca volvulus | Cathepsin F homolog | 0.0136 | 0.562 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0186 | 1 | 1 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0084 | 0.1023 | 0.1821 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0136 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0136 | 0.562 | 0.562 |
Loa Loa (eye worm) | fibroinase | 0.0136 | 0.562 | 0.5415 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1023 | 0.0604 |
Onchocerca volvulus | 0.0136 | 0.562 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0093 | 0.1788 | 0.1788 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0136 | 0.562 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0136 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0093 | 0.1788 | 0.3182 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0084 | 0.1023 | 0.1023 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0186 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0136 | 0.562 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0136 | 0.562 | 0.5415 |
Echinococcus multilocularis | cathepsin b | 0.0186 | 1 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0084 | 0.1023 | 0.1115 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0186 | 1 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0136 | 0.562 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0186 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0136 | 0.562 | 0.5415 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0084 | 0.1023 | 0.1821 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0077 | 0.0446 | 0.0446 |
Loa Loa (eye worm) | ctsf protein | 0.0136 | 0.562 | 0.5415 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0093 | 0.1788 | 0.3182 |
Echinococcus granulosus | cathepsin b | 0.0186 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0136 | 0.562 | 0.562 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1788 | 0.1405 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Plasmodium vivax | vivapain-2 | 0.0136 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0136 | 0.562 | 0.562 |
Leishmania major | cathepsin L-like protease | 0.0136 | 0.562 | 1 |
Onchocerca volvulus | 0.0136 | 0.562 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0136 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Onchocerca volvulus | 0.0136 | 0.562 | 1 | |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0084 | 0.1023 | 0.1023 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0077 | 0.0446 | 0.0446 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1788 | 0.1405 |
Leishmania major | cathepsin L-like protease | 0.0136 | 0.562 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0136 | 0.562 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.1788 | 0.1405 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0136 | 0.562 | 1 |
Onchocerca volvulus | 0.0136 | 0.562 | 1 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0136 | 0.562 | 0.562 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Plasmodium vivax | vivapain-2 | 0.0136 | 0.562 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0136 | 0.562 | 0.562 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0136 | 0.562 | 0.562 |
Onchocerca volvulus | Cathepsin L homolog | 0.0136 | 0.562 | 1 |
Onchocerca volvulus | 0.0136 | 0.562 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0136 | 0.562 | 0.562 |
Brugia malayi | Cathepsin L-like precursor | 0.0136 | 0.562 | 0.562 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0084 | 0.1023 | 0.1023 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0084 | 0.1023 | 0.1023 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0084 | 0.1023 | 0.1023 |
Brugia malayi | Cathepsin L-like precursor | 0.0136 | 0.562 | 0.562 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0136 | 0.562 | 0.562 |
Brugia malayi | Cathepsin L-like precursor | 0.0136 | 0.562 | 0.562 |
Entamoeba histolytica | cysteine protease, putative | 0.0136 | 0.562 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0084 | 0.1023 | 0.1023 |
Leishmania major | cathepsin L-like protease | 0.0136 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0084 | 0.1023 | 0.1821 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0084 | 0.1023 | 0.5 |
Onchocerca volvulus | 0.0136 | 0.562 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0093 | 0.1788 | 0.1788 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0093 | 0.1788 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.0136 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.0136 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0136 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Leishmania major | cathepsin L-like protease | 0.0136 | 0.562 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0084 | 0.1023 | 0.1821 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0093 | 0.1788 | 0.1788 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0136 | 0.562 | 0.562 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0084 | 0.1023 | 0.1023 |
Brugia malayi | Cathepsin L-like precursor | 0.0136 | 0.562 | 0.562 |
Onchocerca volvulus | 0.0136 | 0.562 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0136 | 0.562 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0093 | 0.1788 | 0.1788 |
Plasmodium vivax | RNA helicase-1, putative | 0.0084 | 0.1023 | 0.1821 |
Echinococcus granulosus | cathepsin b | 0.0186 | 1 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0084 | 0.1023 | 0.1821 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0186 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0136 | 0.562 | 0.562 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0186 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0077 | 0.0446 | 0.0794 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0136 | 0.562 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0136 | 0.562 | 0.562 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0084 | 0.1023 | 0.1023 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0136 | 0.562 | 0.562 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0136 | 0.562 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0136 | 0.562 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0136 | 0.562 | 1 |
Onchocerca volvulus | 0.0093 | 0.1788 | 0.1664 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0136 | 0.562 | 1 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0084 | 0.1023 | 0.5 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0077 | 0.0446 | 0.0794 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0136 | 0.562 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.562 | 0.5415 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0084 | 0.1023 | 0.1821 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0136 | 0.562 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0136 | 0.562 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD50 (ADMET) | = 10 uM | Cytotoxicity against human BJ cells after 72 hrs by Cell titer-glo assay | ChEMBL. | 21243104 |
LD50 (ADMET) | = 10 uM | Cytotoxicity against human HEK293 cells after 72 hrs by Cell titer-glo assay | ChEMBL. | 21243104 |
LD50 (ADMET) | = 10 uM | Cytotoxicity against human HepG2 cells after 72 hrs by Cell titer-glo assay | ChEMBL. | 21243104 |
LD50 (ADMET) | = 10 uM | Cytotoxicity against human Raji cells after 72 hrs by Cell titer-glo assay | ChEMBL. | 21243104 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.