Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable Rieske iron-sulfur protein QcrA (Ubiquinol-cytochrome C reductase iron-sulfur subunit) | 0.0045 | 0.0106 | 0.5 |
Brugia malayi | ubiquinol-cytochrome c reductase, iron-sulfur subunit family protein | 0.0609 | 0.6077 | 1 |
Mycobacterium tuberculosis | Unknown protein | 0.0045 | 0.0106 | 0.5 |
Loa Loa (eye worm) | ubiquinol-cytochrome c reductase | 0.0609 | 0.6077 | 1 |
Mycobacterium ulcerans | ring-hydroxylating dioxygenase, large terminal subunit | 0.0045 | 0.0106 | 0.5 |
Mycobacterium ulcerans | Rieske iron-sulfur protein QcrA | 0.0045 | 0.0106 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0106 | 0.0174 |
Plasmodium falciparum | ferrodoxin reductase-like protein | 0.0045 | 0.0106 | 0.0408 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0078 | 0.0129 |
Brugia malayi | jmjC domain containing protein | 0.0043 | 0.0078 | 0.0129 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0266 | 0.0438 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.0146 | 0.0146 |
Echinococcus granulosus | ubiquinol cytochrome c reductase Rieske | 0.0609 | 0.6077 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0043 | 0.0078 | 0.0129 |
Mycobacterium tuberculosis | Probable rieske iron-sulfur protein QcrA | 0.0045 | 0.0106 | 0.5 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.0146 | 0.024 |
Wolbachia endosymbiont of Brugia malayi | Rieske Fe-S protein | 0.0281 | 0.2599 | 0.5 |
Onchocerca volvulus | Alhambra homolog | 0.0035 | 0 | 0.5 |
Giardia lamblia | PHD finger protein 15 | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.0597 | 0.0983 |
Plasmodium vivax | ferrodoxin reductase, putative | 0.0045 | 0.0106 | 0.0408 |
Trypanosoma cruzi | rieske iron-sulfur protein, mitochondrial precursor, putative | 0.0281 | 0.2599 | 1 |
Leishmania major | reiske iron-sulfur protein precursor, putative | 0.0281 | 0.2599 | 1 |
Trypanosoma brucei | rieske iron-sulfur protein, mitochondrial precursor | 0.0281 | 0.2599 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0115 | 0.0849 | 0.0849 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0078 | 0.0129 |
Mycobacterium ulcerans | dioxygenase | 0.0045 | 0.0106 | 0.5 |
Plasmodium vivax | ubiquinol cytochrome c oxidoreductase, putative | 0.0281 | 0.2599 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0609 | 0.6077 | 1 |
Brugia malayi | ubiquinol-cytochrome c reductase, iron-sulfur subunit family protein | 0.0609 | 0.6077 | 1 |
Echinococcus multilocularis | ubiquinol cytochrome c reductase, Rieske | 0.0609 | 0.6077 | 0.6077 |
Toxoplasma gondii | rieske [2fe-2s] domain-containing protein | 0.0045 | 0.0106 | 0.0408 |
Trypanosoma cruzi | rieske iron-sulfur protein, mitochondrial precursor, putative | 0.0281 | 0.2599 | 1 |
Mycobacterium tuberculosis | Possible dioxygenase | 0.0045 | 0.0106 | 0.5 |
Toxoplasma gondii | pyridine nucleotide-disulfide oxidoreductase domain-containing protein | 0.0045 | 0.0106 | 0.0408 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0115 | 0.0849 | 0.1396 |
Mycobacterium ulcerans | hypothetical protein | 0.0045 | 0.0106 | 0.5 |
Schistosoma mansoni | ubiquinol--cytochrome C reductase | 0.0609 | 0.6077 | 1 |
Plasmodium falciparum | cytochrome b-c1 complex subunit Rieske, putative | 0.0281 | 0.2599 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0045 | 0.0106 | 0.5 |
Toxoplasma gondii | ubiquinol cytochrome c oxidoreductase, putative | 0.0281 | 0.2599 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0045 | 0.0106 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0043 | 0.0078 | 0.0129 |
Brugia malayi | jmjC domain containing protein | 0.0115 | 0.0849 | 0.1396 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.0397 | 0.0653 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.0078 | 0.0078 |
Mycobacterium ulcerans | oxidoreductase | 0.0045 | 0.0106 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.1577 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.