Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0075 | 0.0927 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.019 | 0.3323 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.01 | 0.1448 | 0.3552 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.009 | 0.1236 | 0.3407 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.019 | 0.3323 | 1 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.0114 | 0.1743 | 0.4365 |
Brugia malayi | MH2 domain containing protein | 0.0075 | 0.0927 | 0.5 |
Mycobacterium ulcerans | 3-dehydroquinate synthase | 0.0213 | 0.379 | 1 |
Mycobacterium leprae | 3-dehydroquinate synthase AroB | 0.0213 | 0.379 | 1 |
Mycobacterium tuberculosis | 3-phosphoshikimate 1-carboxyvinyltransferase AroA (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) | 0.0114 | 0.1743 | 0.4365 |
Schistosoma mansoni | 3-dehydroquinate synthase | 0.0213 | 0.379 | 1 |
Mycobacterium tuberculosis | 3-dehydroquinate synthase AroB | 0.0213 | 0.379 | 1 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0213 | 0.379 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.019 | 0.3323 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.009 | 0.1236 | 0.3643 |
Chlamydia trachomatis | dehyroquinate synthase | 0.0213 | 0.379 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0038 | 0.0158 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0075 | 0.0927 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.01 | 0.1448 | 0.3552 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.019 | 0.3323 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0038 | 0.0158 | 0.0416 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.