Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | fructose-1,6-bisphosphatase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | fructose-bisphospatase I | fructose-1,6-bisphosphatase 1 | 338 aa | 326 aa | 31.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | SET domain protein, putative | 0.0035 | 0 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.011 | 0.3121 | 0.3369 |
Schistosoma mansoni | serine/threonine protein kinase | 0.011 | 0.3121 | 0.4894 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.3121 | 0.2509 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0189 | 0.6377 | 1 |
Leishmania major | 0.0189 | 0.6377 | 1 | |
Toxoplasma gondii | fructose-bisphospatase I | 0.007 | 0.1466 | 0.2299 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.011 | 0.3121 | 0.5 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0189 | 0.6377 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0189 | 0.6377 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.011 | 0.3121 | 0.3369 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.3121 | 0.2509 |
Giardia lamblia | Kinase, PLK | 0.011 | 0.3121 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.3121 | 0.2509 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.3121 | 0.2509 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.3121 | 0.2509 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0189 | 0.6377 | 0.7406 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.011 | 0.3121 | 0.3121 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.011 | 0.3121 | 0.3624 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.011 | 0.3121 | 0.3624 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.3121 | 0.2509 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.011 | 0.3121 | 0.3369 |
Brugia malayi | Pre-SET motif family protein | 0.0243 | 0.8611 | 1 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.007 | 0.1466 | 0.2299 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.011 | 0.3121 | 0.4894 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0189 | 0.6377 | 0.7406 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0189 | 0.6377 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.011 | 0.3121 | 0.2509 |
Trichomonas vaginalis | set domain proteins, putative | 0.0277 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.011 | 0.3121 | 0.4894 |
Schistosoma mansoni | kinase | 0.0056 | 0.0877 | 0.1375 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0189 | 0.6377 | 1 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0189 | 0.6377 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0189 | 0.6377 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0243 | 0.8611 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.05 uM | Inhibition of human liver FBP | ChEMBL. | 21126019 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.