Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor alpha 2A | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | AT19640p | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | 390 aa | 335 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ubiquinol-cytochrome c reductase, iron-sulfur subunit family protein | 0.0513 | 0.3502 | 0.6542 |
Loa Loa (eye worm) | hypothetical protein | 0.0383 | 0.1858 | 0.2559 |
Toxoplasma gondii | ubiquinol cytochrome c oxidoreductase, putative | 0.0236 | 0 | 0.5 |
Trypanosoma cruzi | rieske iron-sulfur protein, mitochondrial precursor, putative | 0.0236 | 0 | 0.5 |
Echinococcus multilocularis | ubiquinol cytochrome c reductase, Rieske | 0.0513 | 0.3502 | 0.0594 |
Loa Loa (eye worm) | ubiquinol-cytochrome c reductase | 0.0513 | 0.3502 | 1 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0833 | 0.7562 | 0.6471 |
Plasmodium falciparum | cytochrome b-c1 complex subunit Rieske, putative | 0.0236 | 0 | 0.5 |
Plasmodium vivax | ubiquinol cytochrome c oxidoreductase, putative | 0.0236 | 0 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1026 | 1 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.048 | 0.3091 | 0.7504 |
Echinococcus granulosus | ubiquinol cytochrome c reductase Rieske | 0.0513 | 0.3502 | 0.0594 |
Echinococcus granulosus | hypothetical protein | 0.0859 | 0.7889 | 0.6944 |
Wolbachia endosymbiont of Brugia malayi | Rieske Fe-S protein | 0.0236 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0513 | 0.3502 | 1 |
Brugia malayi | Serotonin receptor | 0.0581 | 0.4371 | 1 |
Trypanosoma cruzi | rieske iron-sulfur protein, mitochondrial precursor, putative | 0.0236 | 0 | 0.5 |
Leishmania major | reiske iron-sulfur protein precursor, putative | 0.0236 | 0 | 0.5 |
Brugia malayi | ubiquinol-cytochrome c reductase, iron-sulfur subunit family protein | 0.0513 | 0.3502 | 0.6542 |
Loa Loa (eye worm) | hypothetical protein | 0.0383 | 0.1858 | 0.2559 |
Schistosoma mansoni | ubiquinol--cytochrome C reductase | 0.0513 | 0.3502 | 1 |
Trypanosoma brucei | rieske iron-sulfur protein, mitochondrial precursor | 0.0236 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Agonist activity at 5-HT2B receptor at 0.1 nM to 10 uM by FLIPR assay | ChEMBL. | 21093272 | |
IC50 (functional) | = 8.2 nM | Antagonist activity at cloned human 5-HT6 receptor expressed in human HeLa cells assessed as inhibition of 5HT-induced cyclic AMP formation | ChEMBL. | 21093272 |
Imax (functional) | = 100 % | Antagonist activity at cloned human 5-HT6 receptor expressed in human HeLa cells assessed as inhibition of 5HT-induced cyclic AMP formation relative to SB-271047 | ChEMBL. | 21093272 |
Ki (binding) | = 1.1 nM | Displacement of [3H]-LSD from cloned human 5-HT6 receptor expressed in human HeLa cells | ChEMBL. | 21093272 |
Ki (binding) | = 33 nM | Binding affinity to 5-HT2B receptor | ChEMBL. | 21093272 |
Ki (binding) | = 1340 nM | Binding affinity to 5-HT1D receptor | ChEMBL. | 21093272 |
Ki (binding) | = 3011 nM | Binding affinity to 5-HT1A receptor | ChEMBL. | 21093272 |
Ki (binding) | > 5000 nM | Binding affinity to 5-HT1B receptor | ChEMBL. | 21093272 |
Ki (binding) | > 5000 nM | Binding affinity to 5-HT2C receptor | ChEMBL. | 21093272 |
Ki (binding) | > 5000 nM | Binding affinity to 5-HT7 receptor | ChEMBL. | 21093272 |
Ki (binding) | > 5000 nM | Binding affinity to adrenergic alpha2A receptor | ChEMBL. | 21093272 |
Ki (binding) | > 5000 nM | Binding affinity to dopamine D2 receptor | ChEMBL. | 21093272 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.