Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Brugia malayi | Pre-SET motif family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Onchocerca volvulus | Get druggable targets OG5_131470 | All targets in OG5_131470 | |
Trichomonas vaginalis | set domain proteins, putative | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0095 | 0.1123 | 0.1123 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1123 | 0.1123 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1123 | 0.1123 |
Echinococcus granulosus | acetylcholinesterase | 0.0565 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0095 | 0.1123 | 0.1123 |
Echinococcus granulosus | neuroligin | 0.0095 | 0.1123 | 0.1123 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.4068 | 0.4068 |
Loa Loa (eye worm) | carboxylesterase | 0.0095 | 0.1123 | 0.1123 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0095 | 0.1123 | 0.1123 |
Brugia malayi | hypothetical protein | 0.0095 | 0.1123 | 0.1123 |
Loa Loa (eye worm) | hypothetical protein | 0.0565 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0095 | 0.1123 | 0.1123 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0565 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0565 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0565 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1123 | 0.1123 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1123 | 0.1123 |
Onchocerca volvulus | 0.0095 | 0.1123 | 0.2378 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0095 | 0.1123 | 0.1123 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0565 | 1 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.4068 | 0.4068 |
Echinococcus multilocularis | acetylcholinesterase | 0.0565 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0095 | 0.1123 | 0.1123 |
Brugia malayi | Carboxylesterase family protein | 0.0095 | 0.1123 | 0.1123 |
Onchocerca volvulus | 0.0095 | 0.1123 | 0.2378 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0565 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1123 | 0.1123 |
Onchocerca volvulus | 0.0095 | 0.1123 | 0.2378 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0095 | 0.1123 | 0.1123 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0095 | 0.1123 | 0.1123 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1123 | 0.1123 |
Schistosoma mansoni | acetylcholinesterase | 0.0095 | 0.1123 | 0.1123 |
Onchocerca volvulus | 0.0095 | 0.1123 | 0.2378 | |
Onchocerca volvulus | 0.0095 | 0.1123 | 0.2378 | |
Plasmodium vivax | SET domain protein, putative | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0565 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0095 | 0.1123 | 0.1123 |
Onchocerca volvulus | 0.0286 | 0.4725 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0095 | 0.1123 | 0.1123 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0095 | 0.1123 | 0.1123 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1123 | 0.1123 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0095 | 0.1123 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0095 | 0.1123 | 0.1123 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0095 | 0.1123 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0565 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0565 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0095 | 0.1123 | 0.1123 |
Schistosoma mansoni | gliotactin | 0.0095 | 0.1123 | 0.1123 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0095 | 0.1123 | 0.1123 |
Brugia malayi | Carboxylesterase family protein | 0.0095 | 0.1123 | 0.1123 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0095 | 0.1123 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0565 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0095 | 0.1123 | 0.1123 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.4725 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0095 | 0.1123 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.