Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Homo sapiens | vitamin D (1,25- dihydroxyvitamin D3) receptor | Starlite/ChEMBL | No references |
Homo sapiens | polo-like kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | steroid hormone receptor | vitamin D (1,25- dihydroxyvitamin D3) receptor | 427 aa | 416 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.7899 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0114 | 0.7899 | 0.5 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0043 | 0.0742 | 0.0742 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.5649 | 0.5649 |
Brugia malayi | jmjC domain containing protein | 0.0043 | 0.0742 | 0.0742 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.7899 | 1 |
Toxoplasma gondii | apocytochrome b, putative | 0.0135 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.7899 | 0.7899 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0742 | 0.0742 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2519 | 0.2519 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.3755 | 0.3755 |
Brugia malayi | jmjC domain containing protein | 0.0115 | 0.8023 | 0.8023 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0114 | 0.7899 | 0.7899 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0043 | 0.0742 | 0.0742 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.7899 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.241 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.7899 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.241 | 0.241 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0115 | 0.8023 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0114 | 0.7899 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0043 | 0.0742 | 0.0742 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0115 | 0.8023 | 0.8023 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0114 | 0.7899 | 0.9845 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.241 | 0.3003 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.7899 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.1381 | 0.1721 |
Plasmodium vivax | cytochrome b | 0.0135 | 1 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.1381 | 0.1381 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.241 | 0.241 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0114 | 0.7899 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.241 | 0.241 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.241 | 0.5 |
Toxoplasma gondii | cytochrome b | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0114 | 0.7899 | 0.7899 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.241 | 0.5 |
Schistosoma mansoni | kinase | 0.0058 | 0.228 | 0.228 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0114 | 0.7899 | 0.7899 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0114 | 0.7899 | 0.5 |
Echinococcus granulosus | cytochrome B | 0.0135 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.241 | 0.5 |
Trypanosoma brucei | polo-like protein kinase | 0.0114 | 0.7899 | 0.5 |
Schistosoma mansoni | cytochrome b | 0.0135 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0135 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome b | 0.0135 | 1 | 1 |
Plasmodium falciparum | cytochrome b | 0.0135 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.7899 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.241 | 0.241 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.7899 | 1 |
Schistosoma mansoni | cytochrome b | 0.0135 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0114 | 0.7899 | 1 |
Giardia lamblia | Kinase, PLK | 0.0114 | 0.7899 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.0742 | 0.0925 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.9728 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.