Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.2822 | 0.3598 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2822 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0351 | 0.0448 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.3249 | 0.2673 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3262 | 0.3541 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7186 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.2822 | 0.3615 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7186 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.9213 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.2822 | 0.3615 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2822 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.7844 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2822 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3698 | 0.4014 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.4049 | 0.4395 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2822 | 0.3598 |
Brugia malayi | hypothetical protein | 0.0043 | 0.2822 | 0.2209 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2814 | 0.3603 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2814 | 0.3603 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2822 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 6.5131 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.