Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0496 | 0.0859 | 0.0859 |
Onchocerca volvulus | 0.0496 | 0.0859 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.0859 | 0.0859 |
Loa Loa (eye worm) | hypothetical protein | 0.2938 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0496 | 0.0859 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0496 | 0.0859 | 0.0859 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0496 | 0.0859 | 0.0859 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0496 | 0.0859 | 0.0859 |
Loa Loa (eye worm) | hypothetical protein | 0.2938 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.2938 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0496 | 0.0859 | 0.0859 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0496 | 0.0859 | 0.0859 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.0859 | 0.0859 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.0859 | 0.0859 |
Onchocerca volvulus | 0.0496 | 0.0859 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0496 | 0.0859 | 0.0859 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2938 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0496 | 0.0859 | 0.5 |
Onchocerca volvulus | 0.0496 | 0.0859 | 0.5 | |
Onchocerca volvulus | 0.0496 | 0.0859 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.0859 | 0.0859 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.0859 | 0.0859 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0496 | 0.0859 | 0.0859 |
Echinococcus multilocularis | acetylcholinesterase | 0.2938 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0496 | 0.0859 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.0859 | 0.0859 |
Echinococcus granulosus | acetylcholinesterase | 0.2938 | 1 | 1 |
Onchocerca volvulus | 0.0496 | 0.0859 | 0.5 | |
Schistosoma mansoni | acetylcholinesterase | 0.0496 | 0.0859 | 0.0859 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0496 | 0.0859 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2938 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0496 | 0.0859 | 0.0859 |
Brugia malayi | Carboxylesterase family protein | 0.0496 | 0.0859 | 0.0859 |
Echinococcus multilocularis | acetylcholinesterase | 0.2938 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0496 | 0.0859 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.2938 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.2938 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.2938 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0496 | 0.0859 | 0.0859 |
Brugia malayi | Carboxylesterase family protein | 0.0496 | 0.0859 | 0.0859 |
Loa Loa (eye worm) | carboxylesterase | 0.0496 | 0.0859 | 0.0859 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2938 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0496 | 0.0859 | 1 |
Schistosoma mansoni | gliotactin | 0.0496 | 0.0859 | 0.0859 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Effect (functional) | 0 | Evaluated for antiviral activity against cutaneous HSV-1 C42 infections in guinea pig; Not active | ChEMBL. | 6298425 |
IC50 (binding) | > 500 uM | Inhibition of HSV-1 DNA polymerase in HSV-1 C42 plaque reduction assay | ChEMBL. | 6298425 |
IC50 (binding) | > 500 uM | Inhibition of HSV-1 DNA polymerase in HSV-1 C42 plaque reduction assay | ChEMBL. | 6298425 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.