Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Ovis aries | Cyclooxygenase-1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cathepsin L-like protease | 0.0318 | 1 | 0.5 |
Onchocerca volvulus | Cathepsin F homolog | 0.0318 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0318 | 1 | 1 |
Onchocerca volvulus | 0.0318 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0318 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0318 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0318 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0164 | 0.2757 | 0.2757 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0164 | 0.2757 | 0.2757 |
Brugia malayi | Cathepsin L-like precursor | 0.0318 | 1 | 1 |
Plasmodium vivax | unspecified product | 0.0164 | 0.2757 | 0.2757 |
Echinococcus granulosus | cathepsin l1 | 0.0213 | 0.5061 | 0.3182 |
Onchocerca volvulus | Cathepsin L homolog | 0.0318 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0318 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0318 | 1 | 1 |
Plasmodium vivax | vivapain-1 | 0.0164 | 0.2757 | 0.2757 |
Loa Loa (eye worm) | ctsf protein | 0.0318 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0318 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0213 | 0.5061 | 0.5061 |
Echinococcus granulosus | cathepsin l1 | 0.0318 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0164 | 0.2757 | 0.2757 |
Trypanosoma cruzi | cysteine protease, putative | 0.0164 | 0.2757 | 0.2757 |
Onchocerca volvulus | Cathepsin L homolog | 0.0318 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0318 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0318 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0318 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.5061 | 0.5061 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0164 | 0.2757 | 0.2757 |
Leishmania major | cathepsin L-like protease | 0.0318 | 1 | 0.5 |
Onchocerca volvulus | 0.0318 | 1 | 1 | |
Plasmodium vivax | vivapain-2 | 0.0318 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0318 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0318 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0318 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0318 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0318 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0318 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0318 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0213 | 0.5061 | 0.5061 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0318 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0318 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0318 | 1 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0318 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0318 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0318 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0318 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0213 | 0.5061 | 0.5061 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0318 | 1 | 1 |
Plasmodium vivax | vivapain-3 | 0.0164 | 0.2757 | 0.2757 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0164 | 0.2757 | 0.2757 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0318 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0318 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0318 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0318 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0318 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0318 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0164 | 0.2757 | 0.2757 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0318 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0213 | 0.5061 | 0.5061 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0318 | 1 | 1 |
Onchocerca volvulus | 0.0318 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.5061 | 0.5061 |
Leishmania major | cathepsin L-like protease | 0.0318 | 1 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0213 | 0.5061 | 0.5061 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 1 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0318 | 1 | 0.5 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0318 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0213 | 0.5061 | 0.3182 |
Leishmania major | cysteine peptidase A (CPA) | 0.0318 | 1 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0318 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0318 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0318 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0318 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0318 | 1 | 0.5 |
Onchocerca volvulus | 0.0318 | 1 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0318 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0318 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.5061 | 0.5061 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0318 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0318 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0318 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0213 | 0.5061 | 0.3182 |
Onchocerca volvulus | 0.0318 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0318 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0318 | 1 | 0.5 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0318 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0318 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0318 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0318 | 1 | 0.5 |
Brugia malayi | cathepsin L-like precursor | 0.0213 | 0.5061 | 0.5061 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0164 | 0.2757 | 0.2757 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0318 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0318 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0318 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0318 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0318 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0318 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0318 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0318 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0164 | 0.2757 | 0.2757 |
Onchocerca volvulus | 0.0318 | 1 | 1 | |
Onchocerca volvulus | 0.0318 | 1 | 1 | |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0164 | 0.2757 | 0.2757 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0213 | 0.5061 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0318 | 1 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0318 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.