Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | synuclein, alpha (non A4 component of amyloid precursor) | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | breast cancer 1, early onset | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | galanin receptor 3 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.5667 | 0.5667 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.5667 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.1877 | 0.3312 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5667 | 0.9081 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.012 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.624 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1877 | 0.3008 |
Echinococcus multilocularis | GPCR, family 2 | 0.0038 | 0.1877 | 0.3312 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2405 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0038 | 0.1877 | 0.1877 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1877 | 0.3008 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5667 | 0.9081 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1877 | 0.3008 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1877 | 0.3008 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.2405 | 0.3854 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5667 | 0.9081 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.5667 | 0.5667 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.5667 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.1877 | 0.3312 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0019 | 0 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0038 | 0.1877 | 0.1877 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2405 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.2405 | 0.2405 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.2405 | 0.4244 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.012 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.5667 | 0.5667 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5667 | 0.9081 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5667 | 0.9081 |
Echinococcus granulosus | GPCR family 2 | 0.0038 | 0.1877 | 0.3312 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0082 | 0.624 | 0.624 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.1877 | 0.3312 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.1877 | 0.3312 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2405 | 0.3854 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.5667 | 0.5667 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0038 | 0.1877 | 0.1877 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.624 | 0.624 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.5667 | 0.5667 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.5667 | 0.5667 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2405 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.2405 | 0.4244 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2405 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1877 | 0.1877 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AbsAC1 (functional) | = 6.55 uM | PubChem BioAssay. Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy Measured in Biochemical System Using RT-PCR - 7012-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
AbsAC1000_uM (functional) | = 4.477 uM | PUBCHEM_BIOASSAY: In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504552] | ChEMBL. | No reference |
AbsAC40_uM (functional) | 3.87 uM | PubChem BioAssay. In vivo-based yeast HTS counterscreen to detect compounds rescuing yeast growth/survival of Saccharomyces cerevisiae SKN7-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | = 0.6261 uM | PubChem BioAssay. Fluorescence-based cell-based primary high throughput dose response assay to identify antagonists of the Galanin Receptor 3 (GalR3). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.6513 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.7667 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.2589 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.6626 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 3.6626 uM | PubChem BioAssay. Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.