Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1963 | 0.5833 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1963 | 0.4979 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1028 | 0.0911 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1351 | 0.4014 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1192 | 0.3541 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0128 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.3366 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0903 | 0.2684 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1963 | 0.5833 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.2866 | 0.2866 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1963 | 0.4979 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.3653 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.1187 | 0.2673 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2625 | 0.2529 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2625 | 0.2529 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0903 | 0.183 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0903 | 0.0903 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1028 | 0.0911 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1479 | 0.4395 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.9185 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.