TDR Targets

Basic information

Technical information

TDR Targets ID: 1503449
Name: ZINC00117115
MW: 332.444 | Formula: C15H16N4OS2
H donors: 2 H acceptors: 3 LogP: 4.52 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1cccs1)NNc1ncnc2c1sc(c2)C(C)(C)C
InChi: 1S/C15H16N4OS2/c1-15(2,3)11-7-9-12(22-11)13(17-8-16-9)18-19-14(20)10-5-4-6-21-10/h4-8H,1-3H3,(H,19,20)(H,16,17,18)
InChiKey: LHEIEBRYULRKII-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania donovani	hypothetical protein, conserved	Get druggable targets OG5_154436	All targets in OG5_154436
Leishmania mexicana	hypothetical protein, conserved	Get druggable targets OG5_154436	All targets in OG5_154436
Trypanosoma congolense	3', 5'-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_154436	All targets in OG5_154436
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_154436	All targets in OG5_154436
Leishmania major	hypothetical protein, conserved	Get druggable targets OG5_154436	All targets in OG5_154436
Trypanosoma brucei gambiense	3, 5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_154436	All targets in OG5_154436
Leishmania infantum	hypothetical protein, conserved	Get druggable targets OG5_154436	All targets in OG5_154436
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	Get druggable targets OG5_154436	All targets in OG5_154436
Leishmania braziliensis	hypothetical protein, conserved	Get druggable targets OG5_154436	All targets in OG5_154436

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0154	0.4983
Giardia lamblia	Alpha-tubulin	0.0018	0.031	1
Plasmodium falciparum	alpha tubulin 1	0.0018	0.031	1
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0014	0.0154	0.0154
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0154	0.4983
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0014	0.0154	0.0154
Brugia malayi	metabotropic glutamate receptor type 2	0.0025	0.0594	0.3716
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0014	0.0154	0.0753
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0018	0.031	0.151
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0154	0.4983
Echinococcus granulosus	Tubulin alpha 1 chain	0.0018	0.031	0.151
Leishmania major	alpha tubulin	0.0018	0.031	0.031
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0014	0.0154	0.0154
Loa Loa (eye worm)	tubulin alpha chain	0.0018	0.031	0.151
Echinococcus multilocularis	tubulin alpha chain	0.0018	0.031	0.151
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0154	0.4983
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0154	0.0753
Echinococcus granulosus	peroxisome assembly protein 26	0.0018	0.031	0.151
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0154	0.4983
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0154	0.0753
Schistosoma mansoni	metabotropic glutamate receptor	0.0043	0.1281	0.6858
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0153	0.0746
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0014	0.0154	0.0827
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0014	0.0154	0.0753
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.0154	0.0154
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0154	0.0154
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0014	0.0154	0.0154
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0014	0.0154	0.0753
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.0154	0.0154
Echinococcus granulosus	tubulin alpha 1C chain	0.0018	0.031	0.151
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0012	0.0106	0.0514
Leishmania major	alpha tubulin	0.0018	0.031	0.031
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0014	0.0154	0.0154
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0014	0.0154	0.0827
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0014	0.0154	0.4983
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0014	0.0154	0.0753
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0014	0.0154	0.0154
Echinococcus multilocularis	tubulin alpha 3 chain	0.0018	0.031	0.151
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0014	0.0154	0.0154
Leishmania major	alpha tubulin	0.0018	0.031	0.031
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0154	0.4983
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0043	0.1281	0.6242
Loa Loa (eye worm)	alpha-tubulin	0.0018	0.031	0.151
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0141	0.0688
Brugia malayi	tubulin alpha-2 chain	0.0018	0.031	0.1938
Loa Loa (eye worm)	alpha-tubulin	0.0018	0.031	0.151
Schistosoma mansoni	metabotropic glutamate receptor	0.0025	0.0594	0.3182
Echinococcus multilocularis	tubulin alpha 1C chain	0.0018	0.031	0.151
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0014	0.0154	0.4983
Brugia malayi	Tubulin alpha-2 chain	0.0018	0.031	0.1938
Brugia malayi	Tubulin alpha-2 chain	0.0018	0.031	0.1938
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0014	0.0154	0.0753
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0014	0.0154	0.4983
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.0154	0.0154
Toxoplasma gondii	alpha tubulin TUBA1	0.0018	0.031	1
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0014	0.0154	0.0753
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0154	0.4983
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0154	0.0753
Loa Loa (eye worm)	glutamate receptor	0.002	0.041	0.1998
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Echinococcus granulosus	tubulin alpha chain	0.0018	0.031	0.151
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0154	0.4983
Echinococcus multilocularis	tubulin alpha chain	0.0018	0.031	0.151
Echinococcus granulosus	tubulin alpha 3 chain	0.0018	0.031	0.151
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0014	0.0154	0.0753
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0154	0.4983
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0014	0.0154	0.0154
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0154	0.4983
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Leishmania major	alpha tubulin	0.0018	0.031	0.031
Echinococcus multilocularis	tubulin alpha chain	0.0018	0.031	0.151
Loa Loa (eye worm)	PDE1B protein	0.0014	0.0154	0.0753
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0154	0.4983
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0014	0.0154	0.0966
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0154	0.4983
Echinococcus granulosus	tubulin alpha chain	0.0018	0.031	0.151
Trypanosoma cruzi	alpha tubulin, putative	0.0018	0.031	0.031
Leishmania major	alpha tubulin	0.0018	0.031	0.031
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0014	0.0154	0.4983
Brugia malayi	alpha-tubulin	0.0018	0.031	0.1938
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.0154	0.0154
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0014	0.0154	0.0753
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0014	0.0154	0.0154
Leishmania major	alpha tubulin	0.0018	0.031	0.031
Entamoeba histolytica	tubulin alpha chain, putative	0.0018	0.031	1
Echinococcus granulosus	tubulin subunit TubB	0.0018	0.031	0.151
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0014	0.0154	0.0154
Trypanosoma brucei	alpha tubulin	0.0018	0.031	0.031
Echinococcus granulosus	tubulin alpha 3 chain	0.0018	0.031	0.151
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0014	0.0154	0.0827
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0014	0.0154	0.0753
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0154	0.4983
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0014	0.0154	0.4983
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0018	0.031	0.151
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0014	0.0154	0.0827
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0154	0.4983
Schistosoma mansoni	tubulin subunit alpha	0.0018	0.031	0.166
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0014	0.0154	0.4983
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0154	0.4983
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0014	0.0154	0.0827
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0018	0.031	1
Trypanosoma brucei	hypothetical protein, conserved	0.0014	0.0154	0.0154
Leishmania major	alpha tubulin	0.0018	0.031	0.031
Giardia lamblia	Hypothetical protein	0.0014	0.0154	0.4983
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0154	0.4983
Schistosoma mansoni	tubulin subunit alpha	0.0018	0.031	0.166
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0052	0.1599	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0154	0.4983
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0014	0.0154	0.4983
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0014	0.0154	0.4983
Leishmania major	alpha tubulin	0.0018	0.031	0.031
Echinococcus multilocularis	hypothetical protein	0.0018	0.031	0.151
Echinococcus granulosus	Tubulin alpha 1 chain	0.0018	0.031	0.151
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0014	0.0154	0.0753
Trypanosoma brucei	alpha tubulin	0.0018	0.031	0.031
Brugia malayi	Receptor family ligand binding region containing protein	0.0013	0.0141	0.0883
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0014	0.0154	0.0753
Leishmania major	hypothetical protein, conserved	0.0014	0.0154	0.0154
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0014	0.0153	0.0746
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0059	0.1867	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0014	0.0154	0.0827
Echinococcus multilocularis	tubulin alpha 3 chain	0.0018	0.031	0.151
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0014	0.0154	0.0827
Echinococcus granulosus	tubulin alpha chain	0.0018	0.031	0.151
Giardia lamblia	Alpha-tubulin	0.0018	0.031	1
Brugia malayi	Tubulin alpha chain	0.0018	0.031	0.1938
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0154	0.4983
Plasmodium vivax	tubulin alpha chain, putative	0.0018	0.031	1
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0018	0.031	1
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0273	1	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0154	0.4983
Trypanosoma brucei	alpha tubulin	0.0018	0.031	0.031
Schistosoma mansoni	alpha tubulin	0.0018	0.031	0.166
Plasmodium vivax	tubulin alpha chain, putative	0.0018	0.031	1
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Schistosoma mansoni	alpha tubulin	0.0018	0.031	0.166
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0154	0.4983
Echinococcus granulosus	tubulin alpha 1C chain	0.0018	0.031	0.151
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0154	0.4983
Echinococcus multilocularis	tubulin alpha chain	0.0018	0.031	0.151
Plasmodium falciparum	alpha tubulin 2	0.0018	0.031	1
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0014	0.0154	0.0154
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0014	0.0154	0.4983
Leishmania major	alpha tubulin	0.0018	0.031	0.031
Trichomonas vaginalis	tubulin beta chain, putative	0.0018	0.031	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0018	0.031	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0014	0.0153	0.494
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0154	0.4983
Echinococcus multilocularis	peroxisome assembly protein 26	0.0018	0.031	0.151
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0014	0.0154	0.4983
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0014	0.0154	0.0753
Plasmodium vivax	phosphodiesterase gamma, putative	0.0014	0.0154	0.4983
Trichomonas vaginalis	tubulin beta chain, putative	0.0018	0.031	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0014	0.0154	0.4983
Loa Loa (eye worm)	tubulin alpha 2	0.0014	0.0153	0.0746
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0106	0.0514
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0014	0.0154	0.0753
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0154	0.4983
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0014	0.0154	0.0753
Leishmania major	alpha tubulin	0.0018	0.031	0.031
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0014	0.0154	0.0827
Echinococcus multilocularis	tubulin subunit TubB	0.0018	0.031	0.151
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0154	0.4983
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0014	0.0154	0.0966
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Schistosoma mansoni	alpha tubulin	0.0018	0.031	0.166
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0154	0.4983
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.0154	0.0154
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0014	0.0154	0.0753
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0014	0.0154	0.0753
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0047	0.1415	0.8847
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0012	0.0106	0.3406
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0013	0.0141	0.0688
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0014	0.0154	0.0753
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0273	1	1
Loa Loa (eye worm)	glutamate receptor	0.0052	0.1599	0.7792
Trypanosoma brucei	alpha tubulin	0.0018	0.031	0.031
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0154	0.4983
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0014	0.0154	0.0827
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0064	0.2052	1
Echinococcus granulosus	tubulin alpha chain	0.0018	0.031	0.151
Echinococcus multilocularis	tubulin alpha 1C chain	0.0018	0.031	0.151
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0018	0.031	0.151
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0064	0.2052	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0018	0.031	1
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0014	0.0154	0.0966
Leishmania major	alpha tubulin	0.0018	0.031	0.031
Loa Loa (eye worm)	hypothetical protein	0.0018	0.031	0.151
Trichomonas vaginalis	tubulin beta chain, putative	0.0018	0.031	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0154	0.4983
Plasmodium falciparum	phosphodiesterase delta, putative	0.0014	0.0154	0.4983
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0018	0.031	0.151
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0154	0.4983
Loa Loa (eye worm)	hypothetical protein	0.0064	0.2052	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0018	0.031	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0018	0.031	0.151
Leishmania major	alpha tubulin	0.0018	0.031	0.031
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0154	0.4983
Schistosoma mansoni	tubulin subunit alpha	0.0018	0.031	0.166
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0014	0.0154	0.0827
Giardia lamblia	hypothetical protein	0.0014	0.0154	0.4983
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0014	0.0154	0.0827
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0043	0.1281	0.6242
Entamoeba histolytica	tubulin alpha-1 chain	0.0018	0.031	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0154	0.0753
Echinococcus granulosus	tubulin alpha chain	0.0018	0.031	0.151
Echinococcus multilocularis	tubulin alpha chain	0.0018	0.031	0.151
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0018	0.031	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0014	0.0154	0.0966
Brugia malayi	tubulin alpha chain - mouse	0.0018	0.031	0.1938
Loa Loa (eye worm)	tubulin alpha 2	0.0014	0.0153	0.0746
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0154	0.4983
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0014	0.0154	0.4983
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0014	0.0154	0.0154
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0154	0.4983
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0014	0.0154	0.4983
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0154	0.4983
Loa Loa (eye worm)	tubulin alpha chain	0.0018	0.031	0.151
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0013	0.0141	0.0688
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0154	0.4983
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0014	0.0154	0.4983
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.0154	0.0154
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0014	0.0154	0.0966
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0014	0.0154	0.0966
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0014	0.0154	0.4983
Echinococcus granulosus	alpha tubulin	0.0018	0.031	0.151
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0014	0.0154	0.0154
Toxoplasma gondii	alpha-tubulin I, putative	0.0018	0.031	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 4.8 uM	Antimicrobial activity against Trypanosoma cruzi Y infected in rat L6E9 myoblasts assessed as inhibition of [5,6-3H]uracil incorporation after 3 days postinfection by scintillation counter	ChEMBL.	20625148
IC50 (binding)	= 6.3 uM	Inhibition of Trypanosoma cruzi Y PDEC after 30 mins	ChEMBL.	20625148

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Trypanosoma cruzi	ChEMBL23	20625148

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1673329

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1503449