Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 1 | Starlite/ChEMBL | References |
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | IMP dehydrogenas | 0.019 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0097 | 0.2794 | 0.104 |
Entamoeba histolytica | histone deacetylase, putative | 0.0087 | 0.1958 | 0.5 |
Trypanosoma brucei | histone deacetylase 3 | 0.0097 | 0.2794 | 0.104 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0178 | 0.912 | 0.8869 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0103 | 0.327 | 0.1632 |
Echinococcus granulosus | histone deacetylase 7 | 0.0097 | 0.2794 | 0.104 |
Brugia malayi | Histone deacetylase family protein | 0.0097 | 0.2794 | 0.1683 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0087 | 0.1958 | 0.1958 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0087 | 0.1958 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0087 | 0.1958 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0097 | 0.2794 | 0.104 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0178 | 0.912 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0103 | 0.327 | 0.1632 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0087 | 0.1958 | 0.5 |
Leishmania major | guanosine monophosphate reductase | 0.019 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0097 | 0.2794 | 0.104 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0087 | 0.1958 | 0.5 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.019 | 1 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.0087 | 0.1958 | 0.0717 |
Brugia malayi | Histone deacetylase family protein | 0.0097 | 0.2794 | 0.1683 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0087 | 0.1958 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0087 | 0.1958 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.019 | 1 | 1 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.019 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0087 | 0.1958 | 0.5 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0097 | 0.2794 | 0.104 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0087 | 0.1958 | 0.0717 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0097 | 0.2794 | 0.104 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.019 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0097 | 0.2794 | 0.104 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0097 | 0.2794 | 0.104 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.1958 | 0.1958 |
Loa Loa (eye worm) | histone deacetylase | 0.0097 | 0.2794 | 0.2794 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0097 | 0.2794 | 0.2794 |
Loa Loa (eye worm) | GMP reductase | 0.0079 | 0.1336 | 0.1336 |
Giardia lamblia | Histone deacetylase | 0.0087 | 0.1958 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0097 | 0.2794 | 0.104 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.019 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase | 0.0097 | 0.2794 | 0.104 |
Echinococcus granulosus | histone deacetylase 6 | 0.0103 | 0.327 | 0.1632 |
Echinococcus granulosus | histone deacetylase 6 | 0.0097 | 0.2794 | 0.104 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.019 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0097 | 0.2794 | 0.104 |
Echinococcus granulosus | histone deacetylase | 0.0097 | 0.2794 | 0.104 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0087 | 0.1958 | 0.5 |
Plasmodium falciparum | histone deacetylase 2 | 0.0097 | 0.2794 | 0.1167 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.019 | 1 | 0.5 |
Trypanosoma brucei | GMP reductase | 0.019 | 1 | 1 |
Trypanosoma brucei | histone deacetylase, putative | 0.0097 | 0.2794 | 0.104 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.019 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0087 | 0.1958 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.019 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0087 | 0.1958 | 0.1958 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.019 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.019 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0097 | 0.2794 | 0.104 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0087 | 0.1958 | 0.0717 |
Onchocerca volvulus | Putative GMP reductase | 0.0079 | 0.1336 | 0.5 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0097 | 0.2794 | 0.104 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.01 | 0.2959 | 0.0954 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.019 | 1 | 1 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.019 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 4 | 0.0097 | 0.2794 | 0.104 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0097 | 0.2794 | 0.1167 |
Plasmodium falciparum | histone deacetylase, putative | 0.0097 | 0.2794 | 0.1167 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.019 | 1 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.019 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0097 | 0.2794 | 0.104 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0178 | 0.912 | 1 |
Plasmodium vivax | histone deacetylase, putative | 0.0097 | 0.2794 | 0.1167 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 4 uM | Antiproliferative activity against human K562 cells after 72 hrs by MTS assay | ChEMBL. | 21324702 |
Ki (binding) | = 73 nM | Inhibition of human IMPDH2 by Spectrophotometer | ChEMBL. | 21324702 |
Ki (binding) | = 99 nM | Inhibition of human IMPDH1 by Spectrophotometry | ChEMBL. | 21324702 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21324702 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.