TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 498.595 | Formula: C25H30N4O5S
H donors: 0 H acceptors: 3 LogP: 2.31 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCOCCOc1c(cnn(c1=O)c1ccccc1)N1CCN(CC1)S(=O)(=O)Cc1ccccc1
InChi: 1S/C25H30N4O5S/c1-2-33-17-18-34-24-23(19-26-29(25(24)30)22-11-7-4-8-12-22)27-13-15-28(16-14-27)35(31,32)20-21-9-5-3-6-10-21/h3-12,19H,2,13-18,20H2,1H3
InChiKey: XNZIFXFXKFOZAJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Candida albicans	beta-1,3-glucan synthase similar to S. cerevisiae GSC2 (YGR032W) and FKS1 (YLR342W) beta-1,3-glucan synthase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	similar to S. cerevisiae FKS3 (YMR306W) 1,3-beta glucan synthase	Get druggable targets OG5_127693	All targets in OG5_127693
Candida albicans	N terminus of glucan synthase	Get druggable targets OG5_127693	All targets in OG5_127693
Candida albicans	C terminus of glucan synthase	Get druggable targets OG5_127693	All targets in OG5_127693
Toxoplasma gondii	1,3-beta-glucan synthase component protein	Get druggable targets OG5_127693	All targets in OG5_127693
Candida albicans	beta-1,3-glucan synthase similar to S. cerevisiae GSC2 (YGR032W) and FKS1 (YLR342W) beta-1,3-glucan synthase	Get druggable targets OG5_127693	All targets in OG5_127693
Candida albicans	glucan synthase	Get druggable targets OG5_127693	All targets in OG5_127693
Candida albicans	beta-1,3-glucan synthase similar to S. cerevisiae GSC2 (YGR032W) and FKS1 (YLR342W) beta-1,3-glucan synthase	Get druggable targets OG5_127693	All targets in OG5_127693
Candida albicans	N terminus of glucan synthase	Get druggable targets OG5_127693	All targets in OG5_127693
Neospora caninum	hypothetical protein	Get druggable targets OG5_127693	All targets in OG5_127693
Candida albicans	C terminus of glucan synthase	Get druggable targets OG5_127693	All targets in OG5_127693

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0638	0.0638
Echinococcus granulosus	7TM GPCR rhodopsin	0.0231	0.3644	1
Echinococcus granulosus	twitchin	0.0046	0.043	0.118
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Brugia malayi	putative neuropeptide receptor	0.0231	0.3644	0.3644
Echinococcus multilocularis	Immunoglobulin	0.0037	0.0267	0.0733
Echinococcus multilocularis	neuropeptides capa receptor	0.0231	0.3644	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0231	0.3644	0.3644
Echinococcus granulosus	g protein coupled receptor	0.0231	0.3644	1
Onchocerca volvulus		0.0231	0.3644	0.3911
Echinococcus granulosus	rhodopsin orphan GPCR	0.0231	0.3644	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0231	0.3644	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0231	0.3644	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0231	0.3644	0.3911
Echinococcus granulosus	rhodopsin orphan GPCR	0.0231	0.3644	1
Onchocerca volvulus		0.0231	0.3644	0.3911
Echinococcus granulosus	neuroglian	0.0046	0.043	0.118
Loa Loa (eye worm)	melatonin receptor type 1A	0.0231	0.3644	0.3644
Brugia malayi	hypothetical protein	0.0231	0.3644	0.3644
Onchocerca volvulus		0.0231	0.3644	0.3911
Echinococcus multilocularis	neuropeptide receptor A26	0.0231	0.3644	1
Onchocerca volvulus		0.0231	0.3644	0.3911
Brugia malayi	GnHR receptor homolog	0.0231	0.3644	0.3644
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0231	0.3644	0.3644
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0231	0.3644	0.3644
Schistosoma mansoni	hypothetical protein	0.0175	0.2675	0.7341
Schistosoma mansoni	hypothetical protein	0.0054	0.0559	0.1533
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0231	0.3644	1
Echinococcus granulosus	neuropeptides capa receptor	0.0231	0.3644	1
Onchocerca volvulus		0.0231	0.3644	0.3911
Schistosoma mansoni	biogenic amine receptor	0.0231	0.3644	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Echinococcus multilocularis	serotonin receptor	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0231	0.3644	0.3644
Brugia malayi	neuropeptide F receptor	0.0231	0.3644	0.3644
Echinococcus granulosus	neuropeptide s receptor	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0267	0.0267
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0231	0.3644	1
Echinococcus multilocularis	g protein coupled receptor	0.0231	0.3644	1
Brugia malayi	Dopamine receptor protein 1	0.0231	0.3644	0.3644
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0638	0.0638
Echinococcus granulosus	rhodopsin orphan GPCR	0.0231	0.3644	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0231	0.3644	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0231	0.3644	1
Brugia malayi	RE15519p	0.0231	0.3644	0.3644
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0267	0.0267
Onchocerca volvulus	Tyrosine kinase homolog	0.0558	0.9317	1
Echinococcus granulosus	sex peptide receptor	0.0231	0.3644	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0231	0.3644	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0597	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0231	0.3644	1
Echinococcus granulosus	neuropeptide receptor	0.0231	0.3644	1
Schistosoma mansoni	amine GPCR	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0267	0.0267
Echinococcus granulosus	rhodopsin orphan GPCR	0.0231	0.3644	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0231	0.3644	1
Schistosoma mansoni	neuropeptide receptor	0.0231	0.3644	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0231	0.3644	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0231	0.3644	1
Echinococcus granulosus	Immunoglobulin	0.0037	0.0267	0.0733
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0231	0.3644	1
Schistosoma mansoni	neuropeptide receptor	0.0231	0.3644	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0231	0.3644	0.3644
Echinococcus granulosus	g-protein coupled receptor	0.0231	0.3644	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Brugia malayi	Dopamine receptor protein 2	0.0231	0.3644	0.3644
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Brugia malayi	G protein-coupled receptor F59B2.13	0.0231	0.3644	0.3644
Echinococcus granulosus	rhodopsin orphan GPCR	0.0231	0.3644	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0231	0.3644	1
Echinococcus granulosus	g protein coupled receptor	0.0231	0.3644	1
Echinococcus multilocularis	sex peptide receptor	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Schistosoma mansoni	vesicular amine transporter	0.0037	0.0267	0.0733
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Onchocerca volvulus		0.0231	0.3644	0.3911
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0231	0.3644	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0231	0.3644	1
Echinococcus granulosus	neuropeptide Y receptor	0.0231	0.3644	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0231	0.3644	0.3644
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0231	0.3644	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0231	0.3644	0.3644
Echinococcus multilocularis	nmda type glutamate receptor	0.0026	0.0088	0.0242
Echinococcus granulosus	somatostatin receptor	0.0231	0.3644	1
Echinococcus multilocularis	neuropeptide receptor	0.0231	0.3644	1
Echinococcus multilocularis	somatostatin receptor	0.0231	0.3644	1
Brugia malayi	hypothetical protein	0.0037	0.0267	0.0267
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0231	0.3644	1
Brugia malayi	Fibronectin type III domain containing protein	0.0037	0.0267	0.0267
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0231	0.3644	1
Schistosoma mansoni	hypothetical protein	0.0231	0.3644	1
Echinococcus multilocularis	serotonin receptor	0.0231	0.3644	1
Schistosoma mansoni	amine GPCR	0.0231	0.3644	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Schistosoma mansoni	cell adhesion molecule	0.0049	0.0475	0.1304
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0037	0.0267	0.0733
Brugia malayi	hypothetical protein	0.0231	0.3644	0.3644
Onchocerca volvulus		0.0231	0.3644	0.3911
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0231	0.3644	1
Echinococcus granulosus	hypothetical protein	0.0231	0.3644	1
Schistosoma mansoni	hypothetical protein	0.0175	0.2675	0.7341
Echinococcus granulosus	dro:myosuppressin receptor	0.0231	0.3644	1
Onchocerca volvulus		0.0231	0.3644	0.3911
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0231	0.3644	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Echinococcus granulosus	allatostatin A receptor	0.0231	0.3644	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0231	0.3644	1
Echinococcus granulosus	nmda type glutamate receptor	0.0026	0.0088	0.0242
Echinococcus granulosus	rhodopsin orphan GPCR	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Brugia malayi	Serotonin receptor	0.0231	0.3644	0.3644
Echinococcus multilocularis	g protein coupled receptor	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Schistosoma mansoni	growth hormone secretagogue receptor	0.0231	0.3644	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0231	0.3644	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0037	0.0267	0.0267
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0231	0.3644	0.3911
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0231	0.3644	1
Schistosoma mansoni	hypothetical protein	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Brugia malayi	hypothetical protein	0.0231	0.3644	0.3644
Echinococcus granulosus	serotonin receptor	0.0231	0.3644	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0231	0.3644	1
Brugia malayi	ORL1-like opioid receptor	0.0231	0.3644	0.3644
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Echinococcus granulosus	orexin receptor type 2	0.0231	0.3644	1
Brugia malayi	hypothetical protein	0.0231	0.3644	0.3644
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0231	0.3644	0.3644
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0231	0.3644	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0231	0.3644	1
Schistosoma mansoni	amine GPCR	0.0231	0.3644	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Echinococcus granulosus	g protein coupled receptor	0.0231	0.3644	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0231	0.3644	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0231	0.3644	1
Onchocerca volvulus		0.0231	0.3644	0.3911
Schistosoma mansoni	histamine h1 receptor	0.0231	0.3644	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0231	0.3644	1
Onchocerca volvulus		0.0231	0.3644	0.3911
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0267	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0231	0.3644	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Brugia malayi	hypothetical protein	0.0231	0.3644	0.3644
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0037	0.0267	0.0733
Echinococcus granulosus	tm gpcr rhodopsin	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Echinococcus granulosus	tm gpcr rhodopsin	0.0231	0.3644	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0231	0.3644	1
Onchocerca volvulus		0.0231	0.3644	0.3911
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0231	0.3644	0.3644
Echinococcus multilocularis	neuropeptide s receptor	0.0231	0.3644	1
Echinococcus multilocularis	fmrfamide receptor	0.0231	0.3644	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0231	0.3644	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0231	0.3644	1
Brugia malayi	sulfakinin receptor protein	0.0231	0.3644	0.3644
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Brugia malayi	hypothetical protein	0.0231	0.3644	0.3644
Brugia malayi	G-protein coupled receptor	0.0231	0.3644	0.3644
Schistosoma mansoni	amine GPCR	0.0231	0.3644	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0231	0.3644	1
Loa Loa (eye worm)	TYRA-2 protein	0.0231	0.3644	0.3644
Echinococcus granulosus	neuropeptides capa receptor	0.0231	0.3644	1
Onchocerca volvulus		0.0231	0.3644	0.3911
Echinococcus multilocularis	geminin	0.0175	0.2675	0.7341
Echinococcus granulosus	biogenic amine 5HT receptor	0.0231	0.3644	1
Schistosoma mansoni	myosin xvIII	0.0231	0.3644	1
Schistosoma mansoni	tyrosine kinase	0.0025	0.0058	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Echinococcus granulosus	rhodopsin orphan GPCR	0.0231	0.3644	1
Echinococcus multilocularis	neuropeptide receptor	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Brugia malayi	larval opioid receptor	0.0231	0.3644	0.3644
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0231	0.3644	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0267	0.0267
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0231	0.3644	0.3644
Loa Loa (eye worm)	neuropeptide F receptor	0.0231	0.3644	0.3644
Onchocerca volvulus		0.0545	0.9096	0.9763
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0231	0.3644	1
Schistosoma mansoni	adenoreceptor	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0231	0.3644	1
Echinococcus granulosus	neuropeptide Y receptor	0.0231	0.3644	1
Echinococcus multilocularis	neuroglian	0.0046	0.043	0.118
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Onchocerca volvulus		0.0231	0.3644	0.3911
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Echinococcus multilocularis	allatostatin A receptor	0.0231	0.3644	1
Brugia malayi	hypothetical protein	0.0231	0.3644	0.3644
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Brugia malayi	hypothetical protein	0.0231	0.3644	0.3644
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0231	0.3644	0.3644
Onchocerca volvulus		0.0231	0.3644	0.3911
Schistosoma mansoni	nephrin	0.0046	0.043	0.118
Echinococcus granulosus	neuropeptide receptor A26	0.0231	0.3644	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0231	0.3644	1
Onchocerca volvulus		0.0231	0.3644	0.3911
Schistosoma mansoni	amine GPCR	0.0231	0.3644	1
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0026	0.0088	0.0242
Schistosoma mansoni	neuropeptide receptor	0.0231	0.3644	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0231	0.3644	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0475	0.0475
Schistosoma mansoni	neuropeptide receptor	0.0231	0.3644	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0231	0.3644	1
Schistosoma mansoni	hypothetical protein	0.0231	0.3644	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0231	0.3644	1
Schistosoma mansoni	biogenic amine receptor	0.0231	0.3644	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0231	0.3644	1
Schistosoma mansoni	biogenic amine receptor	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0267	0.0267
Echinococcus granulosus	roundabout 2	0.0058	0.0638	0.1751
Brugia malayi	G-protein coupled receptor	0.0231	0.3644	0.3644
Brugia malayi	AKH receptor	0.0231	0.3644	0.3644
Brugia malayi	hypothetical protein	0.0231	0.3644	0.3644
Brugia malayi	follicle stimulating hormone receptor	0.0231	0.3644	0.3644
Echinococcus multilocularis	orexin receptor type 2	0.0231	0.3644	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0231	0.3644	1
Echinococcus granulosus	fmrfamide receptor	0.0231	0.3644	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Loa Loa (eye worm)	G-protein coupled receptor	0.0231	0.3644	0.3644
Echinococcus granulosus	G protein coupled receptor 139	0.0231	0.3644	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0231	0.3644	1
Echinococcus multilocularis	fmrfamide receptor	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Onchocerca volvulus		0.0231	0.3644	0.3911
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0049	0.0475	0.1304
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0231	0.3644	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0231	0.3644	0.3644
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0231	0.3644	1
Echinococcus granulosus	geminin	0.0175	0.2675	0.7341
Schistosoma mansoni	opsin-like receptor	0.0231	0.3644	1
Echinococcus granulosus	neuropeptide receptor	0.0231	0.3644	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0231	0.3644	0.3644
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0231	0.3644	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0231	0.3644	1
Brugia malayi	neuropeptide F receptor	0.0231	0.3644	0.3644
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Echinococcus multilocularis	g-protein coupled receptor	0.0231	0.3644	1
Schistosoma mansoni	opsin-like receptor	0.0231	0.3644	1
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3644	0.3644
Toxoplasma gondii	1,3-beta-glucan synthase component protein	0.0256	0.4077	0.5
Onchocerca volvulus		0.0231	0.3644	0.3911
Brugia malayi	Serotonin receptor	0.0231	0.3644	0.3644
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0231	0.3644	1
Echinococcus multilocularis	g protein coupled receptor	0.0231	0.3644	1
Brugia malayi	G protein-coupled receptor	0.0231	0.3644	0.3644
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0231	0.3644	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0231	0.3644	0.3644
Echinococcus multilocularis	neuropeptide Y receptor	0.0231	0.3644	1
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0037	0.0267	0.0733
Brugia malayi	hypothetical protein	0.0231	0.3644	0.3644
Schistosoma mansoni	opsin-like receptor	0.0231	0.3644	1
Echinococcus granulosus	defective proboscis extension response	0.0037	0.0267	0.0733
Echinococcus multilocularis	Immunoglobulin	0.0037	0.0267	0.0733
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0231	0.3644	1
Echinococcus multilocularis	roundabout 2	0.0058	0.0638	0.1751
Schistosoma mansoni	hypothetical protein	0.0231	0.3644	1
Brugia malayi	Melatonin receptor type 1A	0.0231	0.3644	0.3644
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0231	0.3644	1
Brugia malayi	Dopamine receptor	0.0231	0.3644	0.3644

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.9 ug ml-1	Inhibition of Candida albicans BWP17 1,3-beta-D-glucan synthase	ChEMBL.	21316223
IC50 (binding)	= 0.9 ug ml-1	Inhibition of Candida albicans BWP17 1,3-beta-glucan synthase	ChEMBL.	21489787
MIC100 (functional)	= 3.1 ug ml-1	Antifungal activity against Candida albicans C693 by broth dilution method	ChEMBL.	21316223
MIC100 (functional)	= 3.13 ug ml-1	Antifungal activity against Candida albicans C693	ChEMBL.	21489787

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1684744

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 1503703