Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.1271 | 1 |
Plasmodium falciparum | sortilin | 0.0738 | 0.9226 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.004 | 0.0276 | 0.0427 |
Echinococcus granulosus | sortilin | 0.0738 | 0.9226 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0033 | 0.0256 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0069 | 0.0645 | 0.0699 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0069 | 0.0645 | 0.0998 |
Plasmodium vivax | sortilin, putative | 0.0738 | 0.9226 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0082 | 0.0816 | 0.6424 |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.2523 | 0.3903 |
Loa Loa (eye worm) | glutamate receptor | 0.0032 | 0.0177 | 0.1393 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0021 | 0.0033 | 0.0256 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.004 | 0.0276 | 0.2173 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0101 | 0.106 | 0.106 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.1271 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0074 | 0.0717 | 0.5644 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.106 | 0.834 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.2082 | 0.322 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.1271 | 1 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0021 | 0.0033 | 0.0256 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0101 | 0.106 | 0.1149 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0093 | 0.0961 | 0.1486 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0082 | 0.0816 | 0.6424 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0021 | 0.0033 | 0.0256 |
Echinococcus multilocularis | sortilin | 0.0738 | 0.9226 | 0.9226 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0069 | 0.0645 | 0.0645 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.2082 | 0.322 |
Toxoplasma gondii | sortilin, putative | 0.0738 | 0.9226 | 1 |
Schistosoma mansoni | sortilin | 0.0522 | 0.6465 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of protein farnesyltransferase from human EC17 cells using [3H]FPP and GTP-H-Ras | ChEMBL. | 21306898 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.