Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 1068 aa | 927 aa | 29.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0081 | 0.274 | 0.0303 |
Plasmodium vivax | tubulin beta chain, putative | 0.0081 | 0.274 | 0.5 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0081 | 0.274 | 0.0303 |
Giardia lamblia | Beta tubulin | 0.0081 | 0.274 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0118 | 0.4652 | 1 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Echinococcus granulosus | beta tubulin | 0.0081 | 0.274 | 0.0303 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.004 | 0.0611 | 0.0426 |
Echinococcus multilocularis | beta tubulin | 0.0081 | 0.274 | 0.0303 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0104 | 0.3928 | 0.8209 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0052 | 0.1273 | 0.1637 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0081 | 0.274 | 0.0303 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0081 | 0.274 | 0.0303 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0081 | 0.274 | 0.5268 |
Schistosoma mansoni | tubulin subunit beta | 0.0081 | 0.274 | 0.2267 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.2513 | 0.2499 |
Entamoeba histolytica | tubulin family protein | 0.0081 | 0.274 | 0.5268 |
Trypanosoma brucei | beta tubulin | 0.0081 | 0.274 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0081 | 0.274 | 0.0303 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0081 | 0.274 | 0.0303 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0081 | 0.274 | 0.5 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0081 | 0.274 | 0.2772 |
Echinococcus granulosus | beta tubulin | 0.0081 | 0.274 | 0.0303 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0118 | 0.4652 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0077 | 0.2513 | 0.4706 |
Giardia lamblia | Beta tubulin | 0.0081 | 0.274 | 1 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0081 | 0.274 | 0.0303 |
Brugia malayi | Tubulin beta-1 chain | 0.0081 | 0.274 | 0.5268 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0057 | 0.151 | 0.5512 |
Echinococcus multilocularis | tubulin subunit beta | 0.0081 | 0.274 | 0.0303 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0081 | 0.274 | 0.2772 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0118 | 0.4652 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0081 | 0.274 | 0.2772 |
Trypanosoma brucei | beta tubulin | 0.0081 | 0.274 | 1 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0115 | 0.4472 | 0.9555 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0081 | 0.274 | 0.5268 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0081 | 0.274 | 0.0303 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0081 | 0.274 | 0.5268 |
Trypanosoma brucei | beta tubulin | 0.0081 | 0.274 | 1 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0118 | 0.4652 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0118 | 0.4652 | 1 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0118 | 0.4652 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0081 | 0.274 | 0.2267 |
Brugia malayi | beta-tubulin, identical | 0.0081 | 0.274 | 0.5268 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0094 | 0.3412 | 0.6931 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0719 | 0.0346 |
Schistosoma mansoni | tubulin subunit beta | 0.0081 | 0.274 | 0.2267 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0081 | 0.274 | 0.0303 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0081 | 0.274 | 0.0303 |
Plasmodium falciparum | tubulin beta chain | 0.0081 | 0.274 | 0.5 |
Echinococcus multilocularis | beta tubulin | 0.0081 | 0.274 | 0.0303 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0081 | 0.275 | 0.5294 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0081 | 0.274 | 0.0303 |
Loa Loa (eye worm) | tubulin beta chain | 0.0081 | 0.274 | 0.2772 |
Schistosoma mansoni | tubulin subunit beta | 0.0081 | 0.274 | 0.2267 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0081 | 0.274 | 0.2267 |
Toxoplasma gondii | beta-tubulin, putative | 0.0081 | 0.274 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0081 | 0.274 | 0.0303 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0198 | 0.876 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0081 | 0.274 | 0.2772 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0081 | 0.274 | 0.2772 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0081 | 0.274 | 0.5268 |
Schistosoma mansoni | tubulin subunit beta | 0.0081 | 0.274 | 0.2267 |
Echinococcus granulosus | tubulin subunit beta | 0.0081 | 0.274 | 0.0303 |
Entamoeba histolytica | tubulin family protein | 0.0081 | 0.274 | 0.5268 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0081 | 0.275 | 0.5294 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Trypanosoma cruzi | beta tubulin, putative | 0.0081 | 0.274 | 0.547 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0081 | 0.274 | 0.2772 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0081 | 0.274 | 0.0303 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0094 | 0.3412 | 0.6931 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0081 | 0.274 | 0.0303 |
Giardia lamblia | Beta tubulin | 0.0081 | 0.274 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0081 | 0.274 | 0.5268 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0081 | 0.274 | 0.5268 |
Leishmania major | beta tubulin | 0.0081 | 0.274 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0081 | 0.274 | 1 |
Toxoplasma gondii | beta tubulin | 0.0081 | 0.274 | 0.5 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0118 | 0.4652 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.11 uM | Inhibition of PI3Kalpha-mediated Akt phosphorylation at Ser473 in human A2780 cells after 1 hr | ChEMBL. | 24900252 |
EC50 (functional) | = 0.14 uM | Antiproliferative activity against human A2780 cells | ChEMBL. | 24900252 |
IC50 (binding) | = 0.007 uM | Inhibition of PI3Kalpha after 15 mins | ChEMBL. | 24900252 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24900252 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.