Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0481 | 0.1142 | 0.0733 |
Echinococcus multilocularis | ectonucleotide | 0.0405 | 0.0866 | 0.0444 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.1356 | 0.4338 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0481 | 0.1142 | 0.0733 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0481 | 0.1142 | 0.0733 |
Onchocerca volvulus | 0.1038 | 0.3176 | 0.7321 | |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.1356 | 0.4338 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.1142 | 0.0735 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0481 | 0.1142 | 0.0733 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.1038 | 0.3176 | 0.2863 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0938 | 0.2812 | 0.5 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0418 | 0.0913 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0481 | 0.1142 | 0.0733 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.1356 | 0.4338 | 1 |
Brugia malayi | Protein-tyrosine phosphatase | 0.0298 | 0.0476 | 0.0037 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0481 | 0.1142 | 0.0733 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0418 | 0.0913 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0481 | 0.1142 | 0.0733 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0481 | 0.1142 | 0.0733 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0481 | 0.1142 | 0.0733 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0481 | 0.1142 | 0.0733 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0405 | 0.0866 | 0.0444 |
Leishmania major | hypothetical protein, conserved | 0.0418 | 0.0913 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.1142 | 0.0735 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0481 | 0.1142 | 0.0733 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0481 | 0.1142 | 0.0733 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.1356 | 0.4338 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0481 | 0.1142 | 0.0733 |
Onchocerca volvulus | 0.1356 | 0.4338 | 1 | |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0481 | 0.1142 | 0.0733 |
Onchocerca volvulus | 0.0481 | 0.1142 | 0.2632 | |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0481 | 0.1142 | 0.0733 |
Echinococcus granulosus | ectonucleotide | 0.0405 | 0.0866 | 0.0444 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.1356 | 0.4338 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.1142 | 0.0735 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0405 | 0.0866 | 0.0444 |
Loa Loa (eye worm) | hypothetical protein | 0.0405 | 0.0866 | 0.0447 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0481 | 0.1142 | 0.0733 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.1356 | 0.4338 | 0.5 |
Onchocerca volvulus | 0.0481 | 0.1142 | 0.2632 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0418 | 0.0913 | 1 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.1038 | 0.3176 | 0.2861 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.1356 | 0.4338 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1038 | 0.3176 | 0.2861 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0289 | 0.0441 | 0.5 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.1356 | 0.4338 | 0.4077 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.1356 | 0.4338 | 1 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.1356 | 0.4338 | 0.5 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.1356 | 0.4338 | 0.4079 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.1356 | 0.4338 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IP (functional) | = 332 nM | Antagonist activity at Cav3.3 alpha1i expressed in HEK293 cells by depolarized FLIPR assay | ChEMBL. | 21316226 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.