Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 4 | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, metabotropic 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Golgi-associated plant pathogenesis-related protein 1 homolog | Metabotropic glutamate receptor 4 | 912 aa | 826 aa | 34.7 % |
Onchocerca volvulus | Cell death abnormality protein 8 homolog | Metabotropic glutamate receptor 4 | 912 aa | 874 aa | 39.1 % |
Schistosoma mansoni | metabotropic glutamate receptor | Metabotropic glutamate receptor 4 | 912 aa | 903 aa | 25.6 % |
Loa Loa (eye worm) | hypothetical protein | Metabotropic glutamate receptor 4 | 912 aa | 881 aa | 20.9 % |
Onchocerca volvulus | Metabotropic glutamate receptor 4 | 912 aa | 841 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0076 | 0.1639 | 0.1639 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0122 | 0.6127 | 0.6127 |
Brugia malayi | nuclear receptor NHR-88 | 0.0076 | 0.1639 | 0.1639 |
Brugia malayi | nuclear receptor RXR | 0.0076 | 0.1639 | 0.1639 |
Brugia malayi | hypothetical protein | 0.0086 | 0.2535 | 0.2535 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.015 | 0.8889 | 0.8671 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0086 | 0.2535 | 0.2535 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.015 | 0.8889 | 0.8671 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2535 | 0.1071 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0086 | 0.2535 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2535 | 0.1071 |
Schistosoma mansoni | nuclear hormone receptor | 0.0076 | 0.1639 | 0.1639 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0076 | 0.1639 | 0.1639 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0076 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2535 | 0.1071 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0076 | 0.1639 | 0.1639 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0102 | 0.4187 | 0.3047 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0076 | 0.1639 | 0.1639 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0086 | 0.2535 | 0.2535 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0076 | 0.1639 | 0.1639 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0076 | 0.1639 | 0.1639 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2535 | 0.1071 |
Brugia malayi | nuclear receptor RXR | 0.0086 | 0.2535 | 0.2535 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0076 | 0.1639 | 0.1639 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0086 | 0.2535 | 0.2535 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0139 | 0.7765 | 0.7765 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2535 | 0.1071 |
Brugia malayi | tailless protein | 0.0076 | 0.1639 | 0.1639 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0076 | 0.1639 | 0.1639 |
Brugia malayi | hypothetical protein | 0.0076 | 0.1639 | 0.1639 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0102 | 0.4187 | 0.4187 |
Schistosoma mansoni | nuclear hormone receptor | 0.0076 | 0.1639 | 0.1639 |
Brugia malayi | nuclear receptor NHR-67 | 0.0076 | 0.1639 | 0.1639 |
Brugia malayi | hypothetical protein | 0.0086 | 0.2535 | 0.2535 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.8889 | 0.8671 |
Loa Loa (eye worm) | glutamate receptor | 0.0122 | 0.6127 | 0.5368 |
Brugia malayi | ecdysone receptor | 0.0076 | 0.1639 | 0.1639 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0102 | 0.4187 | 0.3047 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0086 | 0.2535 | 0.1071 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0086 | 0.2535 | 0.1071 |
Schistosoma mansoni | nuclear receptor | 0.0076 | 0.1639 | 0.1639 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0076 | 0.1639 | 0.1639 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0111 | 0.5003 | 0.5003 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0086 | 0.2535 | 0.2535 |
Brugia malayi | conserved hypotetical protein | 0.0076 | 0.1639 | 0.1639 |
Schistosoma mansoni | nuclear receptor | 0.0076 | 0.1639 | 0.1639 |
Brugia malayi | nuclear hormone receptor | 0.0076 | 0.1639 | 0.1639 |
Schistosoma mansoni | zinc finger protein | 0.0076 | 0.1639 | 0.1639 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 77.6 % | Positive allosteric modulation of human mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilization relative to PHCCC | ChEMBL. | 21247167 |
Activity (binding) | = 133.9 % | Positive allosteric modulation of rat mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilization relative to PHCCC | ChEMBL. | 21247167 |
EC50 (binding) | = 377 nM | Positive allosteric modulation of rat mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilization | ChEMBL. | 21247167 |
EC50 (binding) | = 627 nM | Positive allosteric modulation of human mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilization | ChEMBL. | 21247167 |
Inhibition (binding) | Inhibition of human CYP3A4 | ChEMBL. | 21247167 | |
Inhibition (binding) | Inhibition of human CYP1A2 | ChEMBL. | 21247167 | |
Inhibition (binding) | Inhibition of human CYP2D6 | ChEMBL. | 21247167 | |
Inhibition (binding) | Inhibition of human CYP2C9 | ChEMBL. | 21247167 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.