TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 545.535 | Formula: C27H30F7N3O
H donors: 0 H acceptors: 1 LogP: 6.12 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: Fc1ccc(c(c1)C)[C@H]1C[C@H](CCN1C(=O)N([C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)C)N1CCC1
InChi: 1S/C27H30F7N3O/c1-16-11-21(28)5-6-23(16)24-15-22(36-8-4-9-36)7-10-37(24)25(38)35(3)17(2)18-12-19(26(29,30)31)14-20(13-18)27(32,33)34/h5-6,11-14,17,22,24H,4,7-10,15H2,1-3H3/t17-,22+,24-/m1/s1
InChiKey: DEVSGOOMIYSMNC-OUPRXKBMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tachykinin receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K04224 tachykinin receptor 3, putative	Get druggable targets OG5_137770	All targets in OG5_137770

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0014	0.1054	0.1054
Trichomonas vaginalis	TK family protein kinase	0.0014	0.1054	0.1943
Loa Loa (eye worm)	TK/EPH protein kinase	0.0014	0.1054	0.1054
Echinococcus granulosus	tyrosine protein kinase pr2	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Brugia malayi	RhoGAP domain containing protein	0.005	0.7488	0.7488
Brugia malayi	Furin-like cysteine rich region family protein	0.0014	0.1054	0.1054
Brugia malayi	Tensin	0.005	0.7488	0.7488
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0014	0.1054	0.5
Loa Loa (eye worm)	hypothetical protein	0.0014	0.1054	0.1054
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0014	0.1054	0.5
Loa Loa (eye worm)	TK/DDR protein kinase	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0014	0.1054	0.5
Schistosoma mansoni	serine/threonine RGC	0.0014	0.1054	0.1054
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0014	0.1054	0.1054
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.005	0.7488	0.7488
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.6587	0.6587
Schistosoma mansoni	adapter molecule crk	0.005	0.7488	0.7488
Echinococcus multilocularis	epidermal growth factor receptor	0.0014	0.1054	0.1054
Loa Loa (eye worm)	hypothetical protein	0.005	0.7488	0.7488
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0014	0.1054	0.1054
Schistosoma mansoni	protein kinase	0.0014	0.1054	0.1054
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.005	0.7488	0.7488
Echinococcus multilocularis		0.005	0.7488	0.7488
Loa Loa (eye worm)	TK protein kinase	0.0014	0.1054	0.1054
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Schistosoma mansoni	serine/threonine protein kinase	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0014	0.1054	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.1054	0.1943
Loa Loa (eye worm)	hypothetical protein	0.005	0.7488	0.7488
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0014	0.1054	0.1054
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.7488	0.7488
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0012	0.0677	0.0677
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0014	0.1054	0.1054
Echinococcus granulosus	epidermal growth factor receptor	0.0014	0.1054	0.1054
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0014	0.1054	0.1054
Echinococcus multilocularis	tyrosine protein kinase	0.0014	0.1054	0.1054
Schistosoma mansoni	protein kinase	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Loa Loa (eye worm)	hypothetical protein	0.005	0.7488	0.7488
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.005	0.7488	0.7488
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0041	0.591	0.591
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.005	0.7488	0.7488
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0014	0.1054	0.1054
Onchocerca volvulus		0.005	0.7488	0.7192
Echinococcus multilocularis	heat shock protein 70	0.0014	0.1054	0.1054
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0014	0.1054	0.1054
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0014	0.1054	0.5
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0012	0.0677	0.0677
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0014	0.1054	0.1054
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Schistosoma mansoni	GTPase activating protein	0.005	0.7488	0.7488
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Schistosoma mansoni	protein kinase	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0014	0.1054	0.1054
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0014	0.1054	0.1054
Loa Loa (eye worm)	TK/FER protein kinase	0.0014	0.1054	0.1054
Loa Loa (eye worm)	TK/INSR protein kinase	0.0014	0.1054	0.1054
Echinococcus multilocularis	tensin	0.005	0.7488	0.7488
Schistosoma mansoni	ephrin receptor	0.0014	0.1054	0.1054
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0014	0.1054	0.5
Echinococcus granulosus	activin receptor type	0.0014	0.1054	0.1054
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0014	0.1054	0.1054
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Loa Loa (eye worm)	TK/Met protein kinase	0.0014	0.1054	0.1054
Brugia malayi	C-terminal src kinase protein 1	0.0014	0.1054	0.1054
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.1054	0.1943
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Schistosoma mansoni	suppressor of cytokine signaling	0.005	0.7488	0.7488
Echinococcus multilocularis	tensin	0.005	0.7488	0.7488
Schistosoma mansoni	tensin	0.005	0.7488	0.7488
Loa Loa (eye worm)	TK protein kinase	0.0014	0.1054	0.1054
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0014	0.1054	0.1054
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0014	0.1054	0.1054
Loa Loa (eye worm)	hypothetical protein	0.005	0.7488	0.7488
Trichomonas vaginalis	STE family protein kinase	0.0014	0.1054	0.1943
Schistosoma mansoni	tensin	0.005	0.7488	0.7488
Schistosoma mansoni	tensin-related	0.005	0.7488	0.7488
Schistosoma mansoni	voltage-gated potassium channel	0.0012	0.0677	0.0677
Loa Loa (eye worm)	serine/threonine protein kinase	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0014	0.1054	0.1054
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Echinococcus granulosus	suppressor of cytokine signaling 6	0.005	0.7488	0.7488
Echinococcus multilocularis	SH2 domain containing protein 7	0.005	0.7488	0.7488
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Loa Loa (eye worm)	hypothetical protein	0.005	0.7488	0.7488
Onchocerca volvulus		0.005	0.7488	0.7192
Loa Loa (eye worm)	TK protein kinase	0.0014	0.1054	0.1054
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.005	0.7488	0.7488
Trichomonas vaginalis	CAMK family protein kinase	0.0014	0.1054	0.1943
Leishmania major	protein kinase, putative	0.0014	0.1054	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Brugia malayi	SH2 domain containing protein	0.005	0.7488	0.7488
Schistosoma mansoni	hypothetical protein	0.005	0.7488	0.7488
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Schistosoma mansoni	protein kinase	0.0014	0.1054	0.1054
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.005	0.7488	0.7488
Schistosoma mansoni	protein kinase	0.0014	0.1054	0.1054
Echinococcus granulosus	integrin linked protein kinase	0.0014	0.1054	0.1054
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Loa Loa (eye worm)	hypothetical protein	0.0014	0.1054	0.1054
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Toxoplasma gondii	STE kinase	0.0014	0.1054	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0014	0.1054	0.1054
Schistosoma mansoni	protein kinase	0.0014	0.1054	0.1054
Brugia malayi	STAT protein, DNA binding domain containing protein	0.005	0.7488	0.7488
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0014	0.1054	0.1943
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Plasmodium falciparum	tyrosine kinase-like protein	0.0014	0.1054	0.5
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.005	0.7488	0.7488
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.005	0.7488	0.7488
Brugia malayi	hypothetical protein	0.0014	0.1054	0.1054
Echinococcus granulosus	tyrosine protein kinase csk	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Schistosoma mansoni	growth factor receptor-bound protein	0.005	0.7488	0.7488
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Brugia malayi	ephrin receptor 1 precursor	0.0014	0.1054	0.1054
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.1054	0.1943
Brugia malayi	SH2 domain containing protein	0.005	0.7488	0.7488
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0014	0.1054	0.1054
Giardia lamblia	Kinase	0.0014	0.1054	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0014	0.1054	0.1054
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0038	0.5425	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0014	0.1054	0.1054
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0014	0.1054	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0014	0.1054	0.1054
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.005	0.7488	0.7192
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.7488	0.7488
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Schistosoma mansoni	tyrosine protein kinase	0.0014	0.1054	0.1054
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.005	0.7488	0.7488
Loa Loa (eye worm)	STAT protein	0.005	0.7488	0.7488
Echinococcus multilocularis	tyrosine kinase	0.0014	0.1054	0.1054
Brugia malayi	Receptor family ligand binding region containing protein	0.0014	0.1054	0.1054
Echinococcus multilocularis	activated cdc42 kinase 1	0.0014	0.1054	0.1054
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Brugia malayi	hypothetical protein	0.0014	0.1054	0.1054
Echinococcus granulosus	receptor type guanylyl cyclase	0.0014	0.1054	0.1054
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0014	0.1054	0.1054
Echinococcus multilocularis	protein kinase	0.0014	0.1054	0.1054
Toxoplasma gondii	protein kinase domain-containing protein	0.0014	0.1054	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Echinococcus multilocularis	integrin linked protein kinase	0.0014	0.1054	0.1054
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0014	0.1054	0.1054
Brugia malayi	Sex muscle abnormal protein 5	0.005	0.7488	0.7488
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0014	0.1054	0.1054
Echinococcus granulosus	signal transduction protein lnk realted	0.005	0.7488	0.7488
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0012	0.0677	0.0677
Loa Loa (eye worm)	hypothetical protein	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0014	0.1054	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0014	0.1054	0.1054
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Echinococcus granulosus	tyrosine protein kinase	0.0014	0.1054	0.1054
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0014	0.1054	0.5
Brugia malayi	SH2 domain containing protein	0.005	0.7488	0.7488
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0014	0.1054	0.1054
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Loa Loa (eye worm)	TK/FER protein kinase	0.0014	0.1054	0.1054
Brugia malayi	integrin-linked kinase	0.0014	0.1054	0.1054
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Echinococcus granulosus	SH2 domain containing protein 7	0.005	0.7488	0.7488
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Echinococcus multilocularis	tyrosine protein kinase csk	0.0014	0.1054	0.1054
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.005	0.7488	0.7488
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Echinococcus granulosus	expressed conserved protein	0.005	0.7488	0.7488
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0014	0.1054	0.1054
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.005	0.7488	0.7488
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.005	0.7488	0.7488
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.005	0.7488	0.7192
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0014	0.1054	0.1054
Loa Loa (eye worm)	TK protein kinase	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Loa Loa (eye worm)	hypothetical protein	0.005	0.7488	0.7488
Echinococcus granulosus	tyrosine protein kinase csk	0.0014	0.1054	0.1054
Giardia lamblia	Protein 21.1	0.0014	0.1054	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.005	0.7488	0.7488
Loa Loa (eye worm)	TK/FER protein kinase	0.0014	0.1054	0.1054
Loa Loa (eye worm)	SH2 domain-containing protein	0.005	0.7488	0.7488
Trypanosoma brucei	Pseudokinase, putative	0.0014	0.1054	0.5
Echinococcus granulosus	N chimaerin	0.005	0.7488	0.7488
Schistosoma mansoni	growth factor receptor-bound protein	0.005	0.7488	0.7488
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0014	0.1054	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.7488	0.7488
Schistosoma mansoni	vav2	0.005	0.7488	0.7488
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0014	0.1054	0.1054
Leishmania major	hypothetical protein, conserved	0.0014	0.1054	0.5
Loa Loa (eye worm)	TK/RYK protein kinase	0.0014	0.1054	0.1054
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0014	0.1054	0.1943
Loa Loa (eye worm)	hypothetical protein	0.0014	0.1054	0.1054
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0014	0.1054	0.1054
Echinococcus multilocularis	protein tyrosine kinase	0.0014	0.1054	0.1054
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Giardia lamblia	Kinase, NEK	0.0014	0.1054	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0012	0.0677	0.0677
Entamoeba histolytica	protein kinase, putative	0.005	0.7488	0.7192
Loa Loa (eye worm)	TK protein kinase	0.0014	0.1054	0.1054
Schistosoma mansoni	ephrin receptor	0.0014	0.1054	0.1054
Loa Loa (eye worm)	hypothetical protein	0.005	0.7488	0.7488
Loa Loa (eye worm)	hypothetical protein	0.005	0.7488	0.7488
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0014	0.1054	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Echinococcus granulosus	SH2 motif	0.005	0.7488	0.7488
Echinococcus multilocularis	growth factor receptor bound protein 2	0.005	0.7488	0.7488
Echinococcus granulosus	suppressor of cytokine signaling 7	0.005	0.7488	0.7488
Echinococcus multilocularis	tyrosine protein kinase csk	0.0014	0.1054	0.1054
Loa Loa (eye worm)	TK protein kinase	0.0014	0.1054	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0014	0.1054	0.1054
Trypanosoma brucei	protein kinase, putative	0.0014	0.1054	0.5
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0014	0.1054	0.1054
Schistosoma mansoni	hypothetical protein	0.0014	0.1054	0.1054
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.005	0.7488	0.7488
Plasmodium falciparum	protein kinase, putative	0.0014	0.1054	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.7488	0.7488
Echinococcus granulosus	tensin	0.005	0.7488	0.7488
Loa Loa (eye worm)	TK/FER protein kinase	0.0014	0.1054	0.1054
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0014	0.1054	0.1943
Loa Loa (eye worm)	TK/CSK protein kinase	0.0014	0.1054	0.1054
Loa Loa (eye worm)	TK/FER protein kinase	0.0014	0.1054	0.1054
Brugia malayi	Variant SH3 domain containing protein	0.005	0.7488	0.7488
Echinococcus granulosus	SHC transforming protein 3	0.005	0.7488	0.7488
Echinococcus granulosus	activated cdc42 kinase 1	0.0014	0.1054	0.1054
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0014	0.1054	0.1054
Loa Loa (eye worm)	TK/ROR protein kinase	0.0014	0.1054	0.1054
Echinococcus granulosus	tyrosine protein kinase HCK	0.0014	0.1054	0.1054
Toxoplasma gondii	protein kinase	0.0014	0.1054	0.5
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0014	0.1054	0.1054
Loa Loa (eye worm)	TK/FER protein kinase	0.0014	0.1054	0.1054
Schistosoma mansoni	shc transforming protein	0.005	0.7488	0.7488
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Trichomonas vaginalis	protein kinase atn1, putative	0.0014	0.1054	0.1943
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0014	0.1054	0.1054
Loa Loa (eye worm)	SH2 domain-containing protein	0.005	0.7488	0.7488
Echinococcus granulosus	insulin receptor	0.0014	0.1054	0.1054
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0041	0.591	0.591
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Loa Loa (eye worm)	hypothetical protein	0.0036	0.4937	0.4937
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0014	0.1054	0.1054
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Schistosoma mansoni	signal transduction protein lnk-related	0.005	0.7488	0.7488
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0014	0.1054	0.1054
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0014	0.1054	0.1054
Loa Loa (eye worm)	hypothetical protein	0.005	0.7488	0.7488
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Loa Loa (eye worm)	hypothetical protein	0.005	0.7488	0.7488
Schistosoma mansoni	protein kinase	0.0014	0.1054	0.1054
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.005	0.7488	0.7488
Plasmodium falciparum	protein kinase, putative	0.0014	0.1054	0.5
Echinococcus multilocularis	signal transduction protein lnk realted	0.005	0.7488	0.7488
Schistosoma mansoni	serine/threonine protein kinase	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0014	0.1054	0.1943
Schistosoma mansoni	protein kinase	0.0014	0.1054	0.1054
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0014	0.1054	0.1054
Schistosoma mansoni	SH2A	0.005	0.7488	0.7488
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Schistosoma mansoni	tensin	0.005	0.7488	0.7488
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Plasmodium falciparum	protein kinase, putative	0.0014	0.1054	0.5
Schistosoma mansoni	protein kinase	0.0014	0.1054	0.1054
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0041	0.591	0.591
Loa Loa (eye worm)	hypothetical protein	0.005	0.7488	0.7488
Schistosoma mansoni	suppressor of cytokine signaling	0.005	0.7488	0.7488
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Echinococcus multilocularis	transfer RNA-Thr	0.0014	0.1054	0.1054
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.005	0.7488	0.7488
Giardia lamblia	Kinase, NEK	0.0014	0.1054	0.5
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.005	0.7488	0.7488
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Echinococcus multilocularis	tyrosine protein kinase csk	0.0014	0.1054	0.1054
Echinococcus granulosus	growth factor receptor bound protein 2	0.005	0.7488	0.7488
Onchocerca volvulus		0.005	0.7488	0.7192
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.005	0.7488	0.7488
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0014	0.1054	0.1054
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0014	0.1054	0.1054
Onchocerca volvulus		0.005	0.7488	0.7192
Schistosoma mansoni	hypothetical protein	0.005	0.7488	0.7488
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0014	0.1054	0.1054
Schistosoma mansoni	tensin-related	0.005	0.7488	0.7488
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0014	0.1054	0.1054
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0014	0.1054	0.1054
Echinococcus granulosus	activated cdc42 kinase 1	0.0014	0.1054	0.1054
Echinococcus multilocularis	SH2 motif	0.005	0.7488	0.7488
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Echinococcus multilocularis	protein kinase	0.0014	0.1054	0.1054
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.1054	0.1943
Echinococcus granulosus	tyrosine protein kinase csk	0.0014	0.1054	0.1054
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0014	0.1054	0.1054
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0014	0.1054	0.1054
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0014	0.1054	0.1054
Brugia malayi	Variant SH3 domain containing protein	0.005	0.7488	0.7488
Trypanosoma cruzi	protein kinase, putative	0.0014	0.1054	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.005	0.7488	0.7488
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0041	0.591	0.591
Onchocerca volvulus		0.005	0.7488	0.7192
Echinococcus multilocularis	FL cytokine receptor	0.0014	0.1054	0.1054
Brugia malayi	Raf kinase	0.0014	0.1054	0.1054
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0014	0.1054	0.1054
Echinococcus multilocularis	activin receptor type	0.0014	0.1054	0.1054
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.005	0.7488	0.7488
Schistosoma mansoni	protein kinase	0.0014	0.1054	0.1054
Echinococcus granulosus	protein tyrosine kinase	0.0014	0.1054	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0014	0.1054	0.1054
Echinococcus granulosus	raf serine:threonine protein kinase	0.0014	0.1054	0.1054
Loa Loa (eye worm)	TK protein kinase	0.0014	0.1054	0.1054
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Echinococcus multilocularis	SHC transforming protein 3	0.005	0.7488	0.7488
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Brugia malayi	Guanylyl cyclase protein 23	0.0014	0.1054	0.1054
Brugia malayi	SH2 domain containing protein	0.005	0.7488	0.7488
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0014	0.1054	0.1054
Echinococcus granulosus	epidermal growth factor receptor	0.0014	0.1054	0.1054
Echinococcus granulosus	tyrosine protein kinase Src42A	0.005	0.7488	0.7488
Leishmania major	protein kinase, putative	0.0014	0.1054	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.1054	0.1054
Loa Loa (eye worm)	hypothetical protein	0.005	0.7488	0.7488
Schistosoma mansoni	protein tyrosine kinase	0.0014	0.1054	0.1054
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0014	0.1054	0.1054
Plasmodium vivax	protein kinase, putative	0.0014	0.1054	0.5
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.005	0.7488	0.7488
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0014	0.1054	0.1054
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.1054	0.1943
Loa Loa (eye worm)	TK/ALK protein kinase	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0014	0.1054	0.1054
Echinococcus multilocularis	NCK adaptor protein	0.005	0.7488	0.7488
Brugia malayi	Tyrosine-protein kinase PR2	0.0014	0.1054	0.1054
Echinococcus granulosus	tyrosine kinase	0.0014	0.1054	0.1054
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0014	0.1054	0.1054
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.005	0.7488	0.7488
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Brugia malayi	tRNA modification GTPase TrmE family protein	0.005	0.7488	0.7488
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0014	0.1054	0.1054
Loa Loa (eye worm)	SH2 domain-containing protein	0.005	0.7488	0.7488
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0014	0.1054	0.1054
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.005	0.7488	0.7488
Brugia malayi	Variant SH3 domain containing protein	0.005	0.7488	0.7488
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Loa Loa (eye worm)	TK protein kinase	0.0014	0.1054	0.1054
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0014	0.1054	0.1054
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0038	0.5425	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0014	0.1054	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0677	0.0677
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Onchocerca volvulus		0.005	0.7488	0.7192
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.005	0.7488	0.7488
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.005	0.7488	0.7192
Echinococcus multilocularis	SH2 motif	0.005	0.7488	0.7488
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Schistosoma mansoni	serine/threonine protein kinase	0.0014	0.1054	0.1054
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.1054	0.1943
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0014	0.1054	0.1054
Echinococcus multilocularis	N chimaerin	0.005	0.7488	0.7488
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Echinococcus granulosus	natriuretic peptide receptor 1	0.0014	0.1054	0.1054
Brugia malayi	hypothetical protein	0.005	0.7488	0.7488
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Echinococcus multilocularis	voltage gated potassium channel	0.0012	0.0677	0.0677
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Echinococcus granulosus	protein kinase	0.0014	0.1054	0.1054
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0014	0.1054	0.1054
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0014	0.1054	0.1943
Echinococcus multilocularis	insulin receptor	0.0014	0.1054	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0014	0.1054	0.1054
Loa Loa (eye worm)	TK/ACK protein kinase	0.0014	0.1054	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.1054	0.1943
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Brugia malayi	Variant SH3 domain containing protein	0.005	0.7488	0.7488
Brugia malayi	SH2 domain containing protein	0.005	0.7488	0.7488
Brugia malayi	cytokine inducible SH2-containing protein 5	0.005	0.7488	0.7488
Entamoeba histolytica	SH2 domain containing protein	0.005	0.7488	0.7192
Echinococcus granulosus	SH2 domain containing adapter protein F	0.005	0.7488	0.7488
Schistosoma mansoni	protein kinase	0.0014	0.1054	0.1054
Echinococcus multilocularis	SH2 motif	0.005	0.7488	0.7488
Echinococcus granulosus	hypothetical protein	0.005	0.7488	0.7488
Schistosoma mansoni	tyrosine kinase	0.0014	0.1054	0.1054
Echinococcus granulosus	NCK adaptor protein	0.005	0.7488	0.7488
Trypanosoma cruzi	protein kinase, putative	0.0014	0.1054	0.5
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Schistosoma mansoni	nck2/grb4	0.005	0.7488	0.7488
Echinococcus granulosus	voltage gated potassium channel	0.0012	0.0677	0.0677
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0014	0.1054	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.7488	0.7488
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Plasmodium falciparum	tyrosine kinase-like protein	0.0014	0.1054	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.0014	0.1054	0.1054
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0014	0.1054	0.1054
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.6587	0.6587
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Echinococcus granulosus	kinase suppressor of Ras 1	0.0014	0.1054	0.1054
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.1054	0.1943
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0014	0.1054	0.1054
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0014	0.1054	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0014	0.1054	0.1054
Trichomonas vaginalis	TKL family protein kinase	0.0014	0.1054	0.1943
Brugia malayi	SH2 domain containing protein	0.005	0.7488	0.7488
Loa Loa (eye worm)	TK protein kinase	0.0014	0.1054	0.1054
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0014	0.1054	0.1054
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Echinococcus granulosus	SH2 motif	0.005	0.7488	0.7488
Brugia malayi	Protein kinase domain containing protein	0.0014	0.1054	0.1054
Brugia malayi	SH2 domain containing protein	0.005	0.7488	0.7488

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 9.75	Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL.	21229983

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1672048

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1506850