Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0482 | 0.057 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.285 | 0.4092 | 0.4092 |
Brugia malayi | Carboxylesterase family protein | 0.285 | 0.4092 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.285 | 0.4092 | 0.4092 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0482 | 0.057 | 0.1394 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.017 | 0.0108 | 0.0263 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0482 | 0.057 | 0.057 |
Brugia malayi | Carboxylesterase family protein | 0.0482 | 0.057 | 0.1394 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0482 | 0.057 | 0.057 |
Brugia malayi | hypothetical protein | 0.0482 | 0.057 | 0.1394 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.2383 | 0.3397 | 0.8301 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0482 | 0.057 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0482 | 0.057 | 0.1394 |
Onchocerca volvulus | 0.0482 | 0.057 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.285 | 0.4092 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0482 | 0.057 | 0.1394 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0482 | 0.057 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2383 | 0.3397 | 0.8301 |
Echinococcus multilocularis | neuroligin | 0.0482 | 0.057 | 0.057 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0482 | 0.057 | 0.057 |
Brugia malayi | Carboxylesterase family protein | 0.285 | 0.4092 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0482 | 0.057 | 0.1394 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.017 | 0.0108 | 0.0263 |
Onchocerca volvulus | 0.0482 | 0.057 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.285 | 0.4092 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0124 | 0.0039 | 0.0039 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.017 | 0.0108 | 0.1889 |
Echinococcus granulosus | carboxylesterase 5A | 0.285 | 0.4092 | 0.4092 |
Loa Loa (eye worm) | hypothetical protein | 0.0482 | 0.057 | 0.1394 |
Loa Loa (eye worm) | hypothetical protein | 0.0482 | 0.057 | 0.1394 |
Loa Loa (eye worm) | hypothetical protein | 0.094 | 0.1252 | 0.306 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.285 | 0.4092 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0482 | 0.057 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.017 | 0.0108 | 0.0263 |
Brugia malayi | Carboxylesterase family protein | 0.0482 | 0.057 | 0.1394 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.2383 | 0.3397 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0482 | 0.057 | 0.1394 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0482 | 0.057 | 0.1394 |
Loa Loa (eye worm) | hypothetical protein | 0.285 | 0.4092 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0482 | 0.057 | 0.1394 |
Loa Loa (eye worm) | hypothetical protein | 0.0482 | 0.057 | 0.1394 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0482 | 0.057 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0482 | 0.057 | 0.1394 |
Loa Loa (eye worm) | carboxylesterase | 0.0482 | 0.057 | 0.1394 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0482 | 0.057 | 0.057 |
Echinococcus granulosus | acetylcholinesterase | 0.285 | 0.4092 | 0.4092 |
Schistosoma mansoni | gliotactin | 0.0482 | 0.057 | 0.1394 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0124 | 0.0039 | 0.0095 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0482 | 0.057 | 0.057 |
Leishmania major | C-8 sterol isomerase-like protein | 0.2383 | 0.3397 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.285 | 0.4092 | 0.4092 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | carboxylesterase | 0.0482 | 0.057 | 0.1394 |
Echinococcus multilocularis | carboxylesterase 5A | 0.285 | 0.4092 | 0.4092 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0482 | 0.057 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0482 | 0.057 | 0.1394 |
Loa Loa (eye worm) | hypothetical protein | 0.0482 | 0.057 | 0.1394 |
Echinococcus granulosus | neuroligin | 0.0482 | 0.057 | 0.057 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.2383 | 0.3397 | 0.5 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0124 | 0.0039 | 0.0039 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0482 | 0.057 | 0.057 |
Onchocerca volvulus | 0.0482 | 0.057 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.285 | 0.4092 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0482 | 0.057 | 0.1394 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.017 | 0.0108 | 0.0108 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0482 | 0.057 | 0.1394 |
Onchocerca volvulus | 0.0482 | 0.057 | 1 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0482 | 0.057 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (binding) | < 50 /M/s | Ratio of dissociation of enzyme-inhibitor-substrate complex to Ki for porcine pancreatic elastase | ChEMBL. | 21315589 |
Ratio (binding) | = 201 /M/s | Ratio of dissociation of enzyme-inhibitor-substrate complex to Ki for human neutrophil elastase | ChEMBL. | 21315589 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.