Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0206 | 0.0965 | 1 | |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0559 | 0.3035 | 0.3298 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1222 | 0.6913 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.1222 | 0.6913 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1222 | 0.6913 | 0.6521 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1222 | 0.6913 | 0.7647 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1426 | 0.8106 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1426 | 0.8106 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1624 | 0.9263 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1426 | 0.8106 | 0.8751 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.0071 | 0.0177 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0979 | 0.549 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0559 | 0.3035 | 0.2151 |
Mycobacterium tuberculosis | Probable serine acetyltransferase CysE (sat) | 0.0071 | 0.0177 | 0.0322 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0882 | 0.4924 | 0.8969 |
Plasmodium falciparum | carbonic anhydrase | 0.0559 | 0.3035 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0559 | 0.3035 | 0.4243 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0237 | 0.1152 | 0.1247 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1624 | 0.9263 | 1 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0237 | 0.1152 | 0.2097 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1624 | 0.9263 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0559 | 0.3035 | 0.3298 |
Leishmania major | cysteine desulfhydrase | 0.0353 | 0.1831 | 0.2258 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1222 | 0.6913 | 1 |
Entamoeba histolytica | ankyrin, putative | 0.0071 | 0.0177 | 0.0218 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0781 | 0.4333 | 0.7893 |
Mycobacterium ulcerans | transferase | 0.0068 | 0.0161 | 0.0174 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1222 | 0.6913 | 1 |
Entamoeba histolytica | acetyltransferase, putative | 0.0071 | 0.0177 | 0.0218 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1426 | 0.8106 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0559 | 0.3035 | 0.4243 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1222 | 0.6913 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0071 | 0.0177 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0559 | 0.3035 | 0.3298 |
Leishmania major | carbonic anhydrase-like protein | 0.1222 | 0.6913 | 0.8528 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0559 | 0.3035 | 0.3298 |
Onchocerca volvulus | Putative sulfate transporter | 0.0206 | 0.0965 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1222 | 0.6913 | 0.6521 |
Echinococcus granulosus | carbonic anhydrase | 0.0559 | 0.3035 | 0.4243 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1222 | 0.6913 | 0.7647 |
Toxoplasma gondii | hypothetical protein | 0.0559 | 0.3035 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0559 | 0.3035 | 0.2151 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1222 | 0.6913 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.1426 | 0.8106 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0559 | 0.3035 | 0.2151 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0559 | 0.3035 | 0.3298 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1222 | 0.6913 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.