Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Rrm3p helicase | 0.0028 | 0.097 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0044 | 0.3239 | 0.3239 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0025 | 0.0529 | 0.0529 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0044 | 0.3239 | 0.3633 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | steroid hormone receptor | 0.0044 | 0.3239 | 0.3633 |
Schistosoma mansoni | thyroid hormone receptor | 0.0044 | 0.3239 | 0.3239 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0085 | 0.8915 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3239 | 0.3633 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0044 | 0.3239 | 0.3239 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0044 | 0.3239 | 0.3633 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0023 | 0.0347 | 0.0347 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0044 | 0.3239 | 0.3633 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0036 | 0.2106 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0044 | 0.3239 | 0.3239 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0036 | 0.2106 | 0.2362 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0036 | 0.2106 | 0.2362 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0347 | 0.0389 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3239 | 0.3633 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0044 | 0.3239 | 0.3633 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0023 | 0.0347 | 0.0347 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0044 | 0.3239 | 0.3633 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0044 | 0.3239 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0079 | 0.8138 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3239 | 0.3633 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | Cytochrome P450 family protein | 0.0037 | 0.2311 | 0.2592 |
Schistosoma mansoni | coup transcription factor | 0.0044 | 0.3239 | 0.3239 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0037 | 0.2311 | 0.2592 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.097 | 0.097 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3239 | 0.3633 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0025 | 0.0529 | 0.0593 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0347 | 0.0389 |
Echinococcus granulosus | ATP dependent DNA helicase PIF1 | 0.0028 | 0.097 | 0.1088 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0044 | 0.3239 | 0.3239 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0044 | 0.3239 | 0.3633 |
Echinococcus granulosus | voltage gated potassium channel | 0.0025 | 0.0529 | 0.0593 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0044 | 0.3239 | 0.3633 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0085 | 0.8915 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | nuclear hormone receptor | 0.0044 | 0.3239 | 0.3633 |
Leishmania major | cytochrome p450-like protein | 0.0036 | 0.2106 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0079 | 0.8138 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0044 | 0.3239 | 0.3239 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0036 | 0.2106 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0044 | 0.3239 | 0.3633 |
Schistosoma mansoni | thyroid hormone receptor | 0.0044 | 0.3239 | 0.3239 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0044 | 0.3239 | 0.3633 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3239 | 0.3633 |
Echinococcus granulosus | FTZ F1 alpha | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0023 | 0.0347 | 0.0389 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0044 | 0.3239 | 0.3239 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.7356 | 0.8251 |
Trypanosoma brucei | cytochrome P450, putative | 0.0036 | 0.2106 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0025 | 0.0529 | 0.0593 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0085 | 0.8915 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0023 | 0.0347 | 0.0389 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0044 | 0.3239 | 0.3633 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0044 | 0.3239 | 0.3633 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0044 | 0.3239 | 0.3633 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0044 | 0.3239 | 0.3239 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0347 | 0.0389 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0044 | 0.3239 | 0.3633 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0044 | 0.3239 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0347 | 0.0389 |
Onchocerca volvulus | 0.0044 | 0.3239 | 1 | |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0023 | 0.0347 | 0.0389 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0028 | 0.097 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0023 | 0.0347 | 0.0389 |
Brugia malayi | Cytochrome P450 family protein | 0.0036 | 0.2106 | 0.2362 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0044 | 0.3239 | 0.3633 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0044 | 0.3239 | 0.3633 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0025 | 0.0529 | 0.0529 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0347 | 0.0389 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0023 | 0.0347 | 0.0389 |
Brugia malayi | nuclear receptor NHR-88 | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0025 | 0.0529 | 0.0593 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | ecdysteroid receptor | 0.0044 | 0.3239 | 0.3633 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0044 | 0.3239 | 0.3633 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0028 | 0.097 | 0.5 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0347 | 0.0389 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0347 | 0.0389 |
Schistosoma mansoni | nuclear hormone receptor | 0.0044 | 0.3239 | 0.3239 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0023 | 0.0347 | 0.0389 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0044 | 0.3239 | 0.3633 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0036 | 0.2106 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0044 | 0.3239 | 0.3633 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0085 | 0.8915 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3239 | 0.3633 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0044 | 0.3239 | 0.3239 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0044 | 0.3239 | 0.3239 |
Brugia malayi | Cytochrome P450 family protein | 0.0036 | 0.2106 | 0.2362 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0025 | 0.0529 | 0.0593 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0036 | 0.2106 | 0.2362 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0044 | 0.3239 | 0.3633 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0044 | 0.3239 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0044 | 0.3239 | 0.3633 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0044 | 0.3239 | 0.3633 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0529 | 0.0593 |
Echinococcus multilocularis | ATP dependent DNA helicase PIF1 | 0.0028 | 0.097 | 0.1088 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.