Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | biotin-(acetyl-CoA carboxylase) ligase | 0.0256 | 0.1827 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0268 | 0.1924 | 1 |
Leishmania major | biotin/lipoate protein ligase-like protein | 0.0256 | 0.1827 | 1 |
Chlamydia trachomatis | hypothetical protein | 0.0268 | 0.1924 | 1 |
Plasmodium vivax | biotin--[acetyl-CoA-carboxylase] synthetase, putative | 0.0256 | 0.1827 | 1 |
Brugia malayi | lipoate-protein ligase, mitochondrial precursor, putative | 0.0074 | 0.0431 | 0.0474 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0256 | 0.1827 | 1 |
Trichomonas vaginalis | nicotinate phosphoribosyltransferase, putative | 0.0152 | 0.1031 | 1 |
Onchocerca volvulus | Lipoyltransferase 1, mitochondrial homolog | 0.0074 | 0.0431 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0037 | 0.0145 | 0.0118 |
Trypanosoma brucei | nicotinate phosphoribosyltransferase, putative | 0.0152 | 0.1031 | 0.4297 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0268 | 0.1924 | 1 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase | 0.0152 | 0.1031 | 0.167 |
Plasmodium falciparum | biotin protein ligase, putative | 0.0256 | 0.1827 | 1 |
Echinococcus granulosus | N terminal of biotin protein ligase | 0.0268 | 0.1924 | 0.2601 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0059 | 0.0088 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | 0.082 | 0.6171 | 1 |
Mycobacterium tuberculosis | Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (biotin--protein ligas | 0.0181 | 0.1257 | 0.1645 |
Onchocerca volvulus | Putative lipoyltransferase 2, mitochondrial | 0.0074 | 0.0431 | 0.5 |
Mycobacterium tuberculosis | Nicotinic acid phosphoribosyltransferase PncB1 | 0.0152 | 0.1031 | 0.1195 |
Schistosoma mansoni | biotin-protein ligase | 0.0256 | 0.1827 | 0.2961 |
Echinococcus multilocularis | biotin protein ligase | 0.0256 | 0.1827 | 0.2876 |
Plasmodium falciparum | biotin--acetyl-CoA-carboxylase, putative | 0.0256 | 0.1827 | 1 |
Echinococcus granulosus | 5'partial|biotin protein ligase | 0.0181 | 0.1257 | 0.1439 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0091 | 0.056 | 0.0899 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0079 | 0.0119 |
Treponema pallidum | biotin--acetyl-CoA-carboxylase ligase | 0.0727 | 0.5452 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0125 | 0.0195 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0268 | 0.1924 | 1 |
Brugia malayi | lipoate-protein ligase B containing protein | 0.0074 | 0.0431 | 0.0474 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.1257 | 0.203 |
Toxoplasma gondii | lipoyl(octanoyl) transferase | 0.0074 | 0.0431 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0055 | 0.0284 | 0.0231 |
Chlamydia trachomatis | biotin synthetase | 0.0256 | 0.1827 | 0.9353 |
Mycobacterium ulcerans | bifunctional protein BirA | 0.0652 | 0.4881 | 0.4651 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0268 | 0.1924 | 1 |
Trypanosoma cruzi | nicotinate phosphoribosyltransferase, putative | 0.0152 | 0.1031 | 0.4297 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0091 | 0.056 | 0.0224 |
Brugia malayi | biotin--acetyl-CoA-carboxylase ligase family protein | 0.0256 | 0.1827 | 0.2791 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0091 | 0.056 | 0.0797 |
Mycobacterium tuberculosis | Nicotinic acid phosphoribosyltransferase PncB2 | 0.0152 | 0.1031 | 0.1195 |
Mycobacterium leprae | POSSIBLE BIFUNCTIONAL PROTEIN BirA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGAS | 0.0181 | 0.1257 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0268 | 0.1924 | 1 |
Plasmodium falciparum | nicotinate phosphoribosyltransferase, putative | 0.0152 | 0.1031 | 0.4297 |
Entamoeba histolytica | biotin--acetyl-CoA-carboxylase ligase, putative | 0.0256 | 0.1827 | 0.9308 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0268 | 0.1924 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0268 | 0.1924 | 1 |
Leishmania major | nicotinate phosphoribosyltransferase, putative | 0.0152 | 0.1031 | 0.4297 |
Loa Loa (eye worm) | pre-B cell enhancing factor | 0.082 | 0.6171 | 1 |
Loa Loa (eye worm) | biotin protein ligase 1 | 0.0256 | 0.1827 | 0.2955 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.1257 | 0.203 |
Schistosoma mansoni | lipoate-protein ligase B | 0.0074 | 0.0431 | 0.0698 |
Giardia lamblia | Hypothetical protein | 0.0256 | 0.1827 | 0.5 |
Echinococcus multilocularis | octanoyltransferase, mitochondrial | 0.0074 | 0.0431 | 0.0586 |
Entamoeba histolytica | nicotinate phosphoribosyltransferase, putative | 0.0152 | 0.1031 | 0.3605 |
Echinococcus granulosus | nicotinamide phosphoribosyltransferase | 0.082 | 0.6171 | 1 |
Echinococcus multilocularis | biotin protein ligase | 0.0256 | 0.1827 | 0.2876 |
Trypanosoma brucei | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0256 | 0.1827 | 1 |
Echinococcus multilocularis | nicotinamide phosphoribosyltransferase | 0.082 | 0.6171 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0431 | 0.069 |
Schistosoma mansoni | biotin-protein ligase | 0.0268 | 0.1924 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.009 | 0.0549 | 0.089 |
Brugia malayi | Pre-B cell enhancing factor precursor | 0.082 | 0.6171 | 1 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | 0.0152 | 0.1031 | 0.167 |
Echinococcus multilocularis | N terminal of biotin protein ligase | 0.0268 | 0.1924 | 0.3034 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0268 | 0.1924 | 1 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0256 | 0.1827 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0268 | 0.1924 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.