Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D3 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | dopamine receptor D3 | 400 aa | 392 aa | 19.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0038 | 0.0825 | 0.192 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.088 | 0.1064 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.088 | 0.2409 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0038 | 0.0825 | 0.2153 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0095 | 0.2519 | 1 |
Brugia malayi | beta-lactamase | 0.004 | 0.088 | 0.1064 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.088 | 0.1987 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.088 | 0.1278 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.088 | 0.1278 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.088 | 0.5 |
Giardia lamblia | Telomerase catalytic subunit | 0.0095 | 0.2519 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0047 | 0.1096 | 0.3408 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.0825 | 0.2153 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.088 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.088 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.088 | 0.1278 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0095 | 0.2519 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.088 | 0.1278 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0095 | 0.2519 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.088 | 0.2409 |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0038 | 0.0825 | 0.1862 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0038 | 0.0825 | 0.2153 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.088 | 0.1064 |
Brugia malayi | hypothetical protein | 0.0022 | 0.036 | 0.0328 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0095 | 0.2519 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.088 | 0.1278 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.088 | 0.2409 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.088 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.088 | 0.2409 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0047 | 0.1096 | 1 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0043 | 0.098 | 0.5 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0047 | 0.1096 | 1 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0038 | 0.0825 | 0.2153 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.016 | 0.4429 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.016 | 0.4429 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0095 | 0.2519 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.016 | 0.4429 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.088 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.088 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.088 | 0.2048 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0038 | 0.0825 | 0.1142 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0047 | 0.1096 | 0.3408 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0095 | 0.2519 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0095 | 0.2519 | 1 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0038 | 0.0825 | 0.2153 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0043 | 0.098 | 0.2872 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.088 | 0.1278 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0038 | 0.0825 | 0.2153 |
Brugia malayi | Telomerase reverse transcriptase | 0.0253 | 0.7189 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0155 | 0.4296 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.088 | 0.1987 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0253 | 0.7201 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.088 | 0.5 |
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0038 | 0.0825 | 0.2153 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0038 | 0.0825 | 0.2153 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.088 | 0.1278 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.088 | 0.1278 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.016 | 0.4429 | 0.6091 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.088 | 0.2409 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0038 | 0.0825 | 0.2153 |
Brugia malayi | Augmenter of liver regeneration | 0.0038 | 0.0825 | 0.0986 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0047 | 0.1096 | 0.3408 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.088 | 0.1064 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.088 | 0.2409 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0047 | 0.1096 | 0.255 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.088 | 0.1987 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 467 nM | Displacement of [125I]-IABN from human dopamine D3 receptor expressed in HEK293 cells after 60 mins by gamma counting | ChEMBL. | 21495689 |
Ki (binding) | = 5270 nM | Displacement of [125I]-IABN from human dopamine D2L receptor expressed in HEK293 cells after 60 mins by gamma counting | ChEMBL. | 21495689 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.