Detailed information for compound 1509410

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 306.319 | Formula: C17H14N4O2
  • H donors: 3 H acceptors: 4 LogP: 2.46 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)c1cnc(c(n1)C(=O)Nc1ccccc1)N
  • InChi: 1S/C17H14N4O2/c18-16-15(17(23)20-12-4-2-1-3-5-12)21-14(10-19-16)11-6-8-13(22)9-7-11/h1-10,22H,(H2,18,19)(H,20,23)
  • InChiKey: QJKUDZZDLFBGDS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein kinase, DNA-activated, catalytic polypeptide Starlite/ChEMBL References
Homo sapiens ATR serine/threonine kinase Starlite/ChEMBL References
Homo sapiens ATM serine/threonine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase Get druggable targets OG5_128955 All targets in OG5_128955
Cryptosporidium parvum FRP1 like protein involved in DNA repair with a FAT domain and a phosphatidylinositol kinase domain at the C-terminus Get druggable targets OG5_128386 All targets in OG5_128386
Trypanosoma brucei gambiense phosphatidylinositol kinase domain protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum Serine/threonine-protein kinase ATR, putative Get druggable targets OG5_128386 All targets in OG5_128386
Leishmania major phosphatidylinositol 3-related kinase, putative Get druggable targets OG5_128386 All targets in OG5_128386
Leishmania major phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania infantum phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans potential phosphatidylinositol kinase similar to S. cerevisiae MEC1 (YBR136W) involved in DNA repair and recombination Get druggable targets OG5_128386 All targets in OG5_128386
Trypanosoma brucei phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania braziliensis phosphatidylinositol 3-related kinase, putative Get druggable targets OG5_128386 All targets in OG5_128386
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128386 All targets in OG5_128386
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128386 All targets in OG5_128386
Trypanosoma brucei gambiense phosphatidylinositol 3-related kinase, putative Get druggable targets OG5_128386 All targets in OG5_128386
Echinococcus multilocularis serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative Get druggable targets OG5_128386 All targets in OG5_128386
Babesia bovis phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_128386 All targets in OG5_128386
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase Get druggable targets OG5_128386 All targets in OG5_128386
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative Get druggable targets OG5_128386 All targets in OG5_128386
Cryptosporidium hominis ataxia telangiectasia and Rad3-related protein Get druggable targets OG5_128386 All targets in OG5_128386
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus granulosus DNA dependent protein kinase catalytic subunit Get druggable targets OG5_132688 All targets in OG5_132688
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit Get druggable targets OG5_132688 All targets in OG5_132688
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_128386 All targets in OG5_128386
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128386 All targets in OG5_128386
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania donovani phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128386 All targets in OG5_128386
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative Get druggable targets OG5_128386 All targets in OG5_128386
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_128386 All targets in OG5_128386
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase Get druggable targets OG5_128386 All targets in OG5_128386
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum Serine/threonine-protein kinase atr, putative Get druggable targets OG5_128386 All targets in OG5_128386
Leishmania donovani phosphatidylinositol 3-related kinase, putative Get druggable targets OG5_128386 All targets in OG5_128386
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family Get druggable targets OG5_128386 All targets in OG5_128386
Entamoeba histolytica hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128386 All targets in OG5_128386
Schistosoma japonicum ko:K04728 ataxia telangectasia mutated family protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma mansoni ataxia telangiectasia mutated (atm) Get druggable targets OG5_128955 All targets in OG5_128955
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans potential phosphatidylinositol kinase similar to S. cerevisiae MEC1 (YBR136W) involved in DNA repair and recombination Get druggable targets OG5_128386 All targets in OG5_128386
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_128386 All targets in OG5_128386
Leishmania braziliensis phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum ko:K06640 ataxia telangiectasia and Rad3 related, putative Get druggable targets OG5_128386 All targets in OG5_128386
Toxoplasma gondii FATC domain-containing protein Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Neospora caninum phosphatidylinositol 3- and 4-kinase domain- containing protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_128386 All targets in OG5_128386
Echinococcus granulosus serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania infantum phosphatidylinositol 3-related kinase, putative Get druggable targets OG5_128386 All targets in OG5_128386
Leishmania mexicana phosphatidylinositol 3-related kinase, putative Get druggable targets OG5_128386 All targets in OG5_128386
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase Get druggable targets OG5_128386 All targets in OG5_128386
Leishmania mexicana phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing Get druggable targets OG5_128955 All targets in OG5_128955
Neospora caninum phosphatidylinositol 3- and 4-kinase domain- containing protein, putative Get druggable targets OG5_128386 All targets in OG5_128386
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus fmrfamide receptor 0.0151 0.3899 0.3592
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0151 0.3899 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Echinococcus granulosus biogenic amine 5HT receptor 0.0151 0.3899 0.3592
Brugia malayi Dopamine receptor protein 2 0.0151 0.3899 1
Echinococcus multilocularis somatostatin receptor 0.0151 0.3899 0.3592
Brugia malayi hypothetical protein 0.0151 0.3899 1
Loa Loa (eye worm) G-protein coupled receptor 0.0151 0.3899 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0151 0.3899 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Onchocerca volvulus 0.0151 0.3899 0.5
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Brugia malayi RE15519p 0.0151 0.3899 1
Brugia malayi ORL1-like opioid receptor 0.0151 0.3899 1
Echinococcus multilocularis sex peptide receptor 0.0151 0.3899 0.3592
Brugia malayi hypothetical protein 0.0151 0.3899 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0151 0.3899 0.3592
Loa Loa (eye worm) neuropeptide F receptor 0.0151 0.3899 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0066 0.0867 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0066 0.0867 0.0407
Schistosoma mansoni neuropeptide receptor 0.0151 0.3899 1
Echinococcus granulosus neuropeptide receptor 0.0151 0.3899 0.3592
Schistosoma mansoni neuropeptide receptor 0.0151 0.3899 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0151 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0126 0.3031 0.268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Echinococcus granulosus rhodopsin orphan GPCR 0.0151 0.3899 0.3592
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0151 0.3899 1
Onchocerca volvulus 0.0151 0.3899 0.5
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0151 0.3899 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0151 0.3899 1
Echinococcus multilocularis g protein coupled receptor 0.0151 0.3899 0.3592
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0055 0.0479 0.1497
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0479 0.3608
Echinococcus multilocularis neuropeptides capa receptor 0.0151 0.3899 0.3592
Schistosoma mansoni biogenic amine receptor 0.0151 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0151 0.3899 0.3592
Echinococcus granulosus neuropeptide FF receptor 2 0.0151 0.3899 0.3592
Onchocerca volvulus 0.0151 0.3899 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0151 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Echinococcus granulosus tm gpcr rhodopsin 0.0151 0.3899 0.3592
Echinococcus granulosus rhodopsin orphan GPCR 0.0151 0.3899 0.3592
Schistosoma mansoni opsin-like receptor 0.0151 0.3899 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0311 0.2342
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0151 0.3899 0.3592
Onchocerca volvulus 0.0151 0.3899 0.5
Schistosoma mansoni biogenic amine receptor 0.0151 0.3899 1
Schistosoma mansoni hypothetical protein 0.0151 0.3899 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0126 0.3031 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0151 0.3899 0.3592
Schistosoma mansoni opsin-like receptor 0.0151 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0151 0.3899 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0151 0.3899 0.3592
Entamoeba histolytica hypothetical protein 0.0055 0.0479 0.3025
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Echinococcus granulosus neuropeptide receptor 0.0151 0.3899 0.3592
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0151 0.3899 1
Onchocerca volvulus 0.0151 0.3899 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0078 0.1329 1
Leishmania major hypothetical protein, conserved 0.0122 0.2888 1
Loa Loa (eye worm) TYRA-2 protein 0.0151 0.3899 1
Brugia malayi hypothetical protein 0.0151 0.3899 1
Echinococcus multilocularis neuropeptides capa receptor 0.0151 0.3899 0.3592
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0151 0.3899 0.3592
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0151 0.3899 0.3592
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Schistosoma mansoni histamine h1 receptor 0.0151 0.3899 1
Brugia malayi Dopamine receptor protein 1 0.0151 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0151 0.3899 1
Echinococcus granulosus neuropeptides capa receptor 0.0151 0.3899 0.3592
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0151 0.3899 0.3592
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0151 0.3899 0.3592
Brugia malayi hypothetical protein 0.0151 0.3899 1
Echinococcus granulosus tm gpcr rhodopsin 0.0151 0.3899 0.3592
Loa Loa (eye worm) phosphatidylinositol 3 0.0078 0.1329 0.3408
Onchocerca volvulus 0.0151 0.3899 0.5
Echinococcus granulosus alpha 1A adrenergic receptor 0.0151 0.3899 0.3592
Onchocerca volvulus 0.0151 0.3899 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0151 0.3899 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Echinococcus multilocularis fmrfamide receptor 0.0151 0.3899 0.3592
Echinococcus multilocularis g protein coupled receptor 0.0151 0.3899 0.3592
Echinococcus granulosus tachykinin peptides receptor 99D 0.0151 0.3899 0.3592
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0151 0.3899 1
Echinococcus granulosus neuropeptide Y receptor 0.0151 0.3899 0.3592
Brugia malayi Tachykinin-like peptides receptor 99D 0.0151 0.3899 1
Echinococcus granulosus g protein coupled receptor 0.0151 0.3899 0.3592
Echinococcus granulosus tm gpcr rhodopsin 0.0151 0.3899 0.3592
Onchocerca volvulus 0.0151 0.3899 0.5
Echinococcus multilocularis allatostatin A receptor 0.0151 0.3899 0.3592
Echinococcus granulosus somatostatin receptor 0.0151 0.3899 0.3592
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0151 0.3899 0.3592
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0151 0.3899 0.3592
Schistosoma mansoni hypothetical protein 0.0151 0.3899 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0066 0.0867 0.6526
Schistosoma mansoni adenoreceptor 0.0151 0.3899 1
Schistosoma mansoni amine GPCR 0.0151 0.3899 1
Schistosoma mansoni hypothetical protein 0.0151 0.3899 1
Brugia malayi hypothetical protein 0.0151 0.3899 1
Echinococcus multilocularis g protein coupled receptor 0.0151 0.3899 0.3592
Loa Loa (eye worm) hypothetical protein 0.0042 0.003 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Echinococcus granulosus rhodopsin orphan GPCR 0.0151 0.3899 0.3592
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0151 0.3899 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Onchocerca volvulus 0.0151 0.3899 0.5
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0066 0.0867 0.1134
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Echinococcus multilocularis orexin receptor type 2 0.0151 0.3899 0.3592
Echinococcus granulosus serotonin receptor 0.0151 0.3899 0.3592
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Brugia malayi putative neuropeptide receptor 0.0151 0.3899 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0151 0.3899 0.3592
Onchocerca volvulus Neuropeptide F receptor homolog 0.0151 0.3899 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0151 0.3899 0.3592
Echinococcus granulosus 7tm_1 domain containing protein 0.0151 0.3899 0.3592
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0151 0.3899 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Brugia malayi hypothetical protein 0.0151 0.3899 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0151 0.3899 0.3592
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Echinococcus granulosus rhodopsin orphan GPCR 0.0151 0.3899 0.3592
Brugia malayi hypothetical protein 0.0151 0.3899 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0066 0.0867 0.2789
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0066 0.0867 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0151 0.3899 0.3592
Echinococcus multilocularis neuropeptide FF receptor 2 0.0151 0.3899 0.3592
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0151 0.3899 1
Echinococcus multilocularis serotonin receptor 0.0151 0.3899 0.3592
Schistosoma mansoni biogenic amine (5HT) receptor 0.0151 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Echinococcus multilocularis neuropeptide receptor 0.0151 0.3899 0.3592
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0151 0.3899 1
Schistosoma mansoni amine GPCR 0.0151 0.3899 1
Brugia malayi hypothetical protein 0.0151 0.3899 1
Echinococcus granulosus dro:myosuppressin receptor 0.0151 0.3899 0.3592
Brugia malayi G protein-coupled receptor 0.0151 0.3899 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0151 0.3899 1
Onchocerca volvulus 0.0151 0.3899 0.5
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Echinococcus multilocularis neuropeptide receptor A26 0.0151 0.3899 0.3592
Echinococcus granulosus neuropeptide receptor A26 0.0151 0.3899 0.3592
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Onchocerca volvulus 0.0151 0.3899 0.5
Onchocerca volvulus 0.0151 0.3899 0.5
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Echinococcus multilocularis serotonin receptor 0.0151 0.3899 0.3592
Echinococcus granulosus allatostatin A receptor 0.0151 0.3899 0.3592
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0151 0.3899 0.3592
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0151 0.3899 0.3592
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0151 0.3899 1
Schistosoma mansoni amine GPCR 0.0151 0.3899 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0151 0.3899 0.3592
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Schistosoma mansoni amine GPCR 0.0151 0.3899 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0151 0.3899 0.3592
Brugia malayi neuropeptide F receptor 0.0151 0.3899 1
Echinococcus granulosus hypothetical protein 0.0151 0.3899 0.3592
Brugia malayi hypothetical protein 0.0151 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Echinococcus granulosus g protein coupled receptor 0.0151 0.3899 0.3592
Toxoplasma gondii FATC domain-containing protein 0.0055 0.0479 0.5528
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0151 0.3899 0.3592
Schistosoma mansoni opsin-like receptor 0.0151 0.3899 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Echinococcus granulosus g-protein coupled receptor 0.0151 0.3899 0.3592
Echinococcus granulosus orexin receptor type 2 0.0151 0.3899 0.3592
Echinococcus multilocularis rhodopsin orphan GPCR 0.0151 0.3899 0.3592
Onchocerca volvulus 0.0151 0.3899 0.5
Onchocerca volvulus 0.0151 0.3899 0.5
Trypanosoma cruzi target of rapamycin kinase 3 0.0066 0.0867 0.2789
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Echinococcus granulosus biogenic amine 5HT receptor 0.0151 0.3899 0.3592
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0151 0.3899 1
Schistosoma mansoni amine GPCR 0.0151 0.3899 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0151 0.3899 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0151 0.3899 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0151 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Schistosoma mansoni neuropeptide receptor 0.0151 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0078 0.1329 1
Brugia malayi Melatonin receptor type 1A 0.0151 0.3899 1
Brugia malayi follicle stimulating hormone receptor 0.0151 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0151 0.3899 0.3592
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0151 0.3899 1
Brugia malayi Serotonin receptor 0.0151 0.3899 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0151 0.3899 0.3592
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0126 0.3031 0.7461
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0055 0.0479 0.3608
Echinococcus granulosus sex peptide receptor 0.0151 0.3899 0.3592
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0151 0.3899 0.3592
Echinococcus granulosus neuropeptide s receptor 0.0151 0.3899 0.3592
Brugia malayi Dopamine receptor 0.0151 0.3899 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0151 0.3899 0.3592
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0066 0.0867 0.1134
Giardia lamblia GTOR 0.0066 0.0867 0.5
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Onchocerca volvulus 0.0151 0.3899 0.5
Brugia malayi G-protein coupled receptor 0.0151 0.3899 1
Brugia malayi hypothetical protein 0.0151 0.3899 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0151 0.3899 0.3592
Schistosoma mansoni neuropeptide receptor 0.0151 0.3899 1
Echinococcus multilocularis neuropeptide receptor 0.0151 0.3899 0.3592
Onchocerca volvulus 0.0151 0.3899 0.5
Brugia malayi AKH receptor 0.0151 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Echinococcus granulosus neuropeptide Y receptor 0.0151 0.3899 0.3592
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0151 0.3899 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0078 0.1329 0.2284
Brugia malayi Serotonin receptor 0.0151 0.3899 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0151 0.3899 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0151 0.3899 0.3592
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0151 0.3899 0.3592
Echinococcus multilocularis g-protein coupled receptor 0.0151 0.3899 0.3592
Brugia malayi sulfakinin receptor protein 0.0151 0.3899 1
Onchocerca volvulus 0.0151 0.3899 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.0151 0.3899 1
Loa Loa (eye worm) G-protein coupled receptor 0.0151 0.3899 1
Schistosoma mansoni hypothetical protein 0.0151 0.3899 1
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.2439 0.8027
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0151 0.3899 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0066 0.0867 0.2789
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0151 0.3899 1
Schistosoma mansoni neuropeptide F-like receptor 0.0151 0.3899 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Brugia malayi larval opioid receptor 0.0151 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Echinococcus granulosus G protein coupled receptor 139 0.0151 0.3899 0.3592
Echinococcus multilocularis neuropeptide s receptor 0.0151 0.3899 0.3592
Echinococcus multilocularis G protein coupled receptor 139 0.0151 0.3899 0.3592
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Echinococcus multilocularis fmrfamide receptor 0.0151 0.3899 0.3592
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0066 0.0867 1
Brugia malayi GnHR receptor homolog 0.0151 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0066 0.0867 0.0407
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0151 0.3899 0.3592
Echinococcus multilocularis neuropeptide Y receptor 0.0151 0.3899 0.3592
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0151 0.3899 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0151 0.3899 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0126 0.3031 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0151 0.3899 0.3592
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0066 0.0867 0.6526
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Schistosoma mansoni biogenic amine receptor 0.0151 0.3899 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Brugia malayi neuropeptide F receptor 0.0151 0.3899 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0151 0.3899 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0151 0.3899 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0151 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0066 0.0867 0.6526
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0151 0.3899 1
Brugia malayi putative neuropeptide receptor NPR1 0.0151 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0126 0.3031 0.7461
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0151 0.3899 0.3592
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0151 0.3899 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Schistosoma mansoni myosin xvIII 0.0151 0.3899 1
Echinococcus granulosus neuropeptides capa receptor 0.0151 0.3899 0.3592
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Echinococcus granulosus g protein coupled receptor 0.0151 0.3899 0.3592
Loa Loa (eye worm) neuropeptide F receptor 0.0151 0.3899 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0126 0.3031 0.268
Loa Loa (eye worm) phosphatidylinositol 3 0.0066 0.0867 0.2224
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0066 0.0867 0.6526
Loa Loa (eye worm) melatonin receptor type 1A 0.0151 0.3899 1
Brugia malayi G-protein coupled receptor 0.0151 0.3899 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.0867 0.6526
Echinococcus multilocularis rhodopsin orphan GPCR 0.0151 0.3899 0.3592
Echinococcus granulosus rhodopsin orphan GPCR 0.0151 0.3899 0.3592
Echinococcus multilocularis rhodopsin orphan GPCR 0.0151 0.3899 0.3592
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0151 0.3899 1
Echinococcus multilocularis neuropeptide Y receptor 0.0151 0.3899 0.3592
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0151 0.3899 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.3899 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0151 0.3899 0.3592
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0151 0.3899 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0151 0.3899 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.32 uM Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assay ChEMBL. 21413798
IC50 (binding) = 1.8 uM Inhibition of DNAPK after 2 hrs by radiometric phosphate incorporation assay ChEMBL. 21413798
IC50 (binding) = 5.8 uM Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay ChEMBL. 21413798

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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