Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase kinase kinase 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0237 | 0.1869 | 0.7355 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0295 | 0.2541 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0295 | 0.2541 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0295 | 0.2541 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0652 | 0.2564 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0295 | 0.2541 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0344 | 0.1355 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0295 | 0.2541 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0409 | 0.3862 | 0.5 |
Giardia lamblia | DNA topoisomerase II | 0.027 | 0.2246 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0249 | 0.2009 | 0.7903 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0295 | 0.2541 | 0.5 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0295 | 0.2541 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0295 | 0.2541 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0295 | 0.2541 | 0.5 |
Schistosoma mansoni | DNA topoisomerase II | 0.0295 | 0.2541 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0652 | 0.2564 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0533 | 0.5291 | 0.4508 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0295 | 0.2541 | 0.5 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0533 | 0.5291 | 0.5123 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0533 | 0.5291 | 0.4508 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0533 | 0.5291 | 0.3687 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0344 | 0.1355 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0295 | 0.2541 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0533 | 0.5291 | 0.3687 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0295 | 0.2541 | 0.1404 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0237 | 0.1869 | 0.7355 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0295 | 0.2541 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0533 | 0.5291 | 0.5123 |
Brugia malayi | Probable DNA topoisomerase II | 0.0295 | 0.2541 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0295 | 0.2541 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0295 | 0.2541 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10 uM | Competitive inhibition of human ASK1 | ChEMBL. | 21449566 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.