Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | RAR-like nuclear receptor | 0.0437 | 0.3287 | 0.5629 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.057 | 0.442 | 0.7629 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0437 | 0.3287 | 0.3287 |
Brugia malayi | nuclear receptor RXR | 0.0258 | 0.1754 | 0.1754 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0437 | 0.3287 | 0.5332 |
Schistosoma mansoni | nuclear receptor | 0.0179 | 0.1084 | 0.1741 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1084 | 0.1084 |
Loa Loa (eye worm) | steroid hormone receptor | 0.1022 | 0.8281 | 0.8281 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0437 | 0.3287 | 0.3287 |
Brugia malayi | Presenilin spe-4 | 0.0076 | 0.0199 | 0.0199 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0217 | 0.1401 | 1 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0516 | 0.3961 | 0.3961 |
Brugia malayi | hypothetical protein | 0.0179 | 0.1084 | 0.1084 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0437 | 0.3287 | 0.5629 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0437 | 0.3287 | 0.5629 |
Brugia malayi | nuclear receptor NHR-67 | 0.0179 | 0.1084 | 0.1084 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0064 | 0.0098 | 0.5 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0179 | 0.1084 | 0.1084 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0258 | 0.1754 | 0.1754 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.1754 | 0.1754 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0437 | 0.3287 | 0.3287 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0133 | 0.0684 | 0.1036 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0437 | 0.3287 | 0.3287 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0437 | 0.3287 | 0.3287 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0133 | 0.0684 | 0.0981 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3287 | 0.3287 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1084 | 0.1084 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0179 | 0.1084 | 0.1084 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0437 | 0.3287 | 0.3287 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0516 | 0.3961 | 0.6819 |
Brugia malayi | tailless protein | 0.0179 | 0.1084 | 0.1084 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0179 | 0.1084 | 0.1649 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0437 | 0.3287 | 0.5629 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.1754 | 0.1754 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1084 | 0.1084 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0203 | 0.1287 | 0.1287 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0098 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0437 | 0.3287 | 0.3287 |
Schistosoma mansoni | thyroid hormone receptor | 0.057 | 0.442 | 0.7629 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3287 | 0.3287 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0437 | 0.3287 | 0.5332 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0437 | 0.3287 | 0.3287 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0217 | 0.1401 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0437 | 0.3287 | 0.5332 |
Brugia malayi | nuclear receptor NHR-88 | 0.0437 | 0.3287 | 0.3287 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0217 | 0.1401 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0437 | 0.3287 | 0.5629 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.1754 | 0.1754 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0437 | 0.3287 | 0.5629 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3287 | 0.3287 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0541 | 0.4174 | 0.6816 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0437 | 0.3287 | 0.5629 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0727 | 0.5763 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0258 | 0.1754 | 0.2923 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0437 | 0.3287 | 0.5332 |
Brugia malayi | hypothetical protein | 0.0258 | 0.1754 | 0.1754 |
Schistosoma mansoni | thyroid hormone receptor | 0.057 | 0.442 | 0.7629 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1084 | 0.1084 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1084 | 0.1084 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1084 | 0.1084 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3287 | 0.3287 |
Brugia malayi | nuclear receptor RXR | 0.0179 | 0.1084 | 0.1084 |
Loa Loa (eye worm) | presenilin spe-4 | 0.0076 | 0.0199 | 0.0199 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0179 | 0.1084 | 0.1084 |
Brugia malayi | conserved hypotetical protein | 0.0179 | 0.1084 | 0.1084 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0437 | 0.3287 | 0.3287 |
Brugia malayi | Presenilin family protein | 0.0217 | 0.1401 | 0.1401 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0179 | 0.1084 | 0.1741 |
Brugia malayi | Presenilin spe-4 | 0.0076 | 0.0199 | 0.0199 |
Echinococcus granulosus | presenilin | 0.0217 | 0.1401 | 0.2178 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0437 | 0.3287 | 0.3287 |
Brugia malayi | hypothetical protein | 0.0258 | 0.1754 | 0.1754 |
Echinococcus granulosus | Nicastrin | 0.0106 | 0.0453 | 0.0593 |
Schistosoma mansoni | zinc finger protein | 0.0179 | 0.1084 | 0.1741 |
Brugia malayi | N-terminal motif family protein | 0.019 | 0.1176 | 0.1176 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0217 | 0.1401 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0437 | 0.3287 | 0.5332 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0437 | 0.3287 | 0.3287 |
Brugia malayi | nuclear hormone receptor | 0.0179 | 0.1084 | 0.1084 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0179 | 0.1084 | 0.1084 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0283 | 0.1971 | 0.3307 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0437 | 0.3287 | 0.3287 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0437 | 0.3287 | 0.3287 |
Echinococcus multilocularis | Nicastrin | 0.0106 | 0.0453 | 0.0626 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0179 | 0.1084 | 0.1649 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0217 | 0.1401 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0258 | 0.1754 | 0.1754 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0217 | 0.1401 | 0.23 |
Schistosoma mansoni | nuclear hormone receptor | 0.0179 | 0.1084 | 0.1741 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0437 | 0.3287 | 0.5629 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0437 | 0.3287 | 0.3287 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0541 | 0.4174 | 0.7195 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0437 | 0.3287 | 0.5629 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0179 | 0.1084 | 0.1649 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0437 | 0.3287 | 0.5629 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0727 | 0.5763 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0258 | 0.1754 | 0.2769 |
Onchocerca volvulus | 0.0437 | 0.3287 | 0.247 | |
Brugia malayi | Nuclear hormone receptor E75 | 0.0179 | 0.1084 | 0.1084 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0437 | 0.3287 | 0.5332 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0437 | 0.3287 | 0.3287 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0516 | 0.3961 | 0.6459 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1084 | 0.1084 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0064 | 0.0098 | 0.1936 |
Brugia malayi | hypothetical protein | 0.0106 | 0.0453 | 0.0453 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0217 | 0.1401 | 0.5 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.019 | 0.1176 | 0.0103 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.1754 | 0.1754 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0437 | 0.3287 | 0.5629 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0179 | 0.1084 | 0.1741 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0179 | 0.1084 | 0.1741 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.1754 | 0.1754 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0437 | 0.3287 | 0.3287 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0727 | 0.5763 | 0.9472 |
Echinococcus granulosus | FTZ F1 alpha | 0.0437 | 0.3287 | 0.5332 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0516 | 0.3961 | 0.3961 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0437 | 0.3287 | 0.247 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0179 | 0.1084 | 0.1741 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1084 | 0.1084 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0437 | 0.3287 | 0.3287 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0203 | 0.1287 | 0.1988 |
Schistosoma mansoni | nuclear hormone receptor | 0.0437 | 0.3287 | 0.5629 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1084 | 0.1084 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0179 | 0.1084 | 0.1741 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1084 | 0.1084 |
Brugia malayi | ecdysone receptor | 0.0179 | 0.1084 | 0.1084 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0437 | 0.3287 | 0.3287 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0179 | 0.1084 | 0.1084 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0258 | 0.1754 | 0.1754 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0437 | 0.3287 | 0.5629 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0258 | 0.1754 | 0.2923 |
Schistosoma mansoni | hypothetical protein | 0.0133 | 0.0684 | 0.1036 |
Toxoplasma gondii | hypothetical protein | 0.0076 | 0.0199 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0516 | 0.3961 | 0.6819 |
Brugia malayi | Presenilin spe-4 | 0.0076 | 0.0199 | 0.0199 |
Brugia malayi | hypothetical protein | 0.0106 | 0.0453 | 0.0453 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0064 | 0.0098 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3287 | 0.3287 |
Brugia malayi | hypothetical protein | 0.0076 | 0.0199 | 0.0199 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0437 | 0.3287 | 0.5629 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0179 | 0.1084 | 0.1649 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0453 | 0.0453 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0437 | 0.3287 | 0.5629 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0764 | 0.6078 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0179 | 0.1084 | 0.1084 |
Schistosoma mansoni | hypothetical protein | 0.0106 | 0.0453 | 0.0626 |
Echinococcus multilocularis | presenilin | 0.0217 | 0.1401 | 0.23 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0217 | 0.1401 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0437 | 0.3287 | 0.5629 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.0217 | 0.1401 | 1 |
Brugia malayi | Presenilin-like protein At2g29900 | 0.0076 | 0.0199 | 0.0199 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0098 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3287 | 0.3287 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0437 | 0.3287 | 0.247 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0258 | 0.1754 | 0.2923 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0437 | 0.3287 | 0.3287 |
Brugia malayi | hypothetical protein | 0.0076 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | DR-78 | 0.0179 | 0.1084 | 0.1084 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0179 | 0.1084 | 0.1741 |
Echinococcus multilocularis | Nicastrin | 0.0106 | 0.0453 | 0.0626 |
Brugia malayi | nuclear receptor NHR-88 | 0.0179 | 0.1084 | 0.1084 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0201 | 0.1269 | 0.9012 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0437 | 0.3287 | 0.3287 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0437 | 0.3287 | 0.3287 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0437 | 0.3287 | 0.3287 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0179 | 0.1084 | 0.1084 |
Schistosoma mansoni | nuclear hormone receptor | 0.0179 | 0.1084 | 0.1741 |
Brugia malayi | hypothetical protein | 0.0179 | 0.1084 | 0.1084 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0437 | 0.3287 | 0.5629 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1084 | 0.1084 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0203 | 0.1287 | 0.1287 |
Schistosoma mansoni | nuclear receptor | 0.0179 | 0.1084 | 0.1741 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0437 | 0.3287 | 0.5332 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0179 | 0.1084 | 0.1649 |
Brugia malayi | hypothetical protein | 0.0076 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | hypothetical protein | 0.0437 | 0.3287 | 0.3287 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0179 | 0.1084 | 0.1084 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.1176 | 0.1176 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0203 | 0.1287 | 0.2099 |
Schistosoma mansoni | coup transcription factor | 0.0437 | 0.3287 | 0.5629 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0098 | 0.5 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0179 | 0.1084 | 0.1741 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0179 | 0.1084 | 0.1741 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0437 | 0.3287 | 0.3287 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0437 | 0.3287 | 0.3287 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1084 | 0.1084 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1084 | 0.1084 |
Brugia malayi | steroid hormone receptor | 0.1022 | 0.8281 | 0.8281 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | > 25 uM | Cytotoxicity against human RD cells | ChEMBL. | 21356589 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.