Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0853 | 0.1351 |
Onchocerca volvulus | 0.0154 | 0.6316 | 1 | |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0943 | 0.0943 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0943 | 0.0943 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.0943 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.159 | 0.2266 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0943 | 0.5 |
Echinococcus granulosus | geminin | 0.0172 | 0.7172 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.0943 | 0.1315 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.0943 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.0943 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0853 | 0.119 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0943 | 0.1344 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0943 | 0.1493 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.0943 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0037 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.7015 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.4835 | 0.6893 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0853 | 0.1216 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0943 | 0.1315 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.0943 | 0.1344 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0943 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0943 | 0.1493 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0943 | 0.1344 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.4835 | 0.7656 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0037 | 0.0943 | 0.0943 |
Brugia malayi | hypothetical protein | 0.0154 | 0.6316 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0037 | 0.0943 | 0.0943 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0943 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.0943 | 0.5 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0943 | 0.1493 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0943 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0943 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0169 | 0.7015 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.0943 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0943 | 0.1344 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0943 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.0943 | 0.1315 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0943 | 0.1344 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.7172 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.0943 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0943 | 0.1344 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0943 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0943 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.7015 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.7172 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0943 | 0.1315 |
Echinococcus multilocularis | geminin | 0.0172 | 0.7172 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0037 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.4835 | 0.6893 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.7015 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.159 | 0.2517 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0943 | 0.1344 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.159 | 0.2266 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0037 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0943 | 0.1344 |
Toxoplasma gondii | hypothetical protein | 0.0169 | 0.7015 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.0943 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0943 | 0.1344 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0943 | 0.5 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0037 | 0.0943 | 0.0943 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.0943 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0943 | 0.1493 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.6316 | 0.9003 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0037 | 0.0943 | 0.0943 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.159 | 0.2517 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 430 nM | Binding affinity towards 5-hydroxytryptamine 3 receptor by displacement of [3H]-2 in Neuroblastoma-Glioma NG-108-15 cells | ChEMBL. | 2213824 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.