Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0023 | 0.0271 | 0.0305 |
Brugia malayi | Cytochrome P450 family protein | 0.0033 | 0.1893 | 0.213 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0045 | 0.3632 | 0.4088 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0024 | 0.0389 | 0.0438 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0045 | 0.3632 | 0.4088 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0045 | 0.3632 | 0.4088 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0389 | 0.0438 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0023 | 0.0271 | 0.0305 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0024 | 0.0389 | 0.0438 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0045 | 0.3632 | 0.4088 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0045 | 0.3632 | 0.3632 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0024 | 0.0389 | 0.0389 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0033 | 0.1893 | 0.213 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0023 | 0.0271 | 0.0305 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0079 | 0.8886 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0045 | 0.3632 | 0.4088 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0045 | 0.3632 | 0.4088 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0045 | 0.3632 | 0.4088 |
Brugia malayi | nuclear hormone receptor | 0.0045 | 0.3632 | 0.4088 |
Schistosoma mansoni | nuclear hormone receptor | 0.0045 | 0.3632 | 0.3632 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0023 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0024 | 0.0389 | 0.0438 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0045 | 0.3632 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0045 | 0.3632 | 0.4088 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0271 | 0.0305 |
Onchocerca volvulus | 0.0045 | 0.3632 | 1 | |
Echinococcus granulosus | ATP dependent DNA helicase PIF1 | 0.0031 | 0.1592 | 0.1792 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0023 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0033 | 0.1893 | 0.213 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0045 | 0.3632 | 0.4088 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0079 | 0.8886 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0045 | 0.3632 | 0.4088 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0045 | 0.3632 | 0.4088 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0033 | 0.1893 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0045 | 0.3632 | 0.4088 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3632 | 0.4088 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0045 | 0.3632 | 0.3632 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0045 | 0.3632 | 0.3632 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0033 | 0.1893 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0389 | 0.0438 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0045 | 0.3632 | 0.4088 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0045 | 0.3632 | 0.4088 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0045 | 0.3632 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0389 | 0.0438 |
Giardia lamblia | Rrm3p helicase | 0.0031 | 0.1592 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0045 | 0.3632 | 0.3632 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0045 | 0.3632 | 0.4088 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0045 | 0.3632 | 0.4088 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0045 | 0.3632 | 0.4088 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0389 | 0.0438 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3632 | 0.4088 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0031 | 0.1592 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0045 | 0.3632 | 0.4088 |
Echinococcus granulosus | voltage gated potassium channel | 0.0023 | 0.0271 | 0.0305 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0033 | 0.1893 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0045 | 0.3632 | 0.4088 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0033 | 0.1893 | 0.213 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0045 | 0.3632 | 0.4088 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0045 | 0.3632 | 0.4088 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0023 | 0.0271 | 0.0305 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0045 | 0.3632 | 0.4088 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3632 | 0.4088 |
Brugia malayi | nuclear receptor RXR | 0.0024 | 0.0389 | 0.0438 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0045 | 0.3632 | 0.4088 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3632 | 0.4088 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3632 | 0.4088 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0045 | 0.3632 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0074 | 0.8088 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0045 | 0.3632 | 0.4088 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0045 | 0.3632 | 0.4088 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0035 | 0.2104 | 0.2368 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0045 | 0.3632 | 0.4088 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0045 | 0.3632 | 0.4088 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0045 | 0.3632 | 0.3632 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0389 | 0.0438 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1592 | 0.1592 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0045 | 0.3632 | 0.4088 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0045 | 0.3632 | 0.4088 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3632 | 0.4088 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0079 | 0.8886 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0045 | 0.3632 | 0.3632 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0045 | 0.3632 | 0.3632 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0045 | 0.3632 | 0.3632 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0389 | 0.0438 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0045 | 0.3632 | 0.4088 |
Brugia malayi | Cytochrome P450 family protein | 0.0033 | 0.1893 | 0.213 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0045 | 0.3632 | 0.4088 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0045 | 0.3632 | 0.3632 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0045 | 0.3632 | 0.4088 |
Brugia malayi | steroid hormone receptor | 0.0045 | 0.3632 | 0.4088 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0079 | 0.8886 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0045 | 0.3632 | 0.4088 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0045 | 0.3632 | 0.4088 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0045 | 0.3632 | 0.4088 |
Brugia malayi | nuclear receptor NHR-88 | 0.0045 | 0.3632 | 0.4088 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0045 | 0.3632 | 0.4088 |
Leishmania major | cytochrome p450-like protein | 0.0033 | 0.1893 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0033 | 0.1893 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0074 | 0.8088 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0045 | 0.3632 | 0.3632 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0045 | 0.3632 | 0.4088 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0045 | 0.3632 | 0.4088 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3632 | 0.4088 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0045 | 0.3632 | 0.4088 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0045 | 0.3632 | 0.3632 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.7284 | 0.8197 |
Echinococcus granulosus | FTZ F1 alpha | 0.0045 | 0.3632 | 0.4088 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0024 | 0.0389 | 0.0389 |
Schistosoma mansoni | coup transcription factor | 0.0045 | 0.3632 | 0.3632 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0045 | 0.3632 | 0.4088 |
Brugia malayi | Cytochrome P450 family protein | 0.0035 | 0.2104 | 0.2368 |
Echinococcus multilocularis | ATP dependent DNA helicase PIF1 | 0.0031 | 0.1592 | 0.1792 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0389 | 0.0438 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0045 | 0.3632 | 0.4088 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0031 | 0.1592 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0024 | 0.0389 | 0.0438 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3632 | 0.4088 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0024 | 0.0389 | 0.0438 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0045 | 0.3632 | 0.4088 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.