Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | 0.0043 | 0.3641 | 0.4098 |
Brugia malayi | nuclear receptor NHR-88 | 0.0043 | 0.3641 | 0.4098 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.3641 | 0.4098 |
Brugia malayi | ecdysteroid receptor | 0.0043 | 0.3641 | 0.4098 |
Entamoeba histolytica | hypothetical protein, conserved | 0.003 | 0.1539 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0043 | 0.3641 | 0.3641 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0043 | 0.3641 | 0.4098 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0043 | 0.3641 | 0.4098 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0043 | 0.3641 | 0.4098 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0043 | 0.3641 | 0.4098 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0043 | 0.3641 | 0.4098 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0043 | 0.3641 | 0.4098 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0043 | 0.3641 | 0.4098 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0043 | 0.3641 | 0.4098 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0022 | 0.0265 | 0.0265 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0032 | 0.1892 | 0.2129 |
Onchocerca volvulus | 0.0043 | 0.3641 | 1 | |
Schistosoma mansoni | nuclear hormone receptor | 0.0043 | 0.3641 | 0.3641 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0043 | 0.3641 | 0.4098 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0043 | 0.3641 | 0.4098 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0043 | 0.3641 | 0.4098 |
Echinococcus granulosus | voltage gated potassium channel | 0.0022 | 0.0265 | 0.0298 |
Brugia malayi | steroid hormone receptor | 0.0043 | 0.3641 | 0.4098 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0043 | 0.3641 | 0.4098 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0032 | 0.1892 | 0.5 |
Giardia lamblia | Rrm3p helicase | 0.003 | 0.1539 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0043 | 0.3641 | 0.3641 |
Schistosoma mansoni | thyroid hormone receptor | 0.0043 | 0.3641 | 0.3641 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0043 | 0.3641 | 0.3641 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0043 | 0.3641 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0075 | 0.8885 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0043 | 0.3641 | 0.4098 |
Trypanosoma brucei | cytochrome P450, putative | 0.0032 | 0.1892 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0043 | 0.3641 | 0.4098 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.039 | 0.0439 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0043 | 0.3641 | 0.4098 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0023 | 0.039 | 0.039 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0043 | 0.3641 | 0.4098 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.3641 | 0.4098 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0043 | 0.3641 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0032 | 0.1892 | 0.2129 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0043 | 0.3641 | 0.3641 |
Brugia malayi | Cytochrome P450 family protein | 0.0033 | 0.2106 | 0.237 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0043 | 0.3641 | 0.4098 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0043 | 0.3641 | 0.4098 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0043 | 0.3641 | 0.4098 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0022 | 0.0265 | 0.0298 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0043 | 0.3641 | 0.3641 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.3641 | 0.4098 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0043 | 0.3641 | 0.4098 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0043 | 0.3641 | 0.4098 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0043 | 0.3641 | 0.4098 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0043 | 0.3641 | 0.4098 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0023 | 0.039 | 0.039 |
Brugia malayi | nuclear hormone receptor | 0.0043 | 0.3641 | 0.4098 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0023 | 0.039 | 0.0439 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0075 | 0.8885 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.007 | 0.8087 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0032 | 0.1892 | 0.2129 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0043 | 0.3641 | 0.4098 |
Brugia malayi | hypothetical protein | 0.0023 | 0.039 | 0.0439 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0043 | 0.3641 | 0.4098 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0022 | 0.0265 | 0.0298 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0043 | 0.3641 | 0.4098 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0023 | 0.039 | 0.0439 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0032 | 0.1892 | 0.2129 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0023 | 0.039 | 0.0439 |
Echinococcus granulosus | ATP dependent DNA helicase PIF1 | 0.003 | 0.1539 | 0.1733 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0032 | 0.1892 | 1 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.003 | 0.1539 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.039 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.039 | 0.0439 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0022 | 0.0265 | 0.0265 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0043 | 0.3641 | 0.3641 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.039 | 0.0439 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0043 | 0.3641 | 0.4098 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0043 | 0.3641 | 0.4098 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0075 | 0.8885 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0032 | 0.1892 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0043 | 0.3641 | 0.3641 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0043 | 0.3641 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0043 | 0.3641 | 0.4098 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0043 | 0.3641 | 0.4098 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.3641 | 0.4098 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0043 | 0.3641 | 0.4098 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0043 | 0.3641 | 0.4098 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0043 | 0.3641 | 0.4098 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0043 | 0.3641 | 0.4098 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0265 | 0.0298 |
Schistosoma mansoni | coup transcription factor | 0.0043 | 0.3641 | 0.3641 |
Schistosoma mansoni | thyroid hormone receptor | 0.0043 | 0.3641 | 0.3641 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.039 | 0.0439 |
Brugia malayi | Cytochrome P450 family protein | 0.0032 | 0.1892 | 0.2129 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0043 | 0.3641 | 0.3641 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0043 | 0.3641 | 0.3641 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0023 | 0.039 | 0.0439 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0043 | 0.3641 | 0.4098 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0043 | 0.3641 | 0.4098 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.3641 | 0.4098 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.3641 | 0.4098 |
Echinococcus multilocularis | ATP dependent DNA helicase PIF1 | 0.003 | 0.1539 | 0.1733 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0043 | 0.3641 | 0.4098 |
Leishmania major | cytochrome p450-like protein | 0.0032 | 0.1892 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0022 | 0.0265 | 0.0298 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0023 | 0.039 | 0.0439 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0033 | 0.2106 | 0.237 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.3641 | 0.4098 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0075 | 0.8885 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.3641 | 0.4098 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.007 | 0.8087 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0022 | 0.0265 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.7282 | 0.8196 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0043 | 0.3641 | 0.4098 |
Brugia malayi | hypothetical protein | 0.0023 | 0.039 | 0.0439 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0043 | 0.3641 | 0.4098 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.1539 | 0.1539 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0043 | 0.3641 | 0.4098 |
Brugia malayi | nuclear receptor RXR | 0.0023 | 0.039 | 0.0439 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0043 | 0.3641 | 0.4098 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.