Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | 0.0045 | 0.3632 | 0.4087 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0079 | 0.8886 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0045 | 0.3632 | 0.3632 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0045 | 0.3632 | 0.4087 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3632 | 0.4087 |
Brugia malayi | nuclear receptor NHR-88 | 0.0045 | 0.3632 | 0.4087 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0045 | 0.3632 | 0.4087 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3632 | 0.4087 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0045 | 0.3632 | 0.3632 |
Brugia malayi | ecdysteroid receptor | 0.0045 | 0.3632 | 0.4087 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0045 | 0.3632 | 0.4087 |
Leishmania major | cytochrome p450-like protein | 0.0034 | 0.1893 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3632 | 0.4087 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0389 | 0.0438 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0045 | 0.3632 | 0.4087 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0045 | 0.3632 | 0.4087 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0023 | 0.0271 | 0.0305 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0023 | 0.0271 | 0.0271 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0045 | 0.3632 | 0.4087 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0031 | 0.1546 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0045 | 0.3632 | 0.4087 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0045 | 0.3632 | 0.4087 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0034 | 0.1893 | 0.213 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0024 | 0.0389 | 0.0438 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0389 | 0.0438 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0045 | 0.3632 | 0.3632 |
Echinococcus granulosus | FTZ F1 alpha | 0.0045 | 0.3632 | 0.4087 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0045 | 0.3632 | 0.4087 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0034 | 0.1893 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0389 | 0.0438 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3632 | 0.4087 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0045 | 0.3632 | 0.4087 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0045 | 0.3632 | 0.3632 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0045 | 0.3632 | 0.3632 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0031 | 0.1546 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1546 | 0.1546 |
Brugia malayi | steroid hormone receptor | 0.0045 | 0.3632 | 0.4087 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0045 | 0.3632 | 0.4087 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0023 | 0.0271 | 0.0305 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0079 | 0.8886 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0045 | 0.3632 | 0.4087 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0024 | 0.0389 | 0.0438 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0074 | 0.8088 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0045 | 0.3632 | 0.4087 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0045 | 0.3632 | 0.4087 |
Brugia malayi | Cytochrome P450 family protein | 0.0034 | 0.1893 | 0.213 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0045 | 0.3632 | 0.3632 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0045 | 0.3632 | 0.4087 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0024 | 0.0389 | 0.0438 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0045 | 0.3632 | 0.4087 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0045 | 0.3632 | 0.4087 |
Brugia malayi | Cytochrome P450 family protein | 0.0035 | 0.2105 | 0.2369 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0045 | 0.3632 | 0.3632 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0045 | 0.3632 | 0.4087 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0045 | 0.3632 | 0.4087 |
Schistosoma mansoni | nuclear hormone receptor | 0.0045 | 0.3632 | 0.3632 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0034 | 0.1893 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0271 | 0.0305 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0045 | 0.3632 | 0.4087 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0024 | 0.0389 | 0.0389 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0045 | 0.3632 | 0.4087 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0045 | 0.3632 | 0.4087 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0389 | 0.0438 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0045 | 0.3632 | 0.3632 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3632 | 0.4087 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0045 | 0.3632 | 0.4087 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0389 | 0.0438 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0045 | 0.3632 | 0.4087 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0045 | 0.3632 | 0.4087 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0045 | 0.3632 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0023 | 0.0271 | 0.0305 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0045 | 0.3632 | 0.3632 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0045 | 0.3632 | 0.4087 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3632 | 0.4087 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0079 | 0.8886 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0074 | 0.8088 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0045 | 0.3632 | 0.4087 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0045 | 0.3632 | 0.4087 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0045 | 0.3632 | 0.4087 |
Brugia malayi | Cytochrome P450 family protein | 0.0034 | 0.1893 | 0.213 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0034 | 0.1893 | 0.213 |
Echinococcus granulosus | voltage gated potassium channel | 0.0023 | 0.0271 | 0.0305 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0389 | 0.0438 |
Echinococcus granulosus | ATP dependent DNA helicase PIF1 | 0.0031 | 0.1546 | 0.174 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0034 | 0.1893 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0024 | 0.0389 | 0.0438 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0023 | 0.0271 | 0.0305 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3632 | 0.4087 |
Onchocerca volvulus | 0.0045 | 0.3632 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3632 | 0.4087 |
Schistosoma mansoni | coup transcription factor | 0.0045 | 0.3632 | 0.3632 |
Brugia malayi | nuclear hormone receptor | 0.0045 | 0.3632 | 0.4087 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0045 | 0.3632 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0024 | 0.0389 | 0.0438 |
Schistosoma mansoni | thyroid hormone receptor | 0.0045 | 0.3632 | 0.3632 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0045 | 0.3632 | 0.4087 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0024 | 0.0389 | 0.0438 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0023 | 0.0271 | 0.0271 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0045 | 0.3632 | 0.4087 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0079 | 0.8886 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0034 | 0.1893 | 0.213 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0024 | 0.0389 | 0.0389 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0045 | 0.3632 | 0.4087 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0035 | 0.2105 | 0.2369 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0045 | 0.3632 | 0.4087 |
Trypanosoma brucei | cytochrome P450, putative | 0.0034 | 0.1893 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0045 | 0.3632 | 0.4087 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0389 | 0.0438 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0045 | 0.3632 | 0.4087 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0045 | 0.3632 | 0.4087 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0045 | 0.3632 | 0.3632 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0045 | 0.3632 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0045 | 0.3632 | 0.4087 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0045 | 0.3632 | 0.4087 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.7284 | 0.8197 |
Echinococcus multilocularis | ATP dependent DNA helicase PIF1 | 0.0031 | 0.1546 | 0.174 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0045 | 0.3632 | 0.4087 |
Giardia lamblia | Rrm3p helicase | 0.0031 | 0.1546 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0045 | 0.3632 | 0.4087 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.