Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 5 (sodium/glucose cotransporter), member 2 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 5 (sodium/glucose cotransporter), member 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.5462 | 0.5462 |
Brugia malayi | Histone deacetylase 1 | 0.0173 | 0.2966 | 0.2966 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.2966 | 0.2966 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0173 | 0.2966 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0173 | 0.2966 | 0.5 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0173 | 0.2966 | 0.2966 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0173 | 0.2966 | 0.5 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0363 | 0.9922 | 0.9922 |
Schistosoma mansoni | inositol transporter | 0.0363 | 0.9922 | 0.9922 |
Trypanosoma brucei | histone deacetylase 1 | 0.0173 | 0.2966 | 0.2062 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0173 | 0.2966 | 0.2966 |
Echinococcus granulosus | histone deacetylase 3 | 0.0173 | 0.2966 | 0.2966 |
Echinococcus multilocularis | solute carrier family 5 | 0.0363 | 0.9922 | 0.9922 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0124 | 0.1139 | 0.1139 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0124 | 0.1139 | 0.1139 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0173 | 0.2966 | 0.2062 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0173 | 0.2966 | 0.2966 |
Brugia malayi | histone deacetylase 11 | 0.0124 | 0.1139 | 0.1139 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0173 | 0.2966 | 0.2062 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0124 | 0.1139 | 0.1139 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0124 | 0.1139 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.1139 | 0.1139 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0363 | 0.9922 | 0.9922 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0124 | 0.1139 | 0.1139 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0173 | 0.2966 | 0.2966 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0173 | 0.2966 | 0.2966 |
Echinococcus granulosus | histone deacetylase 8 | 0.0124 | 0.1139 | 0.1139 |
Schistosoma mansoni | inositol transporter | 0.0363 | 0.9922 | 0.9922 |
Schistosoma mansoni | histone deacetylase | 0.0173 | 0.2966 | 0.2966 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0173 | 0.2966 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.5462 | 0.5462 |
Echinococcus granulosus | solute carrier family 5 | 0.0363 | 0.9922 | 0.9922 |
Giardia lamblia | Histone deacetylase | 0.0173 | 0.2966 | 0.5 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0363 | 0.9922 | 0.9922 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0173 | 0.2966 | 0.2966 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0173 | 0.2966 | 0.2062 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0173 | 0.2966 | 0.5 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0363 | 0.9922 | 0.9922 |
Echinococcus granulosus | histone deacetylase 1 | 0.0173 | 0.2966 | 0.2966 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0173 | 0.2966 | 0.5 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0363 | 0.9922 | 0.9922 |
Entamoeba histolytica | histone deacetylase, putative | 0.0173 | 0.2966 | 0.5 |
Schistosoma mansoni | histone deacetylase | 0.0173 | 0.2966 | 0.2966 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0173 | 0.2966 | 0.2966 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0124 | 0.1139 | 0.1139 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0173 | 0.2966 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0173 | 0.2966 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0173 | 0.2966 | 0.5 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0124 | 0.1139 | 0.1139 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0173 | 0.2966 | 0.2966 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.37 uM | Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillation counting | ChEMBL. | 21398124 |
IC50 (binding) | = 4.75 uM | Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside transport after 60 mins by scintillation counting | ChEMBL. | 21398124 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.