TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 421.257 | Formula: C17H10Cl2N4O3S
H donors: 2 H acceptors: 3 LogP: 3.96 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc(cc1)N1/C(=N/N=C/2\C(=O)Nc3c2c(Cl)ccc3Cl)/SCC1=O
InChi: 1S/C17H10Cl2N4O3S/c18-10-5-6-11(19)14-13(10)15(16(26)20-14)21-22-17-23(12(25)7-27-17)8-1-3-9(24)4-2-8/h1-6,24H,7H2,(H,20,21,26)/b22-17-
InChiKey: UVHYRSUPFZPFPC-XLNRJJMWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	multiple ankyrin repeats single kh domain protein, putative	0.0004	0.0063	0.0462
Giardia lamblia	Kinase, NEK-frag	0.0004	0.0063	0.0001
Trypanosoma cruzi	palmitoyl acyltransferase 1, putative	0.0004	0.0077	0.0109
Trichomonas vaginalis	ankyrin, putative	0.0004	0.0064	0.0472
Entamoeba histolytica	hypothetical protein	0.004	0.1363	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0063	0.00000010649
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0064	0.0472
Trichomonas vaginalis	ankyrin repeat domain-containing protein, putative	0.0004	0.0064	0.0472
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Brugia malayi	coiled-coil like protein 1	0.0025	0.0816	0.0822
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0063	0.00000010649
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0025	0.0816	0.5796
Entamoeba histolytica	hypothetical protein	0.004	0.1363	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0064	0.0472
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0006	0.0124	0.091
Trichomonas vaginalis	fetal globin-inducing factor, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	nf kappa B inhibitor I-kappa-B, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin, putative	0.0004	0.0077	0.0565
Trypanosoma brucei	palmitoyl acyltransferase 1, putative	0.0004	0.0077	0.0109
Trichomonas vaginalis	ion channel nompc, putative	0.0004	0.0077	0.0565
Giardia lamblia	Kinase, NEK	0.0004	0.0063	0.0001
Entamoeba histolytica	hypothetical protein	0.004	0.1363	1
Echinococcus multilocularis	Ankyrin	0.0004	0.0063	0.0062
Trichomonas vaginalis	ankyrin, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0816	0.599
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin, putative	0.0004	0.0079	0.0576
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.1363	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.1363	1
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0004	0.0063	0.0462
Entamoeba histolytica	zinc finger protein, putative	0.004	0.1363	1
Echinococcus multilocularis	26S proteasome non ATPase regulatory subunit 10	0.0004	0.0064	0.0063
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0077	0.0565
Giardia lamblia	Protein 21.1	0.0004	0.0063	0.0001
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.004	0.1363	1
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0004	0.0064	0.0472
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Brugia malayi	Neurabin protein 1	0.0025	0.0816	0.0822
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0064	0.0472
Schistosoma mansoni	phospholipase	0.0004	0.0063	0.000000096934
Brugia malayi	Patatin-like phospholipase family protein	0.0004	0.0063	0.0062
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Trichomonas vaginalis	tankyrase, putative	0.0002	0.0001	0.0011
Schistosoma mansoni	lip-related protein (liprin) alpha	0.0025	0.0816	0.0758
Trichomonas vaginalis	tankyrase, putative	0.0004	0.0064	0.0472
Brugia malayi	glutaminase DH11.1	0.0004	0.0063	0.0062
Giardia lamblia	Ankyrin 1	0.0004	0.0063	0.0001
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0077	0.0565
Onchocerca volvulus		0.0025	0.0816	0.0847
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0004	0.0077	0.0565
Echinococcus granulosus	liprin alpha 2	0.0025	0.0816	0.0759
Echinococcus multilocularis	SAM domain containing protein	0.0025	0.0816	0.0816
Echinococcus multilocularis	Ankyrin	0.0004	0.0079	0.0077
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0064	0.0472
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0001	0.0011
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Trypanosoma cruzi	palmitoyl acyltransferase 1, putative	0.0004	0.0077	0.0109
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Trichomonas vaginalis	protein phosphatase 1 regulatory subunit 12C, putative	0.0004	0.0077	0.0565
Echinococcus granulosus	stromal interaction molecule 1	0.0025	0.0816	0.0759
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0002	0.0001	0.0011
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Brugia malayi	sterile alpha and TIR motif containing protein 1 isoform a	0.0025	0.0816	0.0822
Trichomonas vaginalis	E3 ubiquitin protein ligase, putative	0.0004	0.0064	0.0472
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0002	0.0001	0.0011
Echinococcus multilocularis	sterile alpha and tir motif containing protein	0.0025	0.0816	0.0816
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.004	0.1363	0.1308
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0077	0.0565
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Echinococcus multilocularis	liprin beta 1	0.0025	0.0816	0.0816
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Giardia lamblia	Kinase, NEK	0.0004	0.0077	1
Trichomonas vaginalis	fibronectin type 3 and ankyrin repeat domains, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.1363	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin repeat-rich membrane-spanning protein, putative	0.0004	0.0063	0.0462
Echinococcus granulosus	Ankyrin	0.0004	0.0063	0.000000097072
Trichomonas vaginalis	TKL family protein kinase	0.0004	0.0063	0.0462
Entamoeba histolytica	hypothetical protein	0.004	0.1363	1
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.1363	1
Trichomonas vaginalis	unc-44 ankyrins, putative	0.0004	0.0077	0.0565
Trichomonas vaginalis	serine/threonine-protein kinase ripk4, putative	0.0004	0.0064	0.0472
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0077	0.0565
Trichomonas vaginalis	unc-44 ankyrins, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0077	0.0565
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0025	0.0816	0.5
Brugia malayi	Uncoordinated protein 44	0.0004	0.0064	0.0063
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin repeat-rich membrane-spanning protein, putative	0.0004	0.0064	0.0472
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.1363	1
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0064	0.0472
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Trichomonas vaginalis	serine/threonine-protein kinase ripk4, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0816	0.599
Entamoeba histolytica	ankyrin repeat protein, putative	0.0004	0.0063	0.0000007409
Plasmodium falciparum	tyrosine kinase-like protein	0.0025	0.0816	0.5
Schistosoma mansoni	hypothetical protein	0.0025	0.0816	0.0758
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0064	0.0472
Schistosoma mansoni	26S proteasome subunit	0.0004	0.0063	0.000000096934
Schistosoma mansoni	lar interacting protein (lip)-related protein	0.0025	0.0816	0.0758
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0816	0.0833
Trichomonas vaginalis	sex-determining protein fem-1, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0006	0.0123	0.0899
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Trichomonas vaginalis	2-5A-dependent ribonuclease, putative	0.0004	0.0077	0.0565
Giardia lamblia	Protein 21.1	0.0004	0.0063	0.0001
Trichomonas vaginalis	ion channel nompc, putative	0.0004	0.0064	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0816	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0816	0.0833
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.004	0.1363	0.1308
Echinococcus multilocularis	stromal interaction molecule 1	0.0025	0.0816	0.0816
Trichomonas vaginalis	protein phosphatase 1 regulatory subunit 12B, putative	0.0004	0.0063	0.0462
Echinococcus granulosus	poly adp ribose polymerase 2	0.004	0.1363	0.131
Trichomonas vaginalis	ion channel nompc, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0816	0.0833
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0002	0.0001	0.0011
Brugia malayi	hypothetical protein	0.0025	0.0816	0.0822
Echinococcus multilocularis	tankyrase	0.0282	0.9986	1
Trichomonas vaginalis	centaurin beta, putative	0.0004	0.0063	0.0462
Echinococcus granulosus	SAM domain containing protein	0.0025	0.0816	0.0759
Echinococcus granulosus	Sterile alpha motif SAM	0.0025	0.0816	0.0759
Trichomonas vaginalis	26S proteasome non-ATPase regulatory subunit, putative	0.0004	0.0063	0.0462
Brugia malayi	WGR domain containing protein	0.004	0.1363	0.1373
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0816	0.599
Echinococcus granulosus	poly ADP ribose polymerase 1	0.004	0.1363	0.131
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Echinococcus multilocularis	ankyrin repeat domain containing protein 6	0.0004	0.0063	0.0062
Trichomonas vaginalis	hypothetical protein	0.0004	0.0063	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0213	0.7535	0.826
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	serine/threonine-protein kinase ripk4, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin repeat and sam domain-containing protein, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Brugia malayi	Leucine Rich Repeat family protein	0.0004	0.0063	0.0062
Loa Loa (eye worm)	Notch2	0.0004	0.0064	0.0002
Echinococcus granulosus	liprin beta 1	0.0025	0.0816	0.0759
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Brugia malayi	Liprin-alpha 2	0.0025	0.0816	0.0822
Schistosoma mansoni	hypothetical protein	0.0025	0.0816	0.0758
Onchocerca volvulus		0.0025	0.0816	0.0847
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0079	0.0576
Plasmodium falciparum	protein kinase, putative	0.0025	0.0816	0.5
Echinococcus granulosus	sterile alpha and tir motif containing protein	0.0025	0.0816	0.0759
Trichomonas vaginalis	fetal globin-inducing factor, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0004	0.0063	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0063	0.00000010649
Echinococcus multilocularis	E3 ubiquitin protein ligase mib1	0.0004	0.0077	0.0076
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0002	0.0001	0.0011
Trichomonas vaginalis	ankyrin, putative	0.0004	0.0064	0.0472
Echinococcus granulosus	26S proteasome non ATPase regulatory subunit 10	0.0004	0.0064	0.0001
Trichomonas vaginalis	protein phosphatase 1 regulatory subunit 12B, putative	0.0004	0.0064	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0079	0.0017
Trypanosoma brucei	poly(adp-ribose) polymerase	0.004	0.1363	1
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0004	0.0077	0.0565
Trichomonas vaginalis	2-5A-dependent ribonuclease, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	cortactin-binding protein, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	multiple ankyrin repeats single kh domain protein, putative	0.0004	0.0077	0.0565
Trichomonas vaginalis	sex-determining protein fem-1, putative	0.0004	0.0063	0.0462
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.004	0.1363	0.1364
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Trichomonas vaginalis	c2h2 zinc finger protein, putative	0.0025	0.0816	0.599
Trichomonas vaginalis	ion channel nompc, putative	0.0004	0.0064	0.0472
Trypanosoma cruzi	ankyrin repeat protein, putative	0.0004	0.0063	0.0000007409
Giardia lamblia	Kinase, NEK	0.0004	0.0063	0.0001
Schistosoma mansoni	sarm1	0.0025	0.0816	0.0758
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0816	0.0833
Onchocerca volvulus	Tankyrase homolog	0.0253	0.8957	1
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.1363	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Leishmania major	huntingtin interacting protein (HIP), putative	0.0004	0.0077	1
Schistosoma mansoni	hypothetical protein	0.0025	0.0816	0.0758
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0004	0.0077	0.0565
Echinococcus multilocularis	liprin alpha 2	0.0025	0.0816	0.0816
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.1363	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.004	0.1363	1
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.1363	1
Brugia malayi	Tnks protein	0.028	0.9921	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0001	0.0011
Loa Loa (eye worm)	toll and interleukin 1 receptor domain-containing protein isoform f	0.0025	0.0816	0.0833
Echinococcus granulosus	tankyrase	0.0282	0.9986	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.1363	0.1437
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0002	0.0001	0.0011
Loa Loa (eye worm)	tnks protein	0.0257	0.9108	1
Trichomonas vaginalis	unc-44 ankyrins, putative	0.0004	0.0077	0.0565
Trichomonas vaginalis	homeobox-containing protein wariai, putative	0.0004	0.0063	0.0462
Brugia malayi	hypothetical protein	0.0025	0.0816	0.0822
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0064	0.0472
Trichomonas vaginalis	ankyrin, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	cask-interacting protein (caskin) 1,2, putative	0.0004	0.0063	0.0462
Schistosoma mansoni	ga binding protein beta chain (transcription factor e4tf1-47)	0.0004	0.0063	0.000000096934
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.004	0.1363	0.1437
Trichomonas vaginalis	hypothetical protein	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.004	0.1363	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0077	0.0565
Trichomonas vaginalis	mind bomb, putative	0.0004	0.0063	0.0462
Schistosoma mansoni	hypothetical protein	0.0025	0.0816	0.0758
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0063	0.0462
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.004	0.1363	1
Schistosoma mansoni	ankyrin 23/unc44	0.0004	0.0077	0.0014
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Giardia lamblia	Kinase, NEK	0.0004	0.0077	1
Echinococcus granulosus	E3 ubiquitin protein ligase mib1	0.0004	0.0077	0.0014
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Echinococcus granulosus	Ankyrin	0.0004	0.0077	0.0014
Echinococcus multilocularis	Ankyrin	0.0004	0.0063	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0063	0.00000010649
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0063	0.0462
Brugia malayi	Patatin-like phospholipase family protein	0.0004	0.0077	0.0076
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0004	0.0077	0.0565
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.004	0.1363	0.1364
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0004	0.0077	0.0565
Trichomonas vaginalis	2-5A-dependent ribonuclease, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	inversin, putative	0.0004	0.0064	0.0472
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0816	0.599
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0006	0.0138	0.1014
Trypanosoma brucei	Ankyrin repeats (many copies), putative	0.0004	0.0063	0.0000007409
Trichomonas vaginalis	rolling pebbles, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	ion channel nompc, putative	0.0004	0.0063	0.0462
Echinococcus multilocularis	poly (ADP ribose) polymerase	0.004	0.1363	0.1364
Brugia malayi	WGR domain containing protein	0.004	0.1363	0.1373
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0004	0.0063	0.0462
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.1363	1
Trichomonas vaginalis	ankyrin repeat-cotaining protein, putative	0.0004	0.0063	0.0462

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 10 %	Competitive inhibition of recombinant TAK1-TAB1 assessed as [33P]gamma-ATP incorporation into substrate histone H1 peptide at 10 uM by filter plate assay	ChEMBL.	21316225

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1761724

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1511119