Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0737 | 0.2711 | 1 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0321 | 0.1101 | 0.1101 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0028 | 0.0018 |
Mycobacterium tuberculosis | Probable 3-hydroxyacyl-thioester dehydratase HtdY | 0.0085 | 0.0186 | 0.0652 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0043 | 0.0024 | 0.0053 |
Loa Loa (eye worm) | short chain dehydrogenase/reductase family oxidoreductase | 0.0043 | 0.0024 | 0.0024 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0123 | 0.0335 | 0.0325 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0737 | 0.2711 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0028 | 0.0018 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0123 | 0.0335 | 0.0335 |
Schistosoma mansoni | amidase | 0.0324 | 0.1113 | 0.1104 |
Brugia malayi | bHLH-PAS transcription factor | 0.0077 | 0.0156 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0043 | 0.0043 |
Mycobacterium ulcerans | dehydratase | 0.0085 | 0.0186 | 0.0652 |
Loa Loa (eye worm) | hypothetical protein | 0.0348 | 0.1206 | 0.1206 |
Brugia malayi | PAS domain containing protein | 0.0104 | 0.026 | 0.026 |
Entamoeba histolytica | hypothetical protein | 0.0737 | 0.2711 | 0.5 |
Brugia malayi | hypoxia-induced factor 1 | 0.0321 | 0.1101 | 0.1101 |
Brugia malayi | Amidase family protein | 0.0039 | 0.001 | 0.001 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0123 | 0.0335 | 0.0335 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0028 | 0.0018 |
Mycobacterium tuberculosis | Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. | 0.0085 | 0.0186 | 0.0652 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0737 | 0.2711 | 1 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0737 | 0.2711 | 1 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0737 | 0.2711 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0123 | 0.0335 | 0.0325 |
Trypanosoma cruzi | amidase, putative | 0.0039 | 0.001 | 0.5 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0104 | 0.026 | 0.025 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0077 | 0.0156 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0186 | 0.0186 |
Brugia malayi | putative amidase | 0.0039 | 0.001 | 0.001 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0737 | 0.2711 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0335 | 0.0335 |
Schistosoma mansoni | single-minded | 0.0104 | 0.026 | 0.025 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0123 | 0.0335 | 0.0325 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0043 | 0.0043 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0043 | 0.0024 | 0.0024 |
Brugia malayi | amidase | 0.0324 | 0.1113 | 0.1113 |
Schistosoma mansoni | hypothetical protein | 0.0099 | 0.024 | 0.0231 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0028 | 0.0018 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0043 | 0.0043 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0737 | 0.2711 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0028 | 0.0018 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0737 | 0.2711 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0028 | 0.0028 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0043 | 0.0024 | 0.0053 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0737 | 0.2711 | 1 |
Brugia malayi | Amidase family protein | 0.0039 | 0.001 | 0.001 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0043 | 0.0043 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0123 | 0.0335 | 0.0325 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0324 | 0.1113 | 0.1104 |
Trypanosoma cruzi | amidase, putative | 0.0039 | 0.001 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0324 | 0.1113 | 0.1104 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0028 | 0.0018 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0324 | 0.1113 | 0.1104 |
Echinococcus granulosus | FTZ F1 alpha | 0.0489 | 0.175 | 0.1741 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0028 | 0.0018 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0043 | 0.0024 | 0.0053 |
Brugia malayi | maoC like domain containing protein | 0.0085 | 0.0186 | 0.0186 |
Loa Loa (eye worm) | amidase | 0.0039 | 0.001 | 0.001 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0737 | 0.2711 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0028 | 0.0028 |
Onchocerca volvulus | 0.0077 | 0.0156 | 0.0156 | |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0737 | 0.2711 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0324 | 0.1113 | 0.1104 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0324 | 0.1113 | 0.1104 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.1113 | 0.1113 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0737 | 0.2711 | 1 |
Mycobacterium ulcerans | putative regulatory protein | 0.0077 | 0.0156 | 0.054 |
Loa Loa (eye worm) | amidase | 0.0039 | 0.001 | 0.001 |
Mycobacterium ulcerans | hypothetical protein | 0.0085 | 0.0186 | 0.0652 |
Mycobacterium leprae | conserved hypothetical protein | 0.0737 | 0.2711 | 1 |
Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0076 | 0.0153 | 0.0358 |
Brugia malayi | hypothetical protein | 0.0348 | 0.1206 | 0.1206 |
Echinococcus granulosus | single minded 2 | 0.0077 | 0.0156 | 0.0146 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
pEC50 (functional) | Agonist activity at human SF-1 assessed as DAX1 1-23 peptide recruitment by TR-FRET assay relative to control | ChEMBL. | 21391689 | |
pEC50 (functional) | Agonist activity at human LRH-1 receptor assessed as TIF2 737-757 peptide recruitment by TR-FRET assay relative to control | ChEMBL. | 21391689 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.