Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 8B | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | plexin | 0.0023 | 0.0196 | 0.0633 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0518 | 0.0518 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0022 | 0.0144 | 0.0465 |
Echinococcus granulosus | roundabout 2 | 0.0034 | 0.0518 | 0.5671 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0144 | 0.0144 |
Echinococcus multilocularis | neuroglian | 0.0027 | 0.0308 | 0.3376 |
Brugia malayi | plexin A | 0.0048 | 0.0913 | 0.0913 |
Echinococcus granulosus | neuroglian | 0.0027 | 0.0308 | 0.3376 |
Brugia malayi | Plexin repeat family protein | 0.004 | 0.0694 | 0.0694 |
Schistosoma mansoni | vesicular amine transporter | 0.0022 | 0.0144 | 0.0465 |
Schistosoma mansoni | plexin | 0.004 | 0.0694 | 0.2243 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.2828 | 0.2828 |
Echinococcus granulosus | twitchin | 0.0027 | 0.0308 | 0.3376 |
Echinococcus multilocularis | Immunoglobulin | 0.0022 | 0.0144 | 0.1579 |
Echinococcus multilocularis | Immunoglobulin | 0.0022 | 0.0144 | 0.1579 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0022 | 0.0144 | 0.0465 |
Loa Loa (eye worm) | plexin A | 0.0048 | 0.0913 | 0.0913 |
Onchocerca volvulus | 0.0322 | 0.9031 | 0.9698 | |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.2828 | 0.2828 |
Loa Loa (eye worm) | calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase | 0.0121 | 0.3096 | 0.3096 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.3096 | 0.3096 |
Onchocerca volvulus | 0.004 | 0.0694 | 0.0746 | |
Echinococcus granulosus | defective proboscis extension response | 0.0022 | 0.0144 | 0.1579 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0196 | 0.0633 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0694 | 0.0694 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.2828 | 0.2828 |
Echinococcus granulosus | plexin a4 | 0.0048 | 0.0913 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0144 | 0.0144 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0354 | 0.0354 |
Echinococcus multilocularis | plexin a4 | 0.0048 | 0.0913 | 1 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0144 | 0.0144 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0518 | 0.0518 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0144 | 0.0144 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0144 | 0.0144 |
Schistosoma mansoni | camp-specific cyclic nucleotide phosphodiesterase | 0.0121 | 0.3096 | 1 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0022 | 0.0144 | 0.0144 |
Schistosoma mansoni | cell adhesion molecule | 0.0029 | 0.0354 | 0.1142 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0022 | 0.0144 | 0.1579 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0022 | 0.0144 | 0.0144 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.0121 | 0.3096 | 0.3096 |
Echinococcus granulosus | Immunoglobulin | 0.0022 | 0.0144 | 0.1579 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0029 | 0.0354 | 0.3873 |
Echinococcus multilocularis | roundabout 2 | 0.0034 | 0.0518 | 0.5671 |
Schistosoma mansoni | nephrin | 0.0027 | 0.0308 | 0.0995 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0144 | 0.0144 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0144 | 0.0144 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0331 | 0.9312 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0196 | 0.0196 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10000 nM | Inhibition of PDE8B | ChEMBL. | 21459572 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.