Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 8B | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase | 0.0121 | 0.6944 | 0.6944 |
Schistosoma mansoni | camp-specific cyclic nucleotide phosphodiesterase | 0.0121 | 0.6944 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.6383 | 0.6383 |
Onchocerca volvulus | 0.0155 | 0.9026 | 0.9674 | |
Echinococcus granulosus | plexin a4 | 0.0023 | 0.0859 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.6383 | 0.6383 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0639 | 0.0639 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0138 | 0.0138 |
Echinococcus granulosus | defective proboscis extension response | 0.001 | 0.0086 | 0.0999 |
Brugia malayi | Plexin repeat family protein | 0.0019 | 0.0639 | 0.0639 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.001 | 0.0086 | 0.0124 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.6944 | 0.6944 |
Echinococcus multilocularis | Immunoglobulin | 0.001 | 0.0086 | 0.0999 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0086 | 0.0086 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.001 | 0.0086 | 0.0086 |
Echinococcus multilocularis | roundabout 2 | 0.0017 | 0.0462 | 0.5373 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0014 | 0.0296 | 0.3452 |
Loa Loa (eye worm) | plexin A | 0.0023 | 0.0859 | 0.0859 |
Echinococcus multilocularis | Immunoglobulin | 0.001 | 0.0086 | 0.0999 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.001 | 0.0086 | 0.0124 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0159 | 0.9308 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0086 | 0.0086 |
Echinococcus granulosus | neuroglian | 0.0013 | 0.0251 | 0.292 |
Schistosoma mansoni | cell adhesion molecule | 0.0014 | 0.0296 | 0.0427 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0296 | 0.0296 |
Echinococcus granulosus | Immunoglobulin | 0.001 | 0.0086 | 0.0999 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.0121 | 0.6944 | 0.6944 |
Schistosoma mansoni | vesicular amine transporter | 0.001 | 0.0086 | 0.0124 |
Echinococcus granulosus | twitchin | 0.0013 | 0.0251 | 0.292 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0086 | 0.0086 |
Echinococcus granulosus | roundabout 2 | 0.0017 | 0.0462 | 0.5373 |
Schistosoma mansoni | plexin | 0.0011 | 0.0138 | 0.0199 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0138 | 0.0199 |
Echinococcus multilocularis | plexin a4 | 0.0023 | 0.0859 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0462 | 0.0462 |
Schistosoma mansoni | nephrin | 0.0013 | 0.0251 | 0.0361 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.6383 | 0.6383 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.001 | 0.0086 | 0.0999 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0462 | 0.0462 |
Schistosoma mansoni | plexin | 0.0019 | 0.0639 | 0.0921 |
Echinococcus multilocularis | neuroglian | 0.0013 | 0.0251 | 0.292 |
Brugia malayi | plexin A | 0.0023 | 0.0859 | 0.0859 |
Brugia malayi | hypothetical protein | 0.001 | 0.0086 | 0.0086 |
Brugia malayi | Fibronectin type III domain containing protein | 0.001 | 0.0086 | 0.0086 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1700 nM | Inhibition of PDE8B | ChEMBL. | 21459572 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.