Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 8B | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0025 | 0.0224 | 0.2586 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0093 | 0.0093 |
Schistosoma mansoni | vesicular amine transporter | 0.0021 | 0.0093 | 0.0135 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0025 | 0.0224 | 1 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.0025 | 0.0224 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0224 | 0.0224 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0025 | 0.0224 | 1 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0021 | 0.0093 | 0.0135 |
Echinococcus multilocularis | plexin a4 | 0.0046 | 0.0865 | 1 |
Echinococcus granulosus | neuroglian | 0.0027 | 0.0258 | 0.2977 |
Brugia malayi | Plexin repeat family protein | 0.0039 | 0.0646 | 0.0646 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0224 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0093 | 0.0093 |
Echinococcus granulosus | defective proboscis extension response | 0.0021 | 0.0093 | 0.1071 |
Schistosoma mansoni | plexin | 0.0023 | 0.0145 | 0.0211 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0224 | 1 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0025 | 0.0224 | 0.2586 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0025 | 0.0224 | 0.0327 |
Echinococcus multilocularis | Immunoglobulin | 0.0021 | 0.0093 | 0.1071 |
Echinococcus granulosus | plexin a4 | 0.0046 | 0.0865 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.6853 | 0.6853 |
Echinococcus granulosus | Immunoglobulin | 0.0021 | 0.0093 | 0.1071 |
Leishmania major | protein kinase, putative | 0.0025 | 0.0224 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0224 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0093 | 0.0093 |
Echinococcus multilocularis | roundabout 2 | 0.0033 | 0.0468 | 0.541 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0025 | 0.0224 | 1 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0028 | 0.0303 | 0.3504 |
Schistosoma mansoni | nephrin | 0.0027 | 0.0258 | 0.0376 |
Schistosoma mansoni | single-minded | 0.0025 | 0.0224 | 0.0327 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.0224 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0323 | 0.9309 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.0021 | 0.0093 | 0.1071 |
Loa Loa (eye worm) | plexin A | 0.0046 | 0.0865 | 0.0865 |
Schistosoma mansoni | cell adhesion molecule | 0.0028 | 0.0303 | 0.0443 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0025 | 0.0224 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0468 | 0.0468 |
Brugia malayi | PAS domain containing protein | 0.0025 | 0.0224 | 0.0224 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0021 | 0.0093 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0093 | 0.0093 |
Echinococcus granulosus | roundabout 2 | 0.0033 | 0.0468 | 0.541 |
Brugia malayi | plexin A | 0.0046 | 0.0865 | 0.0865 |
Echinococcus multilocularis | neuroglian | 0.0027 | 0.0258 | 0.2977 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0021 | 0.0093 | 0.0135 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0025 | 0.0224 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0468 | 0.0468 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0093 | 0.0093 |
Chlamydia trachomatis | two component regulatory system sensor histidine kinase | 0.0025 | 0.0224 | 0.5 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0025 | 0.0224 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0021 | 0.0093 | 0.0093 |
Leishmania major | PAS-domain containing phosphoglycerate kinase, putative | 0.0025 | 0.0224 | 1 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.0025 | 0.0224 | 1 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0025 | 0.0224 | 1 |
Onchocerca volvulus | 0.0039 | 0.0646 | 0.0465 | |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.0025 | 0.0224 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.6299 | 0.6299 |
Echinococcus granulosus | twitchin | 0.0027 | 0.0258 | 0.2977 |
Schistosoma mansoni | plexin | 0.0039 | 0.0646 | 0.0942 |
Echinococcus multilocularis | Aryl hydrocarbon receptor nuclear | 0.0025 | 0.0224 | 0.2586 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0646 | 0.0646 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.6299 | 0.6299 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.0025 | 0.0224 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0093 | 0.0093 |
Onchocerca volvulus | 0.0314 | 0.9026 | 0.9689 | |
Echinococcus granulosus | Aryl hydrocarbon receptor nuclear | 0.0025 | 0.0224 | 0.2586 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.6299 | 0.6299 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.0243 | 0.6853 | 0.6853 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0145 | 0.0145 |
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.0025 | 0.0224 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0303 | 0.0303 |
Loa Loa (eye worm) | calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase | 0.0243 | 0.6853 | 0.6853 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0021 | 0.0093 | 0.0093 |
Mycobacterium leprae | Possible regulatory protein | 0.0025 | 0.0224 | 0.5 |
Trichomonas vaginalis | adenylate cyclase, type VII, putative | 0.0025 | 0.0224 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0093 | 0.0093 |
Trichomonas vaginalis | soluble guanylate cyclase gcy, putative | 0.0025 | 0.0224 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0145 | 0.0211 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.0025 | 0.0224 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0224 | 0.0224 |
Schistosoma mansoni | camp-specific cyclic nucleotide phosphodiesterase | 0.0243 | 0.6853 | 1 |
Leishmania major | protein kinase, putative | 0.0025 | 0.0224 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 40 nM | Inhibition of PDE8B | ChEMBL. | 21459572 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.