Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | ATP-binding cassette protein subfamily G | 0.0036 | 0.0834 | 0.0275 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2074 | 0.2489 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0706 | 0.0847 |
Toxoplasma gondii | ATP-binding cassette G family transporter ABCG87 | 0.0036 | 0.0834 | 0.0275 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0033 | 0.0706 | 0.014 |
Mycobacterium tuberculosis | Probable conserved transmembrane ATP-binding protein ABC transporter | 0.0182 | 0.8206 | 1 |
Brugia malayi | ABC transporter family protein | 0.0184 | 0.8334 | 1 |
Schistosoma mansoni | ABC transporter | 0.0033 | 0.0706 | 0.0706 |
Leishmania major | ATP-binding cassette protein subfamily G, member 1, putative | 0.0036 | 0.0834 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0706 | 0.0847 |
Trypanosoma brucei | ABC transporter, putative | 0.0036 | 0.0834 | 0.0275 |
Trypanosoma cruzi | ATP-binding cassette protein subfamily G | 0.0036 | 0.0834 | 0.0275 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0834 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0574 | 0.0689 |
Trypanosoma cruzi | ABC transporter, putative | 0.0033 | 0.0706 | 0.014 |
Brugia malayi | hypothetical protein | 0.0033 | 0.0706 | 0.0847 |
Giardia lamblia | ABC transporter | 0.0215 | 0.9872 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.6307 | 0.7568 |
Schistosoma mansoni | ABC transporter | 0.0184 | 0.8334 | 0.8334 |
Loa Loa (eye worm) | ABC transporter | 0.0184 | 0.8334 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.8206 | 0.8206 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1114 | 0.1114 |
Brugia malayi | hypothetical protein | 0.003 | 0.0574 | 0.0689 |
Trypanosoma cruzi | ATP-binding cassette protein subfamily G | 0.0036 | 0.0834 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2074 | 0.2489 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.6307 | 0.7568 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1114 | 0.1337 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1114 | 0.1337 |
Leishmania major | ATP-binding cassette protein subfamily G, member 2, putative | 0.0036 | 0.0834 | 0.0275 |
Toxoplasma gondii | ATP-binding cassette G family transporter ABCG96 | 0.0036 | 0.0834 | 0.0275 |
Mycobacterium leprae | Probable lipopolysaccharide transport integral membrane ABC transporter RfbD | 0.0033 | 0.0706 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily G, member 5, putative | 0.0036 | 0.0834 | 0.0275 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.6307 | 0.7568 |
Brugia malayi | RE11181p | 0.0033 | 0.0706 | 0.0847 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0706 | 0.0847 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2074 | 0.2489 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0834 | 0.0275 |
Toxoplasma gondii | ATP-binding cassette G family transporter ABCG107 | 0.0036 | 0.0834 | 0.0275 |
Trypanosoma cruzi | ABC transporter, putative | 0.0033 | 0.0706 | 0.014 |
Toxoplasma gondii | ATP-binding cassette G family transporter ABCG89 | 0.0036 | 0.0834 | 0.0275 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2074 | 0.2489 |
Trypanosoma cruzi | ABC transporter, putative | 0.0036 | 0.0834 | 0.0275 |
Brugia malayi | hypothetical protein | 0.002 | 0.003 | 0.0036 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.