TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 334.415 | Formula: C20H22N4O
H donors: 2 H acceptors: 4 LogP: 3.47 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OC1CCC(CC1)Nc1ncc2c(n1)c(ccc2)c1ccc(nc1)C
InChi: 1S/C20H22N4O/c1-13-5-6-14(11-21-13)18-4-2-3-15-12-22-20(24-19(15)18)23-16-7-9-17(25)10-8-16/h2-6,11-12,16-17,25H,7-10H2,1H3,(H,22,23,24)
InChiKey: GGSIOFMZSJTMMB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	jun proto-oncogene	Starlite/ChEMBL	References
Homo sapiens	mitogen-activated protein kinase 10	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	IPR000164,Histone H3;IPR009072,Histone-fold,domain-containing	Get druggable targets OG5_129677	All targets in OG5_129677
Echinococcus multilocularis	c Jun NH2 terminal kinase	Get druggable targets OG5_129677	All targets in OG5_129677
Echinococcus granulosus	c-Jun N-terminal kinases	Get druggable targets OG5_129677	All targets in OG5_129677
Echinococcus multilocularis	jun protein	Get druggable targets OG5_131442	All targets in OG5_131442
Brugia malayi	Stress-activated protein kinase jnk-1	Get druggable targets OG5_129677	All targets in OG5_129677
Echinococcus granulosus	jun protein	Get druggable targets OG5_131442	All targets in OG5_131442
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	Get druggable targets OG5_131442	All targets in OG5_131442
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	Get druggable targets OG5_131442	All targets in OG5_131442
Schistosoma japonicum	ko:K04440 c-Jun N-terminal kinase, putative	Get druggable targets OG5_129677	All targets in OG5_129677
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131442	All targets in OG5_131442
Brugia malayi	bZIP transcription factor family protein	Get druggable targets OG5_131442	All targets in OG5_131442
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	Get druggable targets OG5_129677	All targets in OG5_129677
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129677	All targets in OG5_129677

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	bZIP transcription factor family protein	0.0101	0.2535	0.2535
Echinococcus granulosus	biogenic amine 5HT receptor	0.0071	0.1247	0.1247
Brugia malayi	hypothetical protein	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Brugia malayi	MH2 domain containing protein	0.0137	0.4043	0.4043
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0101	0.2535	0.2535
Echinococcus multilocularis	dro:myosuppressin receptor	0.0071	0.1247	0.1247
Schistosoma mansoni	amine GPCR	0.0071	0.1247	0.1247
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0099	0.2418	0.1871
Schistosoma mansoni	amine GPCR	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Schistosoma mansoni	adenoreceptor	0.0071	0.1247	0.1247
Schistosoma mansoni	opsin-like receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	somatostatin receptor	0.0071	0.1247	0.1247
Brugia malayi	hypothetical protein	0.0071	0.1247	0.1247
Schistosoma mansoni	neuropeptide receptor	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0071	0.1247	0.1247
Echinococcus granulosus	neuropeptide receptor A26	0.0071	0.1247	0.1247
Echinococcus multilocularis	jun protein	0.0101	0.2535	0.2535
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Loa Loa (eye worm)	neuropeptide F receptor	0.0071	0.1247	0.0616
Schistosoma mansoni	neuropeptide receptor	0.0071	0.1247	0.1247
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0071	0.1247	0.1247
Echinococcus multilocularis	neuropeptide receptor A26	0.0071	0.1247	0.1247
Loa Loa (eye worm)	neuropeptide F receptor	0.0071	0.1247	0.0616
Brugia malayi	ORL1-like opioid receptor	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Brugia malayi	G protein-coupled receptor	0.0071	0.1247	0.1247
Echinococcus granulosus	neuropeptide Y receptor	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Echinococcus multilocularis	neuropeptide Y receptor	0.0071	0.1247	0.1247
Loa Loa (eye worm)	G-protein coupled receptor	0.0071	0.1247	0.0616
Loa Loa (eye worm)	MH2 domain-containing protein	0.0137	0.4043	0.3614
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Echinococcus multilocularis	orexin receptor type 2	0.0071	0.1247	0.1247
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.1247	0.1247
Schistosoma mansoni	neuropeptide F-like receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.1247	0.1247
Echinococcus granulosus	g protein coupled receptor	0.0071	0.1247	0.1247
Schistosoma mansoni	jun-related protein	0.0082	0.1733	0.1733
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0071	0.1247	0.1247
Echinococcus granulosus	sex peptide receptor	0.0071	0.1247	0.1247
Schistosoma mansoni	amine GPCR	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Schistosoma mansoni	amine GPCR	0.0071	0.1247	0.1247
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0071	0.1247	0.1247
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Brugia malayi	RE15519p	0.0071	0.1247	0.1247
Brugia malayi	putative neuropeptide receptor	0.0071	0.1247	0.1247
Echinococcus granulosus	tm gpcr rhodopsin	0.0071	0.1247	0.1247
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0071	0.1247	0.1247
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0071	0.1247	0.1247
Echinococcus granulosus	g protein coupled receptor	0.0071	0.1247	0.1247
Echinococcus granulosus	neuropeptide s receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.1247	0.1247
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0071	0.1247	0.1247
Echinococcus granulosus	7TM GPCR rhodopsin	0.0071	0.1247	0.1247
Echinococcus granulosus	orexin receptor type 2	0.0071	0.1247	0.1247
Brugia malayi	hypothetical protein	0.0071	0.1247	0.1247
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0071	0.1247	0.1247
Echinococcus multilocularis	serotonin receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	neuropeptide Y receptor	0.0071	0.1247	0.1247
Brugia malayi	G-protein coupled receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0101	0.2535	0.2535
Echinococcus granulosus	neuropeptides capa receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	allatostatin A receptor	0.0071	0.1247	0.1247
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.1247	0.1247
Brugia malayi	hypothetical protein	0.0071	0.1247	0.1247
Brugia malayi	putative neuropeptide receptor NPR1	0.0071	0.1247	0.1247
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0071	0.1247	0.1247
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Echinococcus multilocularis	fmrfamide receptor	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Echinococcus granulosus	dro:myosuppressin receptor	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0071	0.1247	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Schistosoma mansoni	biogenic amine receptor	0.0071	0.1247	0.1247
Schistosoma mansoni	hypothetical protein	0.0071	0.1247	0.1247
Echinococcus granulosus	g-protein coupled receptor	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0071	0.1247	0.1247
Brugia malayi	G-protein coupled receptor	0.0071	0.1247	0.1247
Echinococcus granulosus	hypothetical protein	0.0071	0.1247	0.1247
Loa Loa (eye worm)	TYRA-2 protein	0.0071	0.1247	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Loa Loa (eye worm)	transcription factor SMAD2	0.0137	0.4043	0.3614
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Brugia malayi	AKH receptor	0.0071	0.1247	0.1247
Echinococcus granulosus	tm gpcr rhodopsin	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0071	0.1247	0.1247
Echinococcus granulosus	neuropeptides capa receptor	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.1247	0.1247
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0071	0.1247	0.1247
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.1247	0.1247
Echinococcus multilocularis	neuropeptide receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Brugia malayi	Dopamine receptor protein 1	0.0071	0.1247	0.1247
Echinococcus multilocularis	neuropeptides capa receptor	0.0071	0.1247	0.1247
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.1247	0.1247
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.1247	0.1247
Brugia malayi	sulfakinin receptor protein	0.0071	0.1247	0.1247
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0071	0.1247	0.1247
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0071	0.1247	0.1247
Brugia malayi	hypothetical protein	0.0071	0.1247	0.1247
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0071	0.1247	0.1247
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0071	0.1247	0.1247
Schistosoma mansoni	opsin-like receptor	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.1247	0.1247
Schistosoma mansoni	amine GPCR	0.0071	0.1247	0.1247
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.1247	0.1247
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.0673	0.0673
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0071	0.1247	0.1247
Echinococcus granulosus	g protein coupled receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0071	0.1247	0.1247
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0071	0.1247	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	g protein coupled receptor	0.0071	0.1247	0.1247
Brugia malayi	follicle stimulating hormone receptor	0.0071	0.1247	0.1247
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.1247	0.1247
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0071	0.1247	0.1247
Echinococcus granulosus	tm gpcr rhodopsin	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Echinococcus granulosus	fmrfamide receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Brugia malayi	hypothetical protein	0.0071	0.1247	0.1247
Brugia malayi	G protein-coupled receptor F59B2.13	0.0071	0.1247	0.1247
Schistosoma mansoni	biogenic amine receptor	0.0071	0.1247	0.1247
Brugia malayi	Serotonin receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	serotonin receptor	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0071	0.1247	0.1247
Brugia malayi	hypothetical protein	0.0071	0.1247	0.1247
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.0673	0.0673
Echinococcus multilocularis	neuropeptide s receptor	0.0071	0.1247	0.1247
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.1247	0.1247
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.1247	0.1247
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0071	0.1247	0.1247
Brugia malayi	Melatonin receptor type 1A	0.0071	0.1247	0.1247
Schistosoma mansoni	myosin xvIII	0.0071	0.1247	0.1247
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0071	0.1247	0.1247
Brugia malayi	neuropeptide F receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	g protein coupled receptor	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Echinococcus granulosus	jun protein	0.0101	0.2535	0.2535
Echinococcus granulosus	neuropeptide Y receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	fmrfamide receptor	0.0071	0.1247	0.1247
Echinococcus granulosus	7tm_1 domain containing protein	0.0071	0.1247	0.1247
Schistosoma mansoni	neuropeptide receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	g protein coupled receptor	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Schistosoma mansoni	neuropeptide F-like receptor	0.0071	0.1247	0.1247
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.1247	0.1247
Brugia malayi	Dopamine receptor protein 2	0.0071	0.1247	0.1247
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0071	0.1247	0.0616
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0071	0.1247	0.1247
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0071	0.1247	0.0616
Brugia malayi	Serotonin receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0071	0.1247	0.1247
Schistosoma mansoni	hypothetical protein	0.0071	0.1247	0.1247
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0071	0.1247	0.1247
Schistosoma mansoni	neuropeptide f receptor 76f	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Schistosoma mansoni	opsin-like receptor	0.0071	0.1247	0.1247
Schistosoma mansoni	hypothetical protein	0.0071	0.1247	0.1247
Echinococcus granulosus	neuropeptide FF receptor 2	0.0071	0.1247	0.1247
Echinococcus granulosus	neuropeptide receptor	0.0071	0.1247	0.1247
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.1247	0.1247
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Echinococcus multilocularis	neuropeptides capa receptor	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Brugia malayi	Dopamine receptor	0.0071	0.1247	0.1247
Onchocerca volvulus		0.008	0.1616	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0071	0.1247	0.1247
Brugia malayi	hypothetical protein	0.0071	0.1247	0.1247
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.1247	0.1247
Echinococcus granulosus	G protein coupled receptor 139	0.0071	0.1247	0.1247
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0071	0.1247	0.1247
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.1247	0.1247
Brugia malayi	hypothetical protein	0.0071	0.1247	0.1247
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0071	0.1247	0.1247
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0071	0.1247	0.1247
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Schistosoma mansoni	growth hormone secretagogue receptor	0.0071	0.1247	0.1247
Schistosoma mansoni	hypothetical protein	0.0082	0.1733	0.1733
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Loa Loa (eye worm)	G-protein coupled receptor	0.0071	0.1247	0.0616
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0071	0.1247	0.1247
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	G protein coupled receptor 139	0.0071	0.1247	0.1247
Brugia malayi	hypothetical protein	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Schistosoma mansoni	biogenic amine receptor	0.0071	0.1247	0.1247
Echinococcus granulosus	biogenic amine 5HT receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	neuropeptide receptor	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Echinococcus granulosus	neuropeptide receptor	0.0071	0.1247	0.1247
Echinococcus granulosus	somatostatin receptor	0.0071	0.1247	0.1247
Schistosoma mansoni	neuropeptide receptor	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Brugia malayi	neuropeptide F receptor	0.0071	0.1247	0.1247
Schistosoma mansoni	histamine h1 receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0071	0.1247	0.1247
Schistosoma mansoni	hypothetical protein	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.1247	0.1247
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0071	0.1247	0.1247
Brugia malayi	larval opioid receptor	0.0071	0.1247	0.1247
Echinococcus granulosus	serotonin receptor	0.0071	0.1247	0.1247
Echinococcus granulosus	allatostatin A receptor	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0071	0.1247	0.1247
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1247	0.0616
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0071	0.1247	0.0616
Echinococcus multilocularis	g-protein coupled receptor	0.0071	0.1247	0.1247
Brugia malayi	hypothetical protein	0.008	0.1616	0.1616
Echinococcus multilocularis	sex peptide receptor	0.0071	0.1247	0.1247
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0071	0.1247	0.1247
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.1247	0.1247
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.1247	0.1247
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0071	0.1247	0.1247
Brugia malayi	GnHR receptor homolog	0.0071	0.1247	0.1247
Loa Loa (eye worm)	melatonin receptor type 1A	0.0071	0.1247	0.0616

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.05 uM	Inhibition of JNK3 by HRTF	ChEMBL.	21316221
IC50 (binding)	= 0.93 uM	Inhibition of c-Jun	ChEMBL.	21316221

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1761575

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1512707