Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0297 | 0.2439 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0297 | 0.2438 | 0.9998 |
Trypanosoma brucei | trans-sialidase, putative | 0.0297 | 0.2439 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.0297 | 0.2439 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0297 | 0.2439 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0297 | 0.2438 | 0.9998 |
Brugia malayi | MH2 domain containing protein | 0.0127 | 0.0902 | 0.0933 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0297 | 0.2438 | 0.9998 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0297 | 0.2439 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.0297 | 0.2439 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0127 | 0.0902 | 0.0933 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0297 | 0.2438 | 0.9998 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0297 | 0.2439 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0297 | 0.2439 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0297 | 0.2439 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0297 | 0.2439 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0297 | 0.2439 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0297 | 0.2439 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.1094 | 0.9664 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0703 | 0.6124 | 0.6124 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0297 | 0.2439 | 1 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.1094 | 0.9664 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0127 | 0.0902 | 0.0933 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.1094 | 0.9664 | 1 |
Trypanosoma brucei | trans-sialidase | 0.0297 | 0.2439 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0297 | 0.2439 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.0297 | 0.2439 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.1094 | 0.9664 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0297 | 0.2439 | 1 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.1094 | 0.9664 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.0297 | 0.2439 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0297 | 0.2439 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0297 | 0.2439 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 32.6427 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.