Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Thromboxane-A synthase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania donovani | cytochrome p450-like protein | Thromboxane-A synthase | 533 aa | 473 aa | 22.2 % |
Trypanosoma congolense | cytochrome P450, putative | Thromboxane-A synthase | 533 aa | 453 aa | 20.3 % |
Trypanosoma brucei gambiense | cytochrome P450, putative | Thromboxane-A synthase | 533 aa | 450 aa | 20.9 % |
Trypanosoma cruzi | cytochrome P450, putative | Thromboxane-A synthase | 533 aa | 448 aa | 20.5 % |
Leishmania major | cytochrome p450-like protein | Thromboxane-A synthase | 533 aa | 468 aa | 22.0 % |
Trypanosoma cruzi | cytochrome P450, putative | Thromboxane-A synthase | 533 aa | 450 aa | 20.7 % |
Leishmania braziliensis | cytochrome p450-like protein | Thromboxane-A synthase | 533 aa | 477 aa | 20.3 % |
Dictyostelium discoideum | cytochrome P450 family protein | Thromboxane-A synthase | 533 aa | 456 aa | 22.4 % |
Leishmania mexicana | cytochrome p450-like protein | Thromboxane-A synthase | 533 aa | 469 aa | 22.0 % |
Leishmania infantum | cytochrome p450-like protein | Thromboxane-A synthase | 533 aa | 473 aa | 22.2 % |
Onchocerca volvulus | Thromboxane-A synthase | 533 aa | 507 aa | 21.7 % | |
Trypanosoma brucei | cytochrome P450, putative | Thromboxane-A synthase | 533 aa | 450 aa | 20.9 % |
Dictyostelium discoideum | cytochrome P450 family protein | Thromboxane-A synthase | 533 aa | 544 aa | 19.9 % |
Loa Loa (eye worm) | cytochrome P450 family protein | Thromboxane-A synthase | 533 aa | 480 aa | 20.8 % |
Candida albicans | cytochrome P450 56 | Thromboxane-A synthase | 533 aa | 507 aa | 22.9 % |
Dictyostelium discoideum | cytochrome P450 family protein | Thromboxane-A synthase | 533 aa | 530 aa | 22.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0478 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0478 | 1 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0478 | 1 | 1 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0478 | 1 | 1 |
Onchocerca volvulus | 0.0478 | 1 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0478 | 1 | 1 |
Onchocerca volvulus | 0.0478 | 1 | 1 | |
Onchocerca volvulus | 0.0478 | 1 | 1 | |
Onchocerca volvulus | 0.0478 | 1 | 1 | |
Onchocerca volvulus | 0.0478 | 1 | 1 | |
Onchocerca volvulus | 0.0478 | 1 | 1 | |
Onchocerca volvulus | 0.0478 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Tested for antihypertensive activity in spontaneously hypertensive rats at 100 mg/kg peroral dosage for 2 days; I is inactive | ChEMBL. | 3681898 | |
IC50 (binding) | = 0.0000009 M | Tested for inhibition of thromboxane synthetase from spontaneously hypertensive rats | ChEMBL. | 3681898 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.